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All Journal International Journal of Health and Pharmaceutical (IJHP) Journal Of Pharmacy
Mokhamad mahroji
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Biochemistry, Genetics & Molecular Biology Medicine & Pharmacology Nursing Public Health

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Antioxidant Activity Test Combination Of Cantigi Leaf Extract (Vaccinium varingiaefolium) And Nail Henna Leaf Extract (Lawsonia inermis Linn) Mokhamad mahroji; Shelly Taurhesia; Dian Ratih Laksmitawati
International Journal of Health and Pharmaceutical (IJHP) Vol. 2 No. 1 (2022): February 2022
Publisher : CV. Inara

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (150.456 KB) | DOI: 10.51601/ijhp.v2i1.32

Abstract

Traditionally, cantigi leaves ( Vaccinium varingiaefolium ) are used to heal wounds,swelling, burning, pain, ulcers, and function as analgesic, anti-inflammatory and antiinflammatory. inflammation, and treat fine wrinkles . henna leaves ( Lawsonia inermisLinn ) which contains glycosides, steroids, phytosterols, saponins, tannins, andflavonoids which are reported to have benefits for treating boils, scabies, headaches,back pain, and can accelerate hair growth . Cantigi leaves and fruit are reported tocontain anthocyanin compounds that function as antioxidants . while the antioxidantscontained in cantigi leaves are Beta.-mono-olein , Hexadecanoic acid, and methyl ester. The flavonoids contained in henna leaves also have the potential as antioxidants. Weare often exposed to oxidation both produced from within the body or from outside suchas pollution, cigarette smoke, UV radiation and food. Antioxidants will neutralize thesefree radicals so they do not have the ability to steal electrons from cells and DNA.Cantigi leaves and henna leaves were macerated by kinetic maceration method with70% ethanol as solvent. Antioxidants were measured using the DPPH method, thesingle extract of cantigi gave an IC 50 value of 119.23 ± 4.41 µg/mL , while the extractof a single nail henna gave an IC 50 value of 38.38 ± µg/mL. The combination ofcantigi leaf extract and nail henna leaf extract with a ratio of 1:1; 2:1 and 1:2 gavevery strong IC50 values, namely 33.84 µg/mL; 40.40 µg/mL and 29.85 µg/mL,respectively. It was concluded that the combination of cantigi leaf extract and nailhenna leaf extract with a ratio of 1:2 gave the best IC50 value of 29.85 µg/mL.
Prediksi Profil Farmakokinetik dan Toksisitas Senyawa Aktif Ekstrak Daun Kratom (Mitragyna speciosa) Secara In Silico Menggunakan pkCSM dan SwissADME anjas, Anjas Wilapangga; Nia marlina Kurnia; Mokhamad Mahroji; Arif Hidayat
The Journal Of Pharmacy Vol. 2 No. 2 (2025): Journal Of Pharmacy UMRI
Publisher : LPPM, Universitas Muhammadiyah Riau

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Abstract

The kratom plant (Mitragyna speciosa) has several beneficial pharmacological effects in humans. The pharmacokinetic profiles of secondary metabolites from kratom leaf extract were examined. The aim of this study was to predict the pharmacokinetic and toxicity profiles of active compounds from kratom leaf extract (Mitragyna speciosa) in silico using pkCSM and SwissADME tools. The five main compounds studied were mitragynine, 7-hydroxymitragynine, paynantheine, speciogynine, and speciociliatine. Pharmacokinetic predictions showed that all compounds had good oral absorption profiles and high blood-brain barrier (BBB) ​​penetration, consistent with their pharmacological effects on the central nervous system. However, mitragynine and 7-hydroxymitragynine were predicted to have strong interactions with cytochrome P450 enzymes, particularly CYP3A4 and CYP2D6, indicating potential serious drug-drug interactions. In terms of toxicity, mitragynine is predicted to have mild hepatotoxicity and low genotoxicity. Meanwhile, 7-hydroxymitragynine exhibits a higher toxicity risk profile due to its potent opioid interactions. Overall, these in silico data provide important insights into the potential risks and benefits of kratom use. These results provide a strong foundation for further experimental and clinical studies to validate these predictions and develop guidelines for safe and responsible use.
Co-Authors Anjas, Anjas Wilapangga ARIF HIDAYAT Dian Ratih Laksmitawati Kurnia, Nia Marlina Shelly Taurhesia