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All Journal JOPS (Journal Of Pharmacy and Science) Jurnal Kajian Ilmiah Kesehatan Dan Teknologi (JKIKT) Abdimas Toddopuli: Jurnal Pengabdian Pada Masyarakat Jurnal Pengabdian dan Pemberdayaan Kesehatan JI-KES (Jurnal Ilmu Kesehatan) Jurnal Farmasi Udayana
Vivi Shofia
Universitas Hafshawaty Zainul Hasan
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Civil Engineering, Building, Construction & Architecture Computer Science & IT Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health Other

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Literatue Review : Biochemical and Pharmacological Prospects of Enhalus acoroides as a Source of Antifibrotic Compounds for National Drug Development Vivi Shofia
Jurnal Farmasi Udayana Vol. 14, Issui 2, Tahun 2025
Publisher : Departement of Pharmacy, Faculty of Mathematics and Natural Science, Udayana University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/JFU.2025.v14.i02.p02

Abstract

Fibrosis is a progressive pathological process characterized by excessive accumulation of extracellular matrix and represents a major cause of organ failure, including in the kidney, liver, and lung. Currently available antifibrotic therapies have limited efficacy and are associated with potential adverse effects, highlighting the urgent need for new drug candidates derived from natural sources. The seagrass Enhalus acoroides, which is abundant in Indonesian waters, has been reported to contain flavonoids, polyphenols, sterols, and bioactive fatty acids that may modulate oxidative stress and inflammation, two key mechanisms involved in fibrogenesis. This review aims to evaluate the biochemical and pharmacological potential of E. acoroides as a source of antifibrotic compounds for national drug development. The methodology involved a literature review of scientific databases focusing on phytochemical profiles, pharmacological activities, and molecular mechanisms related to fibrosis. The findings indicate that E. acoroides exhibits significant antioxidant and antibacterial activities, contains major secondary metabolites (notably flavonoids and phenolics), and shows mechanistic relevance to the TGF-β/Smad signaling pathway, a central regulator of fibrogenesis. In conclusion, E. acoroides has promising potential as a candidate antifibrotic phytopharmaceutical; however, further validation through in vitro, in vivo, and advanced pharmaceutical formulation studies is required
Edukasi Bahan Kimia Berbahaya dalam Produk Makanan dan Kosmetik untuk Kader Desa Kedungsari, Kecamatan Maron, Kabupaten Probolinggo Vivi Shofia; Bela Khofidatu Tazkiyah; Wardatul Jannah
Abdimas Toddopuli: Jurnal Pengabdian Pada Masyarakat Vol. 7 No. 1 (2025): Volume 7, No 1, Desember 2025
Publisher : Universitas Cokroaminoto Palopo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30605/atjpm.v7i1.7220

Abstract

Permasalahan mitra yaitu kader desa di Kedungsari, Kecamatan Maron, adalah keterbatasan pengetahuan tentang identifikasi zat kimia berbahaya (seperti formalin, rodamin B, merkuri) dalam produk pangan dan kosmetik, serta kurangnya keterampilan dan media untuk edukasi masyarakat. Tujuan pengabdian ini adalah meningkatkan kapasitas kader dalam mengenali bahaya bahan kimia berbahaya dan metode penyampaian informasi yang efektif. Metode yang digunakan meliputi edukasi partisipatif dengan pretest-posttest, paparan materi menggunakan powerpoint dan pembagian leaflet. Hasil kegiatan menunjukkan peningkatan signifikan pengetahuan kader, dimana lebih dari 80% peserta mengalami peningkatan skor posttest. Selain itu, terjadi perubahan sikap dan praktik, seperti kesadaran membaca label produk dan komitmen untuk mengedukasi masyarakat. Kegiatan ini berhasil membentuk kader sebagai agen perubahan kesehatan di komunitasnya. Disarankan pelatihan berkelanjutan dan pengembangan media digital untuk memperluas dampak program.
Remaja Cegah TBC Sejak Dini dan Gerakan Sekolah Sehat di SMA Unggulan Zaha Umi Fatmawati; Vivi Shofia; Listiana Azizah; Nadira Nadira
Jurnal Pengabdian dan Pemberdayaan Kesehatan Vol. 3 No. 2 (2026): Juni 2026
Publisher : Menara Science Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70109/jupenkes.v3i2.119

