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All Journal Jurnal Teknik Jambura Journal of Chemistry Jurnal Mandala Pharmacon Indonesia Journal Syifa Sciences and Clinical Research (JSSCR) Indonesian Journal of Pharmaceutical Education Jurnal Kolaboratif Sains Jurnal Pengabdian Masyarakat Farmasi : Pharmacare Society Journal of Pharmaceutical and Sciences. Jurnal Farmasi Teknologi Sediaan dan Kosmetika (JFTSK) Journal of Pharmacology and Natural Products
Papeo, Dizky Ramadani Putri
Universitas Negeri Gorontalo
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Isolasi dan Karakterisasi Bakteri Endofit dari Akar Pare (Momordica charantia L.) Mahdalena Sy. Pakaya; Julianty Akuba; Dizky Ramadani Putri Papeo; Andi Makkulawu; Ade Ari Puspitadewi
Journal Syifa Sciences and Clinical Research Vol 4, No 1 (2022): Volume 4 Edisi 1 2022
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/jsscr.v4i1.15536

Abstract

Endophytic bacteria are microbes that grow on plant tissue and can form a colony on plant tissue without producing a negative effect on the host. The endophytic bacteria have the potential to have the same activity and produce secondary metabolite as their host. The root of bitter melon (momordica charantia L.) has been known to have antibacterial activity, thus enabling the presence of endophytic bacteria, which also have antibacterial potential.This present research aims to isolate and characterize endophytic bacteria found in bitter melon (Momordica charantia L. The method used in the isolation stage is direct lanting so that the endophytic bacteria are obtained from plant tissue; macroscopic and microscopic characterization stage; inhibition test stage; inhibition test stage using disc method (Kirby-Bauer). In accordance with the results of macroscopic and microscopic characterization, the two bacteria indicate different characteristics.
Gambaran Penggunaan Obat Off-Label Pada Pasien Pediatrik Rawat Inap di Rumah Sakit Teti Sutriati Tuloli; Nur Rasdianah; Andi Makkulawu; Dizky Ramadani Putri Papeo; Maimun Datau
Indonesian Journal of Pharmaceutical Education Vol 2, No 2 (2022): Mei-Agustus 2022
Publisher : Jurusan Farmasi Universitas Negeri Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/ijpe.v2i2.11449

Abstract

Off-label drugs can be interpreted as drugs that are used not in accordance with drug information, distribution permits and sales licenses from the Marketing Authorization (MA) related to indications, age, dosage, route of administration and contraindications. The use of off-label drugs in children occurs because of incomplete data on pharmacokinetics, pharmacodynamics and side effect of a drug. It is because clinical research in children is quite difficult and not in accordance with research ethics and morals, so it has the potential to cause errors in treatment and unwanted drug reactions. This study aims to describe the use of off-label drugs in hospitalized pediatric patients at RSUD of Dr. M.M Dunda Limboto, Gorontalo District, Gorontalo Province. This is an  observational study using cross sectional design and retrospective data collection. The sampling technique applies a purposive sampling technique with a total of 155 patients who meet the inclusion criteria during the January-June 2020 period. The finding shows that from 155 patient medical records, there are 172 (16,51%) off-label drug used with a total of 1042 drugs. The off-label drugs used in the indication category are 64,53%, the off-label drugs used in dose category are 17,44%, the off-label drugs used in age category are 14,53%, the off-label drugs used in route of administration category are 3,49% and the off-label drugs used in contraindications category are not found. The are the most off-label drugs used in each category, including domperidone (off-label in indications and dose), rhinofed (off-label in age) and salbutamol (off-label in route of administration).
Pengaruh Variasi Konsentrasi Ekstrak Buah Mahkota Dewa (Phaleria macrocarpa) Terhadap Stabilitas Fisik Sediaan Krim Nur Ain Thomas; Robert Tungadi; Dizky Ramadani Putri Papeo; Andi Makkulawu; Yuni Sarah Manoppo
Indonesian Journal of Pharmaceutical Education Vol 2, No 2 (2022): Mei-Agustus 2022
Publisher : Jurusan Farmasi Universitas Negeri Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/ijpe.v2i2.13532

