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All Journal Denta: Jurnal Kedokteran Gigi Journal of Dental and Biosciences
Helmi Hirawan
Unknown Affiliation
Dentistry Health Professions Medicine & Pharmacology Public Health

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The Effect of Addition of Nano hydroxyapatite Powder of Anadara granosa Shells on Surface Roughness of Heat-cured Acrylic Resin Aris Aji Kurniawan; Dian Noviyanti Agus Imam; Helmi Hirawan
Denta Journal Kedokteran Gigi Vol 14 No 2 (2020): Agustus
Publisher : Fakultas Kedokteran Gigi Universitas Hang Tuah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30649/denta.v14i2.5

Abstract

Background: Heat-cured acrylic resin is one of the most widely used denture base materials. However, the residual monomer can reduce its mechanical properties, which affect physical properties such as surface roughness, resulting in high porosity—the results in the growth of fungal colonies. One way to improve these properties is to add a reinforcement material such as nano-hydroxyapatite (HAp) from the Anadara granosa shell. Nano-hydroxyapatite has a large surface area to act as a filler because of its strong bonding capacity and a smoother surface, and a higher density to improve mechanical properties. Purpose: This study aims to determine HAp powder's effect from the Anadara granosa shells on the surface roughness of heat-cured acrylic resin. Methods: This type of research used an experimental laboratory, research design posttest-only control group design. Twenty-four samples were used and divided into three groups: the acrylic resin group with 1%, 3% blood cockles shell HAp, and acrylic resin without HAp with simple random sampling. Results: The results showed that the lowest mean value of surface roughness was in a group with the addition of 3% HAp, at 1.696 ± 0.25058 µm. One-Way ANOVA test on roughness showed a significant difference between groups with p = 0.000 (p <0.05). Conclusion: This study concludes that there is an effect of HAp on the roughness of heat-cured acrylic resin.
Effect of topical Apis trigona honey on FGF-2 expression, fibroblast, and capillary blood vessel counts in post-extraction wound healing Anita Dyah Septiani; Haris Budi Widodo; Helmi Hirawan; Ali Taqwim
Journal of Dental and Biosciences Vol 3 No 02 (2026): Journal of Dental and Biosciences
Publisher : Jurusan Kedokteran Gigi Fakultas Kedoketaran Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.jdentbios.2026.3.02.21671

Abstract

Background: Tooth extraction causes a wound in the tooth socket that may lead to complications and delayed healing. The acceleration of wound healing can be observed through fibroblast growth factor-2 (FGF-2) expression, the number of fibroblasts, and the number of capillary blood vessels. Trigona honey, produced by the stingless bee Apis trigona, contains flavonoids with antibacterial and antioxidant properties and is traditionally used to support healing. This study aimed to determine the effect of topical Apis trigona honey on FGF-2 expression, fibroblast count, and capillary blood vessel count in post-extraction wound healing. Methods: This laboratory experimental study used 32 male guinea pigs (Cavia porcellus) divided into a control group (n=16) and a treatment group (n=16). Following incisor extraction, the treatment group received 0.5 mL of topical Apis trigona honey, while the control group received sterile distilled water only. On day three, the animals were sacrificed and mandibular tissue was harvested. FGF-2 expression was assessed by immunohistochemistry, while fibroblast and capillary blood vessel counts were assessed with haematoxylin-eosin staining. Data were analysed using an independent t-test (95% confidence interval, p<0.05). Results: FGF-2 expression did not differ significantly between the control and treatment groups (p=0.078). However, the treatment group showed significantly higher fibroblast counts (p<0.001) and capillary blood vessel counts (p<0.001) compared with the control group. Conclusion: Topical application of Apis trigona honey did not increase FGF-2 expression but significantly increased fibroblast and capillary blood vessel counts, suggesting its potential as a supportive agent in post-extraction wound healing.
Co-Authors Ali Taqwim Anita Dyah Septiani Aris Aji Kurniawan Dian Noviyanti Agus Imam Haris Budi Widodo