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All Journal JPNM : Jurnal Pustaka Nusantara Multidisiplin Jurnal Riset Multidisiplin Edukasi
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Efek Antiinflamasi Kombinasi Astaxanthin Dengan Vitamin E Terhadap Jumlah Neutrofil Studi Eksperimental pada Tikus Putih Jantan Galur Wistar yang Diinduksi Karagenan Herliana Junita; Sampurna
JPNM Jurnal Pustaka Nusantara Multidisiplin Vol. 4 No. 1 (2026): February : Jurnal Pustaka Nusantara Multidisiplin (ACCEPTED)
Publisher : SM Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59945/jpnm.v4i1.943

Abstract

Inflamasi dapat terjadi akibat induksi karagenan 1% melalui ikatan dengan Toll Like Receptor-4 (TLR-4) ditandai peningkatan jumlah neutrofil dalam darah. Astaxanthin termasuk karetenoid lipofilik bersifat antiinflamasi, selain itu vitamin E juga bersifat antiinflamasi. Tujuan dari penelitian ini untuk mengetahui efek antiinflamasi kombinasi astaxanthin dengan vitamin E tikus putih jantan galur wistar yang diinduksi karagenan. Penelitian eksperimen dengan desain Post test only control group design. Sebanyak 30 ekor tikus dibagi 3 kelompok secara acak (KN: kelompok normal, KS: kelompok sakit dengan induksi karagenan 1%, dan KP: kelompok perlakuan dengan kombinasi astaxanthin 0,72 mg/kgBB dengan vitamin E 24,1 mg/kgBB dan diinduksi karagenan 1%). Setelah perlakuan, jumlah neutrofil dihitung dengan Hematology analyzer dan dianalisis dengan uji normalitas, homogenitas, One Way ANOVA dilanjutkan uji Post Hoc LSD. Rerata jumlah neutrofil pada KN, KS, dan KP secara berurutan adalah 1,03; 3,31; dan 1,77 (x103/mm3). Hasil uji normalitas dan uji homogenitas (p>0,05), One Way ANOVA didapatkan p<0,05 jumlah neutrofil yang bermakna antara ketiga kelompok. Uji Post Hoc LSD didapatkan p<0,05 menyatakan adanya perbedaan signifikan jumlah neutrofil pada semua kelompok. Dari hasil penelitian dapat disimpulkan terdapat efek antiinflamasi kombinasi astaxanthin dengan vitamin E terhadap jumlah neutrofil pada tikus putih jantan galur wistar yang diinduksi karagenan.
EFEK ANTIINFLAMASI KOMBINASI ASTAXANTHIN DENGAN VITAMIN E TERHADAP JUMLAH TROMBOSIT (Studi Eksperimental pada Tikus Putih Jantan Galur Wistar yang Diinduksi Karagenan) Salsabila Tria Ramadhani; Sampurna
Jurnal Riset Multidisiplin Edukasi Vol. 2 No. 12 (2025): Jurnal Riset Multidisiplin Edukasi (Edisi Desember 2025)
Publisher : PT. Hasba Edukasi Mandiri

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.71282/jurmie.v2i12.1493

Abstract

Background: Inflammation is a defense reaction involving cells, mediators, and blood vessels, including platelets, to eliminate causes of cell damage. Carrageenan is a cause of cell damage that induces platelets through the NF-κB pathway by TLR-4 signaling. The combination of astaxanthin and vitamin E has anti-inflamatory effects characterized by a decrease in platelet count by suppressing NF-κB, COX-2, and ROS activity. Objective: This study aims to determine the effect of the combination of astaxanthin and vitamin E on platelet counts in male Wistar rats induced by carrageenan. Method: This study was experimental with a post-test only control group design. A total of 30 rats were adapted for 7 days with the same feed and drink, then the rats were divided into a normal group (n=10), a sick group (n=10), and a treatment group (n=10). The treatment group was given a combination of 0.72 mg/kgBW astaxanthin and 24.1 mg/kgBW vitamin E. One hour later, the sick and treatment groups were given a 0.1 mL injection of 1% carrageenan and waited for 24 hours, while the normal group was only given standard feed. The platelet count was measured using a hematology analyzer. The data were analyzed using the Shapiro Wilk test, Levene Statistic, Kruskal Wallis, and followed by the Mann Whitney Post Hoc test. Result: The mean platelet count was 144.86 × 10³/µL in the normal group, 316.79 × 10³/µL in the sick group, and 214.07 × 10³/µL in the treatment group. The results of the normality test KP (p<0.05), KN and KS (p>0.05), homogeneity (p<0.05), Kruskal Wallis (p<0.05) were significantly different, and the Post Hoc Mann Whintney (p<0.05) showed significant differences between all groups. Conclusion: Data analysis revealed an anti-inflammatory effect of the combination of astaxanthin and vitamin E in carrageenan-induced rats.
Co-Authors Herliana Junita Salsabila Tria Ramadhani