Abstract

God's crown is one of the plants with various components with flavonoid as one of these components, which is an abundant plant metabolite component in nature that significantly functions for the plant's growth and antioxidants. This study aimed to examine The Concentration Variation Effect of 70% Ethanol Extract from God's Crown (Phaleria Macrocarpa) Towards The Physical Stability of Cream Preparations by variating the extract concentration. The formula concentration on the extract consists of FI (1%), FII (3%), FIII (5%), by stearic acid, paraffin liquid, alcohol cetyl, paraben propyl for the oil phase, aquadest, triethanolamine (TEA), and methylparaben for the water phase. Further evaluations include organoleptic test (smell, color, texture), pH test, homogeneity test, viscosity test, distribution test, and adhesion test. Each evaluation result found changes as intended by the research purpose, which is the effect of the extract's concentration variation on the physical stability of the cream preparations.
Tingkat Pengetahuan Masyarakat Terhadap Tindakan Penggunaan Antibiotik Tanpa Resep Dokter Madania Madania; A. Mu’thi Andy Suryadi; Fika Nuzul Ramadhani; Andi Makkulawu; Dizky Ramadani Putri Papeo
Journal Syifa Sciences and Clinical Research Vol 4, No 3 (2022): Volume 4 Edisi 3 2022
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/jsscr.v4i3.7141

Abstract

Antibiotics is a subtance that can kill or weaken an organism such as bacteria, parasite, or fungi.  The use of antibiotics always triggers a problem, such as the use of it without any medical prescription. It sometimes happens caused by some factors such as the lack of people’s knowledge concerning the consumption of antibiotics. This research aims at investigating the correlation between the respondent’s characteristics toward knowledge, attitude, and action. Also, it is to investigate the correlation between knowledge and attitude toward the consumption of antibiotics without medical prescription. The research design applies analytical observation with cross sectional approach. The research subjects are 96 respondents selected by purposive sampling technique. The research instrument is questionnaires consisting of questionnaire of knowledge, attitude, and action. The method of data analysis is multiple correlation. Findings reveal that the people’s level of knowledge is still low obtaining 47,7% of score, the people’s attitude is categorized negative (supporting the consumption of antibiotics without medical) obtaining 54,2%, the people’s action categorized not appropriate obtaining 57,3%, there is correlation between education and job toward knowledge, attitude, and action (p0,05), there is no correlation between age and sex toward knowledge, attitude, and action (p0,05), and there is a correlation between knowledge and attitude toward action (p=0,000).
Efek Antihiperurisemia Ekstrak Etanol Daun Pandan (Pandanus Amaryllifolius ) Pada Mencit (Mus Musculus) Widysusanti Abdulkadir; Dizky Ramadani Putri Papeo; Juliyanty Akuba; Andi Makkulawu
Journal Syifa Sciences and Clinical Research Vol 4, No 2 (2022): Volume 4 Edisi 2 2022
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/jsscr.v4i2.7719

Abstract

Hyperuricemia is a condition in which the kidneys fail to excrete uric acid, resulting in high levels of uric acid. (Kaneko et al., 2014). Uric acid will be excreted into the kidneys along with urine. The decrease of uric acid secretion into the kidney tubules due to interference of uric acid elimination to the kidneys which causes uric acid levels in the blood to increase (Ningtiyas Ramadhian, 2016). An adult male is suffering from hyperuricemia when his serum uric acid level is more than 7.0 mg/dl, while hyperuricemia in adult women occurs when the serum uric acid level is above 6.0 mg/dl. Hyperuricemia therapy management in the community is very diverse, ranging from traditional medicines and synthetic drugs. One of the traditional plants used as traditional medicine is pandan leaves. This study aimed to determine the anti-hyperuricemia effect of ethanol extract of Pandanus amaryllifolius leaves on mice (Mus musculus L.). The study involved 25 male mice which were divided into 5 groups; each group consisted of five male mice. Group I was a negative control with Na-CMC 1% w/v, while Group II was a positive control with Allopurinol 0.117 g w/v. Further, Groups III, IV, and V were given Ethanol Extract of 0.5 gr w/v, 1 g w/v, 1.5 g w/v of Pandan Leaves, respectively. The results showed that there was no significant decrease in uric acid levels in group I. Meanwhile, Groups II, III, IV, and V showed a significant reduction in uric acid levels with identical effectiveness. The results of the study were then tested using the One-Way ANOVA statistical test; the p-value was 0.01 (α 0.01). The best dose was 1.5 g of extract since there was a significant difference from the pandan leaves extract with 1.5 g (p 0.01). In conclusion, pandan leaves extract can reduce uric acid levels in the blood. This was evidenced by a decrease of 4.1 mg/dl in uric acid levels in mice during the experiment.
Isolasi dan Karakterisasi Jamur Endofit Lamun (Thalassia hemprichii) Dari Kawasan Teluk Tomini Mahdalena Sy. Pakaya; Wiwit Zuriati Uno; Dizky Ramadani Putri Papeo; Dewi Rahmawaty Moo
Journal Syifa Sciences and Clinical Research Vol 4, No 3 (2022): Volume 4 Edisi 3 2022
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/jsscr.v4i3.15852

