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All Journal Pediatric Sciences Journal
Putra, Galing C.
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Health Professions Public Health

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Comparison of tolerance of peptide-based formula versus standard formula on outcome of critically ill children: an evidence-based case report Permadi, Prasetya I.; Melinda; Yuliarto, Saptadi; Kadafi, Kurniawan Taufiq; Koentartiwi, Dyahris; Putra, Galing C.
Pediatric Sciences Journal Vol. 6 No. 2 (2025): In Press Online : December 2025
Publisher : Medical Faculty of Brawijaya University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51559/pedscij.v6i2.122

Abstract

Introduction. The clinical benefit of peptide-based formulas remains controversial in critically ill children. Objective. To conduct a critical review to compare the effects of peptide-based versus standard polymeric formulas on feeding tolerance and whether this would affect outcomes in critically ill children. Methods. An online search was conducted using PubMed, Cochrane, and the New England Journal of Medicine (NEJM) databases using the keywords “Peptide-based Formula,” “Standard Formula,” “Critically ill Children,” and “Enteral Feeding.” Results. Three articles were found: a case-control study and two prospective cohort studies. The results of the case-control study suggested that critically ill patients receiving peptide-based formulas showed significant reductions in feeding disturbances and abdominal distension and achieved full enteral feedings sooner compared with patients receiving standard formulas. The results of the first prospective cohort study showed that the peptide-based formula was better tolerated than the standard formula in children after bowel surgery, and the second study stated that choosing the peptide-based formula as the first prescription for enteral nutrition was associated with higher severity of clinical conditions in patients. Conclusion. The peptide-based formula was better tolerated than the standard polymeric formula in critically ill pediatric patients.
Co-Authors Koentartiwi, Dyahris Kurniawan Taufiq Kadafi Melinda Permadi, Prasetya I. Saptadi Yuliarto