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Amanatus Solikhhah
Department of Clinical Pathology, Faculty of Medicine, Ahmad Dahlan University
Medicine & Pharmacology

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PROGRESSION OF CHRONIC LYMPHOCYTIC LEUKEMIA TO PROLYMPHOCYTIC LEUKEMIA: A RARE CASE REPORT Amanatus Solikhhah; Nur Imma Fatimah Harahap
Jurnal Kedokteran Diponegoro (Diponegoro Medical Journal) Vol 14, No 5 (2025): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL)
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dmj.v14i5.51237

Abstract

Background: Chronic lymphocytic leukemia, or CLL, is a chronic hematological malignancy marked by the overproduction of mature but nonfunctional lymphocytes. This condition is uncommon among Asian individuals. As a result, variations of this type of CLL are even less frequently observed. A CLL that presents with prolymphocytic progression is now recognized as a new illness in in the fifth edition of the World Health Organization classification. It is identified as a CD5+ non-mantle B-cell tumor featuring a minimum of 15% prolymphocytes in the bloodstream or bone marrow, and it partially supersedes the previous classification of B-cell prolymphocytic leukemia. Case Presentation: A 78-year-old woman experiencing increasing fatigue and difficulty breathing was brought to the emergency room and subsequently found to have Chronic lymphocytic leukemia. In this report, we highlight an uncommon instance of prolymphocytic leukemia advancement in a CLL patient within an exceptionally brief period of one week. Conclusion: Prolymphocytic transformation of CLL is a rare case with poor prognosis.This change was illustrated by the presence of undeveloped cells found in the peripheral blood, resembling prolymphocytes. The CLL patient unfortunately passed away shortly after being admitted to the hospital for a few days, which is atypical for traditional CLL patients who generally experience a longer duration of life. Thus, it is necessary to monitor the number of prolymphocyte in CLL patient as indicator of poorer transformation of chronic leukemia.
ASSOCIATION BETWEEN ADMISSION D-DIMER LEVELS AND MORTALITY IN COVID-19 Amanatus Solikhhah; Rizka Ariani; Mulat Muliasih
Jurnal Kedokteran Diponegoro (Diponegoro Medical Journal) Vol 15, No 4 (2026): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL)
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dmj.v15i4.53896

Abstract

Background: It is possible that specific laboratory test results could indicate the likelihood of death from COVID-19. Objective: The main goal of this research was to figure out if measuring D-dimer levels could help forecast the likelihood of death for individuals suffering from COVID-19. Methods: A backward-looking study of a group of people based on observations, encompassing 317 individuals, was conducted utilizing existing data extracted from the health documents of COVID-19 inpatients. The concentration of D-dimer was acquired via patient's blood test results upon initial admittance to the medical facility. Following this, patients were divided into two categories: those who lived (comprising 252 individuals) and those who did not (consisting of 66 individuals), according to the end result. Proportions and central values were assessed employing Kolmogorov-Smirnov. Logistic regression was applied to ascertain if there exists a noteworthy disparity in D-dimer concentrations among different mortality statuses. Results: The cohort that did not survive showed a notably elevated presence of D-dimer (Odds Ratio 6.480 ;p<0.001). Conclusion: The starting assessment of D-dimer levels might be useful in spotting individuals who face increased vulnerability and help guide choices concerning critical care management.
Co-Authors Mulat Muliasih Nur Imma Fatimah Harahap Rizka Ariani