Abstract

Tuberkulosis (TBC) paru masih menjadi tantangan kesehatan masyarakat di Indonesia, termasuk di Kabupaten Probolinggo yang menunjukkan peningkatan kasus signifikan dalam tiga tahun terakhir, yaitu dari 1.193 kasus (2021) menjadi 2.493 kasus (2023). Kelompok remaja dan pelajar menjadi populasi rentan karena mobilitas tinggi, kurangnya kesadaran perilaku hidup bersih dan sehat (PHBS), serta pengetahuan yang terbatas tentang tanda, gejala, dan tatalaksana TBC. Kegiatan Pengabdian Kepada Masyarakat (PKM) ini bertujuan untuk meningkatkan pengetahuan dan kesadaran siswa tentang pencegahan TBC serta mendorong penerapan PHBS di lingkungan sekolah. Metode pelaksanaan meliputi tahap persiapan (koordinasi mitra, identifikasi sasaran, pembuatan leaflet dan instrumen), tahap pelaksanaan (penyuluhan interaktif, diskusi, pembagian leaflet, serta pengisian pre-test dan post-test), dan tahap evaluasi. Kegiatan dilaksanakan pada tanggal 12 November 2025 di SMA Unggulan BPPT Zaha, Pajarakan, Probolinggo, dengan peserta 14 siswa. Hasil kegiatan menunjukkan sebelum edukasi (pre-test), tingkat pengetahuan siswa beragam dengan nilai rata-rata 66,43%; sebanyak 4 siswa (28,6%) berkategori sangat baik, 5 siswa (37,5%) baik, 3 siswa (21,4%) cukup baik, dan 2 siswa (14,3%) kurang baik. Setelah edukasi (post-test), terjadi peningkatan signifikan dengan rata-rata nilai menjadi 92,29% (peningkatan 32,86%). Seluruh siswa (100%) mencapai kategori sangat baik (nilai ≥80). Siswa mampu memahami penyebab TBC (Mycobacterium tuberculosis), cara penularan melalui droplet, gejala batuk berkepanjangan, serta pentingnya pengobatan tuntas selama 6 bulan dan penerapan etika batuk. Kegiatan ini terbukti efektif dalam meningkatkan pemahaman dan kesadaran siswa tentang pencegahan TBC sejak dini serta mendorong perubahan perilaku menuju gaya hidup bersih dan sehat. Luaran kegiatan berupa publikasi ilmiah.
Exploring the Therapeutic Potential of Shallot Extract in Gastritis Vivi Shofia; Fahmi Dimas Abdul Azis; Adek Bela Anggraeni; Hamida Nurlaila
JURNAL FARMASI DAN MAKANAN Vol 8 No 2 (2025): Journal of Pharmacy and Science
Publisher : LPPM Universitas Abdurrab

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36341/jops.v8i2.6193

Abstract

Gastritis, commonly known as stomach ulcers, is a widespread condition caused by poor eating habits, certain foods, infections, and NSAID use. In Indonesia, WHO reports a 40.8% prevalence, making it a major health issue. This study aimed to evaluate the effects of ethanol-extracted shallot (Allium sp.) skin and bulb on malondialdehyde (MDA) levels and gastric histopathology in rats with indomethacin-induced gastritis. Gastritis was induced in Rattus norvegicus, followed by treatment with shallot extract. MDA levels and tissue damage were then analyzed using Hematoxylin-Eosin staining. Results showed a significant reduction in MDA levels, especially with 200 mg/kg body weight of shallot skin extract, which achieved a 92.18% decrease. Histopathological analysis revealed notable improvements in gastric tissue, with reduced ulceration and inflammation. The findings support the potential of shallot extract in lowering oxidative stress and repairing gastric damage, suggesting its promise as an alternative therapy for gastritis.
Potensi Ekstrak Etanol Kulit Bawang Merah terhadap Kadar Malondialdehid Jejunum Tikus Gastritis Endah Sulistyorini; Umi Narsih; Vivi Shofia
JI-KES (Jurnal Ilmu Kesehatan) Vol. 9 No. 1 (2025): JI-KES (Jurnal Ilmu Kesehatan)
Publisher : LPPM Universitas Hafshawaty Zainul Hasan Probolinggo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33006/ji-kes.v9i1.894

