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All Journal Jurnal Biologi Tropis Mitra Mahajana: Jurnal Pengabdian Masyarakat
Hayon, Melkior Bala
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Computer Science & IT Decision Sciences, Operations Research & Management Education Immunology & microbiology Industrial & Manufacturing Engineering Public Health Social Sciences

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The Role of Mitochondria in Cellular Energy Production and Bioenergetic Regulation: A Qualitative Meta-Analysis Mala, Nurfadila; Mala, Benedikta Odaliva; Papa, Florentina Christiani; Hayon, Melkior Bala; Wae, Veronika P. Sinta Mbia
Jurnal Biologi Tropis Vol. 25 No. 4b (2025): Special Issue
Publisher : Biology Education Study Program, Faculty of Teacher Training and Education, University of Mataram, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v25i4b.10984

Abstract

Mitochondria play a central role in cellular energy production through oxidative phosphorylation that generates ATP, while also regulating metabolism, organelle dynamics, and bioenergetic signal integration. This study aims to synthesize the role of mitochondria in cellular bioenergetics through a qualitative meta-analysis of scientific articles published between 2015 and 2025. The PRISMA approach was applied for systematic article selection, resulting in 30 relevant articles analyzed for key findings. The synthesis shows that mitochondria do not operate in isolation but form a functional network that adjusts ATP production according to the specific energy demands of the cell. Mitochondrial fusion-fission dynamics influence energy distribution efficiency, while metabolic regulation and interactions with other organelles maintain cellular energy homeostasis. Mitochondrial dysfunction is associated with neuromuscular disorders, aging, and degenerative diseases including cancer. The study concludes that mitochondria are adaptive bioenergetic centers, playing a crucial role in maintaining energy efficiency and providing a scientific basis for further research in cellular biology, biomedicine, and energy-based therapeutic applications. This synthesis expands understanding of mitochondrial bioenergetic mechanisms and their implications for health and biotechnology applications.
EDUCATION ON ADDICTIVE AND ADDICTIVE SUBSTANCES AND EXPERIMENTS: THE DANGERS OF SMOKING TO HEALTH Mete, Yuliana Yenita; Gago, Jumilah; Ota, Maria Kristina; Nisa, Fadhila Chairul; Keke, Adolfin; Da Jeen, Maria Nggara Jaru; Hayon, Melkior Bala; Leraboleng, Novensianus; Gene, Agustina Tiara
Mitra Mahajana: Jurnal Pengabdian Masyarakat Vol. 6 No. 3 (2025): Volume 6 Nomor 3 November 2025
Publisher : LPPM Universitas Flores

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37478/mahajana.v6i3.7082

Abstract

Adolescent smokers are a group particularly vulnerable to the negative effects of addictive and addictive substances in cigarettes, such as nicotine and tar. Limited understanding of the risks of smoking increases the likelihood of becoming active smokers or being affected by passive smoking and third-hand smoke. The Student Creativity Program was conducted at SMP Adhyaksa Ende, aiming to enhance students’ knowledge about the dangers of smoking through a simple and interactive practical approach. The activities included an initial presentation, a practicum demonstration using a plastic bottle filled with water with holes on the top and bottom, where a small pipe was installed at the bottom hole. Cotton at the bottle mouth served as a filter, while a cigarette was placed in the top hole to demonstrate the release of harmful substances. During the session, students were actively engaged through question-and-answer discussions regarding the effects of nicotine, tar, and passive smoking risks, making the learning process interactive. The results showed increased student awareness of smoking risks, their ability to identify harmful substances in cigarette smoke, and visual understanding of smoke dispersion and filtration. The discussion emphasizes the importance of combining demonstrative, participatory, and interactive methods to strengthen adolescents’ understanding and develop critical attitudes toward smoking. In conclusion, this PKM effectively conveyed information on addictive and addictive substances, enhanced student engagement, and fostered preventive awareness. Recommended follow-up actions include repeating the program in other classes, integrating adolescent health education into the school curriculum, and developing interactive educational modules based on simple practicums to sustain awareness of smoking hazards.
Co-Authors Da Jeen, Maria Nggara Jaru Gago, Jumilah Gene, Agustina Tiara Keke, Adolfin Leraboleng, Novensianus Mala, Benedikta Odaliva Mala, Nurfadila Maria Kristina Ota Nisa, Fadhila Chairul Papa, Florentina Christiani Wae, Veronika P. S. M. Yuliana Yenita Mete