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All Journal Jurnal Profesi Medika: Jurnal Kedokteran dan Kesehatan Indian Journal of Forensic Medicine & Toxicology International Islamic Medical Journal AGRI-TEK : Jurnal Penelitian Ilmu-ilmu Eksakta Hang Tuah Medical Journal Medical and Health Journal
Diah Purwaningsari
Faculty Of Medicine, Universitas Hang Tuah, Surabaya, Indonesia
Religion Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Medicine & Pharmacology Nursing Public Health

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The Effect of Hypertension as a Comorbid Factor on the Length of Stay in Patients Undergoing Cholecystectomy Albertus Magnus Arya Abisatya; Diah Purwaningsari; Wahyu Prasasti Mutiadesi; Redemptus Yudadi
Indian Journal of Forensic Medicine & Toxicology Vol. 16 No. 2 (2022): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v16i2.17915

Abstract

Background: One of the gold standard procedures for cholelithiasis is cholecystectomy. Cholecystectomyhas numerous variated Length of stay results relies upon every nation and medical clinic. Hypertensionis perhaps the most widely recognized comorbid factors and are thought to impact prolonged length ofstay.Aim of Research: To study the effect of hypertension as a comorbid factor on the length of stay in patientsundergoing cholecystectomy in Dr. Ramelan Naval Hospital Surabaya from June 2019-September 2020.Method of Research: This is an analytic descriptive research with retrospective study. The samplingtechnique used in this research is total sampling. The data were collected from medical record data ofpatients at the Internal Medicine and Digestive Surgery Polyclinic.Result of Research: The number of patients who underwent cholecystectomy with hypertensionwho underwent a length of stay > 5 days were 36 people (83.7%). The result from the CoefficientContingency test shows that there is a correlation between hypertension as a comorbid factor and thelength of stay (p<0,0001).Conclusion: This research shows that there is comorbidity such as hypertension affects the length ofstay in cholecystectomy.
Wild Strawberry Fragaria vesca L. extracts Hepatoprotective Activities Against Paracetamol-Induced Hepatotoxicity in Male Wistar Rats Sihning E. J. T; Diah Purwaningsari; Nita Pranitasari; Liliawanti
Indian Journal of Forensic Medicine & Toxicology Vol. 16 No. 2 (2022): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v16i2.17995

Abstract

Background: Administration of high-dose paracetamol had been indicated to induce several molecular and biochemical cascades of hepatotoxicity. The abundant amount of ROS formation following the uptake of the medication exceeds the physiologic antioxidant capacity of the body, leading to the occurrence of oxidative stress. Wild strawberries (Fragaria vesca L)extractsare thought to have hepatoprotective activities regarding the high activity of antioxidants contained.Method: Aspartate Transaminase (AST) activity was used as a marker of hepatotoxicity. In the 10 days trial, randomized samples of 24 male Wistar rats (Rattus Norvegicus) were used and divided into three groups: 1 group without treatment, 1 group receiving oral paracetamol 1750 mg/kg in CMC-Na suspension, and 1 group receiving oral paracetamol 1750 mg/kg following administration of strawberry extract 400 mg/kg. The strawberry extract was administered from day 1 to 10, while high-dose paracetamol was administered on day 9. AST activity analysis was done on day 10 of the trial. Significant results were found showing an increased AST activity in the paracetamol-only group (p=0.001) and a decreased AST activity in the group receiving strawberry extract (p=0.001). Conclusion: Fragaria vesca L extracts were proven in vivo to have hepatoprotective activities against paracetamol-induced hepatotoxicity
The Antioxidant Effect of Noni Fruits Extract on HDL and LDL Level of Wistar Rat Induced by High Fat Diet Diah Purwaningsari; Sihning EJ Tehupuring; Nita Pranitasari; Suhailah Hayaza; Lestari Dewi; Dian Ardiana
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 2 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i2.14704