Abstract

Endophytic fungi live in their host tissues. Endophytic fungi can produce compounds similar to their hosts as well. In this case, the use of endophytic fungi can reduce the exploitation of seagrass (Thalassia hemprichii) populations in Tomini Bay. This study aims to isolate and determine the characteristics of the endophytic fungus of seagrass (Thalassia hemprichii) from the Tomini Bay area. The test method used is the isolation and characterization macroscopically and microscopically. The results of the isolation obtained two isolates of endophytic fungi coded J1 and J2 with different characteristics. The isolate code J1 had microscopic characteristics of a yeast-like shape, while the isolate code J2 had the characteristic of non-septate hyphae.
Edukasi Penggunaan Obat Antidiabetes di Bulan Ramadhan pada Masyarakat Desa Buata Kecamatan Botupingge Widy Susanti Abdulkadir; Nur Ain Thomas; Dizky Ramadani Putri Papeo
Jurnal Pengabdian Masyarakat Farmasi : Pharmacare Society Vol 1, No 1 (2022): Vol 1 Edisi 1 2022
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (909.881 KB) | DOI: 10.3731/phar.soc.v1i1.14039

Abstract

Permasalahan utama pasien Diabetes Melitus (DM) adalah kepatuhan dalam minum obat dalam jangka Panjang. Pasien diabetes melitus yang mendapat terapi obat antidiabetes oral yang dapat menjalankan ibadah puasa di bulan Ramadhan harus mengikuti aturan baru minum obat, sehingga perlu diberikan informasi mengenai aturan minum obat yang tepat. Pemberian informasi melalui penyebaran brosur merupakan salah satu cara yang paling efektif untuk memperkenalkan aturan pemberian obat yang benar. Kegiatan tersebut berlokasi di Desa Buata, Kecamatan Botupingge, Kabupaten Bone Bolango. Hasil dari kegiatan ini, penderita diabetes melitus lebih siap menghadapi Ramadhan dengan aturan baru minum obat anti diabetes.
Pelatihan Pembuatan Tepung Kulit Pepaya sebagai Bahan Dasar Nuget untuk Mencegah Stunting di Desa Huntu Selatan, Kabupaten Bone Bolango Elvie Febriani Dungga; Dizky Ramadani Putri Papeo; Gusti Pandi Liputo
Jurnal Pengabdian Masyarakat Farmasi : Pharmacare Society Vol 1, No 3 (2022): Vol 1 Edisi 3 (2022)
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (732.055 KB) | DOI: 10.3731/phar.soc.v1i3.18476

Abstract

Data stunting di Provinsi Gorontalo berturut-turut mengalami penurunan dari tahun 2018, 32,5% menjadi 29,0% pada tahun 2021, namun masalah stunting masih menjadi persoalan serius di Gorontalo. Desa Huntu Selatan yang berlokasi di Kabupaten Bone Bolango merupakan desa yang berdekatan dengan ibu kota provinsi, walaupun demikian pada tahun 2022 tercatat ada 6 orang balita yang menderita stunting. Pencegahan stunting dapat dilakukan dengan melengkapi nutrisi sejak bayi berada dalam kandungan ibunya, selama proses menyusui hingga masa MPASI pada bayi. Salah satu sumber makanan dengan kandungan gizi yang diperlukan terdapat pada kulit buah pepaya yang banyak ditanam sebagai komoditi lokal di Desa Huntu Selatan. Pemanfaatan buah pepaya menghasilkan limbah kulit pepaya yang terbuang sehingga perlunya suatu pelatihan dalam pengolahan limbah kulit pepaya tersebut. Limbah kulit pepaya dapat diolah menjadi tepung yang dapat digunakan sebagai alternatif tepung terigu. Tepung kulit papaya yang dihasilkan kemudian digunakan sebagai bahan dasar pembuatan nuget untuk meningkatkan cita rasa dan tekstur dari olahan nuget.
Evaluasi Tingkat Terhadap Pengetahuan Sikap dan Tindakan terhadap Swamedikasi : Studi Kasus Kecamatan Una-Una Provinsi Sulawesi Tengah Dizky Ramadani Putri Papeo; Teti Sutriati Tuloli
Journal Syifa Sciences and Clinical Research Vol 5, No 1 (2023): Volume 5 Edisi 1 2023
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/jsscr.v5i1.9817

