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All Journal Journal of Information Systems and Informatics
Afif, Justivan Intifadhah
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Computer Science & IT

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Empirical Evaluation of Decentralized Genomic Data Computation Using Bacalhau and IPFS Triaji, Bagas; Badiyanto, Badiyanto; Afif, Justivan Intifadhah
Journal of Information System and Informatics Vol 7 No 4 (2025): December
Publisher : Asosiasi Doktor Sistem Informasi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.63158/journalisi.v7i4.1311

Abstract

Large-scale genomic analysis typically relies on centralized infrastructures, creating conflicts between collaborative needs and data sovereignty regulations. This study solves this dilemma by evaluating a decentralized architecture designed to facilitate secure, inter-institutional genomic computation without moving raw data. We integrated Bacalhau for orchestration and IPFS Cluster with CRDT consensus for storage, employing AES-256 encryption. A quantitative evaluation was conducted on AWS using five t3.medium nodes to simulate a resource-constrained hospital network. We tested three scenarios: a centralized baseline (SSH+SCP), an ideal decentralized workflow, and a "chaos" scenario involving active network fault injection. While the centralized baseline was the fastest (Mean=37.69s), the decentralized architecture incurred a manageable ~30% overhead under ideal conditions (Mean=49.22s, SD=1.58s). Critically, under chaos fault injection, although execution time increased to 90.67s (SD=17.84s), the system achieved a superior 100% job completion rate compared to the fragile baseline. This research quantifies the trade-off between execution speed and system resilience in a healthcare context. We demonstrate that this architecture prioritizes data sovereignty and high availability over raw speed, offering a proven model for privacy-critical Decentralized Science (DeSci) collaborations.
Co-Authors Badiyanto, Badiyanto Bagas Triaji