Abstract

Dyslipidemia is an important risk factor for myocardial infarction, cardiovascular diseases, and Nonalcoholic Fatty Liver (NAFLD) disorders. Inflammatory conditions, oxidative stress, and insulin resistance,as well as several risk factors for cardiovascular disease, are also risk factors for this disease. This study aimsto determine the effect of noni (Morinda citrifolia) extract on the improvement of dyslipidemia condition,based on the Low Density Lipoprotein (LDL) and High Density Lipoprotein (HDL) level. This research is alaboratory experimental study with a post-test only control group design. Male Wistar rat (Rattus norvegicus)were divided into four groups: negative control group with no induction and treatment (K-), positive controlgroup given high-fat diet induction for 14 days (K+), noni extract treatment group given a high-fat diet anda noni extract at a dose of 100 mg/kg BB per day for 7 days (P1), and noni extract at a dose of 200 mg/kgBB per day for seven days (P2). Low Density Lipoprotein and High Density Lipoprotein serum levels weremeasured using the ELISA method. The results showed that there was a significant increase in LDL and adecrease in HDL in both treatment groups (P1 and P2) compared with K(+) group. Therefore, we concludethat noni extract (Morinda citrifolia) played a role as an antioxidant which can increase LDL and decreaseHDL serum levels in rats induced by a high fat diet.
The Effect of Golden Sea Cucumber (StichopusHermanii) Extract on the Healing Process of the White Rat (Rattus Norvegicus) Indicated by Oral Ulcer– A Literature Review Dio Rafid Prakoso; Diah Purwaningsari; Sihning E.J.Tehupuring; Wachjudi Kurnia
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 3 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i3.15725

Abstract

Background Indonesia is a maritime country that is rich in marine resources. There are many marine resources that can be used as herbal medicine. One of them is the golden sea cucumber which is thought to be used as an alternative medicine to speed up the healing process of oral ulcers. The purpose of this study was to determine the effect of golden sea cucumber extract (Stichopushermanii) on the wound healing process in rats with oral ulcers.Method This research is a descriptive study with a literature review design. The articles used are articles published in international and national journals in the 2015-2020 period and are indexed by Scopus, Thomson Reuters, Web Science, Scimago and Sinta.Result The results of the scoping article show that there are active compounds in golden sea cucumbers, namely glycosaminoglycans that consist of hyaluronic acid, heparin / heparan sulfate (HP / HS), chondroitin sulfate / dermatan sulfate (CS / DS) and keratin sulfate (KS) which can form proinflammatory cytokines to trigger the emergence of immune defense cells and can bind to growth factors such as FGF2, VEGF, TGF-b, which will provide stimulation to accelerate the angiogenesis process, fibroblast ploriferation, endothelial differentiation, epithelial differentiation so as to accelerate the wound healing process.ConclutionThe conclusion of this study is the golden sea cucumber has the potency to accelerate the wound healing process by increasing fibroblast formation, collagen synthesis, endothelial differentiation and epithelial differentiation.
The Effect of Brown Seaweed (Sargassum sp.) Extract on Apoptosis Process in Breast Cancer – A Literature Review Ismylatifa Devi; Diah Purwaningsari; Nita Pranitasari; HerinSetianingsih
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 3 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i3.15803

Abstract

Breast cancer was one of the most common types of cancer in women and the major cause of death. Chemotherapy in breast cancer caused toxicity to the normal cells, resistance to the drugs, and several other side effects. Seaweed had many functional compounds that could be used as adjuvant therapy in breast cancer because of its anti-cancer properties called the proapoptotic agent. These compounds were fucoidan, phloroglucinol, and fucoxanthin. Their proapoptotic mechanisms shown by the journal were through increasing proapoptotic protein expression, decreasing antiapoptotic protein expression, inducing oxidative stress production on the cancer cell, and inhibiting the PI3K pathway. This review concludes that the brown seaweed (Sargassum sp.), which contains fucoidan, phloroglucinol, and fucoxanthin, could increase breast cancer cells’ apoptotic process.
THE EFFECT OF NONI (Morinda citrifolia) EXTRACT TO HEPAR HISTOPATHOLOGY AND TRIGLYCERIDE LEVEL IN RATS (Rattus Norvegicus) INDUCED BY DISLIPIDEMIA Jhouharotul Faradisah; Diah Purwaningsari
JURNAL AGRI-TEK : Jurnal Penelitian Ilmu-Ilmu Eksakta Vol. 20 No. 2 (2019): JURNAL AGRITEK
Publisher : Universitas Merdeka Madiun

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (672.695 KB) | DOI: 10.33319/agtek.v20i2.34

Abstract

Dyslipidemia is an abnormal lipid metabolism which may cause fat degeneration on hepatocytes cells and elevated triglyceride serum level. Dyslipidemia can be prevented by the consumption of high antioxidant food. Noni(Morinda citrifolia) contains many antioxidant such as flavanoid, kuersetin, tannin, and saponin, which are able to prohibit the elevation of ROS.This research is aimed to find out the effect of noni(Morinda citrifolia) extract in reducing the number of hepatocyte’s cells with fat degeneration and decreasing the triglyceride level which is elevated due to high cholesterol diet induction.In this study white rats divided randomly into 4 groups, control group (K-), high cholesterol diet induced group (K+), high cholesterol diet induced with 100 mg/Kg BW noni extract group (P1), high cholesterol diet induced with 200 mg/Kg BW noni extract group (P2). The result shows that noni  extract with dose 100 mg/Kg BW and  200 mg/Kg BWcan reduce the number of hepatocytes cells with fat degeneration (p= 0,026 and p=0,027) and decrease the level of triglyceride serum (p=0,036 and p=0,010).The conclusion is noni extract with dose 100 mg/KgBW reduces effectively  the number of hepatocyte’s cells with fat degeneration and decreases the level of triglyceride serum which increase because of high cholesterol diet. 
Pengaruh Ekstrak Daun Sirsak Terhadap Gambaran Histopatologi Pankreas Rattus Norvegicus Jantan yang Diinduksi Aloksan RIFKY YOGA PRATAMA; NITA PRANITASARI; DIAH PURWANINGSARI
HANG TUAH MEDICAL JOURNAL Vol 17 No 2 (2020): Hang Tuah Medical Journal
Publisher : Universitas Hang Tuah