Abstract

Abstrak Gastritis adalah peradangan mukosa lambung yang ditandai dengan peningkatan stress oksidatif dan kadar malondialdehid. Angka kejadian gastritis pada beberapa daerah di Indonesia cukup tinggi dengan prevalensi 274.396 kasus dari 238.45.952 jiwa penduduk setiap tahun. Kulit bawang merah (Allium sp.) mengandung senyawa antiinflamasi dan antioksidan yang berpotensi untuk pengobatan gastritis. Penelitian ini bertujuan mengetahui potensi ekstrak etanol kulit bawang merah dalam menurunkan kadar malondialdehid jejunum tikus putih (Rattus norvegicus) model gastritis. Metode penelitian ini menggunakan desain eksperimental research dengan rancangan post-test only control group design. Sebanyak 25 tikus dibagi dalam 5 kelompok, yakni kelompok tikus sehat, kelompok tikus gastritis, kelompok terapi ranitidin, kelompok terapi ekstrak kulit bawang merah dosis 100 dan 200 mg/kgBB. Kadar malondialdehid dianalisis dengan spektrofotometri UV-Vis. Hasil penelitian menunjukkan penurunan signifikan kadar malondialdehid pada kelompok dengan terapi ekstrak kulit bawang merah dosis 100 mg/kgBB dan 200 mg/kgBB yaitu penurunan sebesar 52,52% (1,313 ± 0,393)  pada dosis 100 mg/kgBB dan 61,69% (1,059 ± 0,264) pada dosis 200 mg/kgBB. Berdasarkan hasil penelitian, ekstrak etanol kulit bawang merah berpotensi sebagai agen antioksidan dan antiinflamasi dalam menurunkan kadar MDA pada kondisi gastritis. Kata kunci: gatritis, stress oksidatif, malondialdehid, tikus, kulit bawang merah   Abstract Gastritis is an inflammation of gastric mucosa characterized by increased oxidative stress and elevated levels of malondialdehyde (MDA). The number of gastritis cases in Indonesia is relatively high, with a prevalence of 274,396 cases among a population of 238,459,952 annually. Shallot peel (Allium sp.) contains anti-inflammatory and antioxidant compounds that have potential for treating gastritis. This study aimed to determine the potential of ethanol extract of shallot peel in reducing malondialdehyde levels in jejunum of white rats (Rattus norvegicus) with gastritis models. This research used an experimental design with a post-test only control group design. A total of 25 male white rats were divided into five groups: negative control, positive control, ranitidine therapy group, and treatment groups receiving shallot peel ethanol extract at doses of 100 mg/kgBW and 200 mg/kgBW. Malondialdehyde levels were analyzed using UV-Vis spectrophotometry. The results showed a significant decrease in malondialdehyde levels in the groups treated with shallot peel extract at doses of 100 mg/kgBW and 200 mg/kgBW, with reductions of 52.52% (1.313 ± 0.393) and 61.69% (1.059 ± 0.264), respectively. Based on these findings, ethanol extract of shallot peel has potential as an antioxidant and anti-inflammatory agent in reducing MDA levels under gastritis conditions. Keywords: gastritis, oxidative stress, malondialdehyde, mouse, shallot peel
ANALISIS TOKSIKOLOGI BAHAN KIMIA OBAT DALAM JAMU TRADISIONAL: PENDEKATAN MELALUI KROMATOGRAFI LAPIS TIPIS: Toxicological Analysis of Synthetic Drug Adulterants in Traditional Herbal Medicine: An Approach Using Thin Layer Chromatography Hilmia Lukman; Vivi Shofia
Jurnal Kajian Ilmiah Kesehatan dan Teknologi Vol. 8 No. 1 (2026)
Publisher : Politeknik Unggulan Kalimantan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52674/ae5d9y26

Abstract

Traditional herbal medicines are widely used due to their perceived safety and natural origin; however, illegal addition of pharmaceutical substances such as paracetamol and sodium diclofenac poses adverse health effects. The objective of this study was to determine whether paracetamol and sodium diclofenac were present in jamu pegal linu samples via Thin Layer Chromatography (TLC) analysis. The study obtained all samples from local herbal stores in Pajarakan, Probolinggo. TLC analysis on silica gel GF254 plates was performed with compound-specific solvent systems: a 4:1 (v/v) ethyl acetate-chloroform mixture for paracetamol, and a 3:2 (v/v) ethyl acetate-n-hexane mixture for sodium diclofenac. Results revealed paracetamol was detected in three out of four samples with a retardation factor (Rf) of 0.61, while sodium diclofenac was found in three samples with Rf values around 0.90. One sample showed no presence of both compounds. These findings indicate illegal adulteration of herbal medicine, which may cause liver toxicity, kidney impairment, and cardiovascular risks. Therefore, strict supervision and consumer education are essential to prevent adverse health impacts.
Penentuan KHM dan KBM Ekstrak Etanol Daun Mimba (Azadirachta indica A.Juss) terhadap Staphylococcus Aureus Shinta Nova Salsabila; Fahmi Dimas Abdul Azis; Vivi Shofia
JI-KES (Jurnal Ilmu Kesehatan) Vol. 10 No. 1 (2026): JI-KES (Jurnal Ilmu Kesehatan)
Publisher : LPPM Universitas Hafshawaty Zainul Hasan Probolinggo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33006/ji-kes.v10i1.1050

