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All Journal Contagion: Scientific Periodical Journal of Public Health and Coastal Health
Sinaga, Perwita Sari
Master's Program in Tropical Medicine, Faculty of Medicine, Dentistry, and Health Sciences, Universitas Prima Indonesia
Health Professions Public Health

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Prognostic Value of the Neutrophil–Lymphocyte Ratio for 28-Day Mortality in Hospitalized Pulmonary Tuberculosis Nasution, Ali Napiah; Sinaga, Perwita Sari; Nasution, Sri Wahyuni
Contagion: Scientific Periodical Journal of Public Health and Coastal Health Vol 8, No 1 (2026): CONTAGION
Publisher : Universitas Islam Negeri Sumatera Utara, Medan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30829/contagion.v8i1.26437

Abstract

Pulmonary tuberculosis (TB) remains a leading cause of infectious mortality. The neutrophil–lymphocyte ratio (NLR) is an accessible inflammatory index that may stratify short-term risk in hospitalized TB. To examine whether admission NLR predicts 28-day mortality in pulmonary TB. We conducted a retrospective cohort at Royal Prima General Hospital, Medan (1 January 2023–31 December 2024), among adults (18–65 years) admitted with active pulmonary TB. Demographics, TB category, day-1 neutrophil and lymphocyte counts (to derive NLR), and 28-day outcomes were abstracted from medical records. NLR was analyzed as a continuous variable and as a binary variable using a receiver operating characteristic (ROC)-derived cut-off. Group comparisons used t/Mann–Whitney tests as appropriate; prognostic performance was assessed by area under the ROC curve (AUC). The results of the analysis show that NLR has a significant ability to identify patients at risk of death during treatment. This finding has important implications for clinical management, where the use of NLR as a routine biological marker can assist medical personnel in triage and more timely therapeutic decision-making. Therefore, the application of this parameter is expected to help reduce mortality rates through closer monitoring of high-risk patient groups. Keywords: Pulmonary Tuberculosis, Neutrophil–Lymphocyte Ratio, 28-Day Mortality, Prognosis, Biomarkers.
Co-Authors Nasution, Ali Napiah Nasution, Sri Wahyuni