Abstract

Self-medication is an attempt to use drugs by a person to treat ailments or minor symptoms such as fever, dizziness, cough, influenza, and other diseases using modern and traditional medicines without a doctor's prescription or recommendation.The purpose of this study was to describe the knowledge, attitudes, and actions of self-medication carried out by the community. This was a descriptive cross-sectional study with a total sample of 93 respondents taken by purposive sampling. Data were collected by filling out a questionnaire that had been tested for validity and reliability.The results showed that the majority of respondents in Una-Una District, Central Sulawesi Province were women (57%) with a majority age range between 40 - 50 years (33%), with High School/Vocational/Islamic High School educational background (33%), and had different jobs (40%). The level of knowledge, attitudes, and actions of the community regarding self-medication was classified as good with the percentage of the knowledge level of 61%, the attitude level of 57%, and the level of action of 74%.
Pengolahan Limbah Tulang Ikan Tongkol menjadi Tepung Tinggi Kalsium : Waste Treatment of Tuna Fish Bone into High Calcium Flour Tri Septian Maksum; Dizky Ramadani Putri Papeo
Jurnal Kolaboratif Sains Vol. 6 No. 9: SEPTEMBER 2023
Publisher : Universitas Muhammadiyah Palu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56338/jks.v6i9.4116

Abstract

Kabupaten Boalemo memiliki potensi sumberdaya alam yang cukup besar khususnya pada sektor perikanan dan kelautan, dan ikan tongkol (Euthynnus affinis) menjadi salah satu produksi ikan yang menjadi andalan bagi masyarakat setempat. Tulang ikan merupakan salah satu produk sampingan dalam proses pengolahan ikan, namun memiliki kandungan kalsium terbanyak diantara bagian tubuh ikan yang lain. Salah satu bentuk pemanfaatan tulang ikan yaitu dengan mengolahnya menjadi tepung tulang ikan. Kegiatan pengabdian kepada masyarakat ini bertujuan untuk meningkatkan kemandirian masyarakat pesisir Desa Pentadu Timur Kecamatan Tilamuta Kabupaten Boalemo Provinsi Gorontalo melalui edukasi dan pelatihan/simulasi pengolahan limbah tulang ikan tongkol menjadi tepung tinggi kalsium. Metode yang digunakan berupa ceramah, tanya jawab, diskusi, dan praktik/simulasi. Lokasi kegiatan di Desa Pentadu Timur Kecamatan Tilamuta Kabupaten Boalemo Provinsi Gorontalo, yang akan berlangsung selama 48 hari terhitung mulai 17 Juli – 2 September 2023. Hasil pengabdian menunjukkan nilai rata-rata saat pre-test adalah 52,25 dan meningkat menjadi 84,50 pada saat post-test. Nilai maksimal yang dihasilkan oleh peserta juga meningkat dari 60 menjadi 100. Sementara itu, pada program simulasi, masyarakat sudah mampu dalam membuat/mengolah limbah tulang ikan tongkol menjadi produk tepung tinggi kalsium, serta mampu mengemas dan memasarkan produk secara mandiri, sehingga seluruh rangkaian kegiatan dinilai berhasil.
Co-Authors A. Mu’thi Andy Suryadi Abd. Ghiaz Putra Ramadan Ahmad Ade Ari Puspitadewi Ahmad Rifly Suleman Akuba, Juliyanti Andi Makkulawu Andini Putri Sabihi Arini Arini Chinta Suryaningrum Dewi Rahmawaty Moo Elvie F Dungga Endah Nurrohwinta Djuwarno Erika Dami Fhigra Marfiah Fika Nuzul Ramadhani Gunawan, Selvi Ayu Setiaarini Gusti Pandi Liputo Hamsidar Hasan Hiola, Faramita Immaculata, Maria Indhitya R Padiku Intan Nusi Ishak Isa Julianty Akuba Kadaria Toana Kasim, Sesha Ramadhani Lia Amalia Lillyan Hadjaratie Madania, Madania Mahdalena Sy Pakaya Maimun Datau Muh. Fikri F. Walahe Muhammad Taupik Muhammad Taupik Multiani S. Latif Nabila Novreini Djunaidi Nur Ain Thomas Nur Rasdianah Nur'ain Dj. Silaka Nurhayati Salam Rahmatia Samatowa Rezky Nur Aziz Robert Tungadi Rukmawati, Iis Teti Sutriati Tuloli Teti Sutriyati Tuloli Tri Septian Maksum Widy Susanti Abdulkadir Widy Susanti Abdulkadir Widy Susanti Abdulkadir Widysusanti Abdulkadir Windy Riani Suleman Wiwit Zuriati Uno Yuni Sarah Manoppo Zulkarnain Marhaba