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

ABSTRACT Background: Diabetes melitus is a metabolic disorder characterized by an increase in blood glucose levels caused by disruption of the pancreas in producing insulin. Alloxan is a substrate that can trigger the condition of hyperglycemia which can cause diabetes because of its toxic nature to pancreatic beta cells. The aim of this study to find out about the effect of soursop leaf (Annona muricata Linn) extract in repaired to pancreatic tissue damage of male wistar rats (Rattus norvegicus) induced by alloxan. Method : 24 male Wistar rats, divided into 3 groups : K(-) group that no treatment, K(+) group that induced by alloxan dose 150mg/kgBW and K(p) group that induced by alloxan dose 150mg/kgBW and given soursop leaf extract dose 150mg/kgBW. Result : there was significant difference (p = 0.001) of pancreatic tissue damage measured by histopathologic score between group of no treatment rats compared to the group of rats induced by alloxan. There was a significant difference of pancreatic tissue damage measured by histopatology score group of rats induced by alloxan compared to group of rats induced by alloxan and given soursop leaf extract. Conclusion : the administration of alloxan significantly increases the pancreatic tissue damage and the administration of soursop leaf extract can improve pancreatic tissue damage measured by histopathology score because soursop leaf extract contains flavonoids and tannins which function as antioxidants.
Hubungan Gambaran Foto Toraks dengan Derajat Keparahan Pasien COVID-19 di RSPAL dr. Ramelan MILLENIAWATI PUTRI NOVITANIA; RIKE ANDY WIJAYA; LILIAWANTI; DIAH PURWANINGSARI
HANG TUAH MEDICAL JOURNAL Vol 19 No 2 (2022): Hang Tuah Medical Journal
Publisher : Universitas Hang Tuah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30649/htmj.v19i2.187

Abstract

Background : The COVID-19 pandemic induced a challenge of the importance of diagnostic evaluation. This includes understanding signs and symptoms in diagnosing the probability of infection. The amount of clinical symptoms from the confirmed COVID-19 patient is the same as the other respiratory diseases, which makes it hard to diagnose at the beginning. The gold standard examination of COVID-19 is RT-PCR test and additional examination that usually done is radiology examination. The most used radiology examination is chest X-ray to identify any anomaly in patient's lungs and to evaluate the disease progress. The purpose of this research is to understand the existence of correlation between chest X-ray imaging and severity degree of COVID-19 patients that are treated in RSPAL dr. Ramelan Surabaya from November 2020-January 2021. Methods : The type of research is analytical observational study with case control design using 44 samples obtained from medical history of inpatients and outpatients that are confirmed positive of COVID-19 treated in RSPAL dr. Ramelan Surabaya in span of November 2020-January 2021. Bivariate analysis was performed using Spearman's test Results : From the result of bivariate analysis using Spearman's test appears significance score (p) = 0.0001 which <0.05 that shows the significant existence of connection between chest X-ray image and severity degree of COVID-19 patients. It is also found that the coefficient correlation score (r ) = 0.985 shows a positive correlation with strong correlation power. Conclusion : There is a connection between chest X-ray images and severity degree of COVID-19 patients. The more severe the clinical symptoms of a patient, the worse that patient's chest X-ray result will be. Keywords : COVID-19, Chest x-ray imaging, Severity degree.
Hubungan Status Gizi Pasien Penyakit Hirschsprung dengan Infeksi Luka Operasi di RSPAL dr. Ramelan Surabaya Periode Waktu 2016-2020 PUTU SITHA AISHWARYA SARASWATI GIUR Giur; SAPTA PRIHARTONO RACHMAN; DIAH PURWANINGSARI; PRAWESTY DIAH UTAMI
HANG TUAH MEDICAL JOURNAL Vol 20 No 1 (2022): Hang Tuah Medical Journal
Publisher : Universitas Hang Tuah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30649/htmj.v20i1.279

