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All Journal Jurnal Insan Farmasi Indonesia Jurnal Pharma Bhakta
Wahyudin Bin Jamaludin
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Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Immunology & microbiology Medicine & Pharmacology Physics

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FORMULASI DAN EVALUASI SEDIAAN CLAY MASK ESKTRAK ETANOL 96% DAUN SIRIH CINA (Peperomia pellucida L.) DENGAN VARIASI KAOLIN DAN BENTONITE. M. Andi Chandra; Wahyudin Bin Jamaludin; Ariska Nurjannah Aman, A.N.
Jurnal Insan Farmasi Indonesia Vol 8 No 2 (2025): Jurnal Insan Farmasi Indonesia
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/pqvc9988

Abstract

Peperomia pellucida L extract exhibits antibacterial activity and may be developed into a cosmetic clay mask. Variations in kaolin and bentonite concentrations can affect the physical properties and stability of the formulation. This study aimed to evaluate the characteristics of clay mask formulations containing ethanol extract from Chinese betel leaf and to identify the most optimal formulation based on stability testing via the cycling test method. An experimental method was used with six variations of kaolin and bentonite: F1 (30% kaolin; 20% bentonite), F2 (32.5%; 17.5%), F3 (35%; 15%), F4 (37.5%; 12.5%), F5 (0%; 25%), and F6 (40%; 0%). Evaluations included organoleptic properties, homogeneity, pH (4.76–5.12), spreadability (4.05–4.37 cm), moisture content (33.3–38.01%), drying time (16–30 minutes), and viscosity (3,600–16,833 mPa·s). The results showed that all formulations exhibited good physical characteristics. Formulation F4 (37.5% kaolin and 12.5% bentonite) was the optimal formulation based on its superior stability, appropriate drying time, viscosity within the ideal range, and skin- compatible pH.
FORMULASI DAN UJI AKTIVITAS GEL ANTI ACNE BERBASIS EKSTRAK DAUN RAMANIA (Bouea macrophylla Griffith) TERHADAP BAKTERI Cutibacterium acnes Muhammad Fadhil Kamil; Fitriyanti Fitriyanti; Wahyudin Bin Jamaludin
JURNAL PHARMA BHAKTA Vol 6 No 1 (2026): Mei (2026)
Publisher : FACULTY OF PHARMACY, INSTITUT ILMU KESEHATAN BHAKTI WIYATA

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Abstract

Background: Acne is an inflammatory condition of the pilosebaceous unit involving infection by Cutibacterium acnes. Ramania leaves (Bouea macrophylla) contain flavonoids, saponins, and tannins with known antibacterial properties. Objective: This study aimed to formulate a methanolic extract gel of Ramania leaves and evaluate its physical and organoleptic qualities as well as its antibacterial activity against C. acnes. Method: The extract was obtained via maceration and formulated in a carbopol-based gel with concentrations of 5%, 7.5%, 10%, 15%, and 20%. Physical evaluations included organoleptic testing, homogeneity, pH, viscosity, adhesiveness, and spreadability. Antibacterial activity was tested using the well diffusion method. Results: showed all gel formulas met standard physical and organoleptic criteria. The 5% extract gel demonstrated the largest inhibition zone against C. acnes (22.8 mm ± 2.06). Concentrations above 10% showed decreased effectiveness, likely due to saturation or physical instability. Conclusion: The 5% Ramania leaf extract gel is the most effective and stable formulation for topical anti-acne application
Co-Authors Ariska Nurjannah Aman, A.N. Fitriyanti Fitriyanti M. Andi Chandra Muhammad Fadhil Kamil