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All Journal Jurnal Farmasi Teknologi Sediaan dan Kosmetika (JFTSK) Jurnal Widya Medika
Upara, Nana Nurindah
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Health Professions Industrial & Manufacturing Engineering Medicine & Pharmacology

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MANAGEMENT OF UROSEPSIS COINCIDENT WITH HYPERTHYROIDISM: A CASE REPORT Papeo, Dizky Ramadani Putri; Marhaba, Zulkarnain; Upara, Nana Nurindah; Yusuf, Siti Rahmatia; Az-zahra, Vivilia; Delia, Faizha Putri; Kuengo, Gerrald Hariyawan
JURNAL WIDYA MEDIKA Vol. 12 No. 1 (2026): March
Publisher : FAKULTAS KEDOKTERAN UNIVERSITAS KATOLIK WIDYA MANDALA SURABAYA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33508/jwm.v12i1.7852

Abstract

Urosepsis is a life-threatening infection originating from the urinary tract and can trigger systemic inflammation. The presence of hyperthyroidism can worsen the prognosis due to increased metabolic rate and hemodynamic instability. This case reports a 54-year-old man who presented to the emergency department with generalized weakness since the previous day, accompanied by nausea without vomiting and intermittent fever that appeared one month after being discharged from the hospital. The patient was subsequently diagnosed with urosepsis with comorbid hyperthyroidism, indicating that the urinary tract infection had progressed to sepsis, further complicated by the pre-existing thyroid condition. Combination therapy with meropenem, levofloxacin, propylthiouracil, and propranolol with supportive therapy showed improvement in clinical condition and laboratory parameters, including a decrease in the leukocyte count and normalization of body temperature. Multidisciplinary management involving infection control and thyroid regulation was effective in stabilizing the patient's condition. This case report aims to describe the management of urosepsis in a patient with comorbid hyperthyroidism using the SOAP approach as a clinical summary.
Characterization of Tannic Acid Chemically Crosslinked PVA Chitosan Hydrogel Upara, Nana Nurindah; Taupik, Muhammad; Latif, Multiani S; Rasdianah, Nur; Suryadi, A. Mut’hi Andy
Jurnal Farmasi Teknologi Sediaan dan Kosmetika Vol. 3 No. 1 (2026): Volume 3 Nomor 1 Tahun 2026
Publisher : Jurnal Literasi Mandiri

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70075/jftsk.v3i1.287

Abstract

Hydrogel is a hydrophilic material that can absorb and retain large amounts of water through the formation of hydrogen bonds between polymer functional groups to form a stable three-dimensional network. The physicochemical characteristics of hydrogels are greatly influenced by the cross-linking process that determines the network density and stability of the preparation. This study aims to determine the effect of variations in the concentration of tannic acid as a chemical crosslinker on the physicochemical characteristics of polyvinyl alcohol (PVA)-chitosan-based hydrogels. Hydrogels were formulated with varying concentrations of tannic acid of 1%, 3%, and 5%, then evaluated including organoleptic tests, pH, viscosity, spreadability, adhesion, swelling index, irritation test, and characterization using Fourier Transform Infrared (FTIR). The results showed that increasing the concentration of tannic acid caused the formation of a denser hydrogel network, which was characterized by a decrease in the swelling index value and an increase in adhesion and changes in viscosity. The pH values ​​of all formulas were within the physiological pH range of the skin. Irritation tests on 20 panelists showed that all formulas did not cause irritation reactions. FTIR analysis confirmed the presence of molecular interactions between PVA, chitosan, and tannic acid through hydrogen bond formation. Overall, variations in the concentration of tannic acid as a chemical crosslinker affected the physicochemical characteristics of the PVA–chitosan hydrogel and resulted in stable preparations with good quality
Co-Authors Az-zahra, Vivilia Delia, Faizha Putri Kuengo, Gerrald Hariyawan LATIF, MULTIANI S Marhaba, Zulkarnain Muhammad Taupik Nur Rasdianah Papeo, Dizky Ramadani Putri Suryadi, A. Mut’hi Andy Yusuf, Siti Rahmatia