Abstract

Background: Hirschsprung's disease is a congenital intestinal motility disorder that causes functional intestinal obstruction due to the absence of enteric ganglion cells in the distal intestine. The management of each case of Hirschsprung's disease is surgery, where surgery on the digestive tract increases the occurrence of surgical site infections. Disturbances in the gut cause decreased resistance to infection, delayed cognitive development, and problems with nutritional status. Methods: This study was a descriptive and analytical observational study, where the primary data were taken from the registration data of Hirschprung's disease patients at RSPAL dr. Ramelan Surabaya in 2016-2020. The nutritional status of the patient was determined by plotting the weight per age curve according to WHO for children aged 0-5 years. Results: Observations of 38 patients who met the study requirements, obtained 4 patients who had poor nutritional status and 1 patient who had excess nutritional status, none of which experienced complications in the form of surgical wound infections. In 10 patients with poor nutritional status, 2 experienced complications in the form of surgical wound infection and 23 patients with good nutritional status, 1 experienced complications in the form of surgical wound infection. The results of the contingency coefficient correlation test showed P-value = 0.408 (p>α). Conclusion: There was no relationship between the nutritional status of Hirschprung's disease patients with surgical wound infections at RSPAL dr. Ramelan Surabaya Keywords: Hirschsprung's disease, nutritional status of children, surgical site infection.
Gambaran Sindrom Mata Kering pada Mahasiswa Fakultas Kedokteran Universitas Hang Tuah Angkatan 2018: Sindrom mata kering RASYAD, CHICO MUHAMMAD; SAMSUDIN, MOH; PURWANINGSARI, DIAH
Hang Tuah Medical Journal Vol 21 No 1 (2023): Hang Tuah Medical Journal
Publisher : Universitas Hang Tuah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30649/htmj.v21i1.161

Abstract

Dry eye syndrome (DES) is a multifactorial disease of the ocular surface caused by hyperosmolarity of tears. Dry eyes can interfere with activities because it causes pain dan discomfort in the eyes. Gender and duration of gadget use are part of the risk factor for dry eye syndrome. This study was conducted with the aim of knowing the description of dry eye syndrome in students of the Faculty of Medicine Hang Tuah University Class of 2018. This type of study is descriptive. This research was conducted at the Faculty of Medicine, Hang Tuah University. The study was conducted from April 2021-November 2021. Data were obtained from online questionnaires on 154 students of the Faculty of Medicine, Hang Tuah University, Class of 2018. The sample was selected using simple random sampling method. The result showed that the severity of dry eye syndrome was 20.1% in the normal category, 19.5% in the mild category 22.1% in the moderate category and 38.3% in the severe category. In the male gender, 32.6% were found normal, 20.9% in the mild category, 16.3% in the moderate category and 30.2% in the sever category. In female gender, 15.3% were found in the normal category, 19.0% in the mild category, 24.3% in the moderate DES and 41.4% in the severe DES. The light duration of gadget usage shows 66.7% mild and 33.3% in the severe DES. The medium duration of gadget usage shows 30.7% normal, 15.4% in the mild DES, 38.5% in the moderate DES, 15.4 in the severe DES. The severe duration of gadget usage shows 19.6% normal, 18.8% with mild DES, 21,0% with moderate DES and 40,6% with severe DES. The conclusion of this study is the severity of DES is high, the female gender has higher prevalence of severity compared to male gender and the severe duration of gadget usage has a higher prevalence of severity. Keyword: Dry eye syndrome, severity, gender, duration of gadget usage
Co-Authors Albertus Magnus Arya Abisatya Ardiana, Dian Dian Ardiana Dio Rafid Prakoso Eric Mayo Dagradi Ferguszon, Devina Hanalily Maharani Firda, Armadani Aisyah Indri Ngesti Rahayu Ismylatifa Devi Jhouharotul Faradisah Komalasari, Intan Lestari Dewi LILIAWANTI Liliawanti MILLENIAWATI PUTRI NOVITANIA NITA PRANITASARI Nita Pranitasari Poerwanto, Eka Prawesty Diah Utami PUTU SITHA AISHWARYA SARASWATI GIUR Giur RASYAD, CHICO MUHAMMAD Redemptus Yudadi RIFKY YOGA PRATAMA RIKE ANDY WIJAYA SAMSUDIN, MOH SAPTA PRIHARTONO RACHMAN Setianingsih, Herin Sihning E. J. T Sihning E.J.Tehupuring Sihning EJ Tehupuring Suhailah Hayaza Wachjudi Kurnia Wahyu Prasasti Mutiadesi Wienta Diarsvitri, Wienta Wijayanti, Ni Luh Putu Ratih