Abstract

Abstrak Daun mimba (Azadirachta indica A.Juss.) merupakan tanaman yang berpotensi sebagai antibakteri karena mengandung berbagai senyawa metabolit sekunder. Penelitian ini bertujuan untuk mengetahui kandungan senyawa fitokimia ekstrak etanol daun mimba serta menentukan aktivitas antibakterinya terhadap Staphylococcus aureus berdasarkan nilai Konsentrasi Hambat Minimum (KHM) dan Konsentrasi Bunuh Minimum (KBM). Penelitian ini merupakan penelitian eksperimental laboratorik. Ekstrak etanol daun mimba diperoleh melalui metode maserasi menggunakan etanol 96%. Uji fitokimia dilakukan secara kualitatif, sedangkan aktivitas antibakteri diuji menggunakan metode dilusi cair pada media Mueller Hinton Broth (MHB) dengan variasi konsentrasi ekstrak 8%, 4%, 2%, 1%, 0,5%, dan 0,25% untuk menentukan KHM, kemudian dilanjutkan dengan penanaman pada media Mueller Hinton Agar (MHA) untuk menentukan KBM. Hasil penelitian menunjukkan bahwa ekstrak etanol daun mimba mengandung flavonoid, alkaloid, saponin, dan terpenoid serta memiliki aktivitas antibakteri terhadap Staphylococcus aureus. Nilai KHM diperoleh pada konsentrasi 1%, sedangkan nilai KBM pada konsentrasi 2%. Dengan demikian, ekstrak etanol daun mimba berpotensi sebagai sumber antibakteri alami terhadap Staphylococcus aureus. Kata kunci: azadirachta indica; antibakteri; staphylococcus aureus; KHM; KBM   Abstract Neem (Azadirachta indica A.Juss.) is a medicinal plant with antibacterial potential attributed to its diverse secondary metabolites. This study aimed to identify the phytochemical constituents of the ethanolic neem leaf extract and to evaluate its antibacterial activity against Staphylococcus aureus by determining the Minimum Inhibitory Concentration (MIC) and Minimum Bactericidal Concentration (MBC). This was an in vitro laboratory experiment. Qualitative phytochemical screening was conducted. Antibacterial activity was assessed using the broth dilution method in Mueller Hinton Broth (MHB) at extract concentrations of 8%, 4%, 2%, 1%, 0.5%, and 0.25% to determine the MIC, followed by subculturing on Mueller Hinton Agar (MHA) to determine the MBC. The ethanolic neem leaf extract contained flavonoids, alkaloids, saponins, and terpenoids, and demonstrated antibacterial activity against Staphylococcus aureus. The MIC and MBC were 1% and 2%, respectively. These findings suggest that ethanolic neem leaf extract has potential as a natural antibacterial agent against Staphylococcus aureus. Keywords: azadirachta indica; neem leaves; antibacterial; staphylococcus aureus; MIC; MBC
Efek Ekstrak Temulawak terhadap Malondialdehid Serum Tikus Betina Model Induksi Estradiol Titis Maysaroh; Fahmi Dimas Abdul Azis; Vivi Shofia
JI-KES (Jurnal Ilmu Kesehatan) Vol. 10 No. 1 (2026): JI-KES (Jurnal Ilmu Kesehatan)
Publisher : LPPM Universitas Hafshawaty Zainul Hasan Probolinggo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33006/ji-kes.v10i1.1058

Abstract

Abstrak Stres oksidatif terjadi akibat ketidakseimbangan antara produksi reactive oxygen species (ROS) dan kapasitas antioksidan tubuh, yang memicu kerusakan sel melalui peroksidasi lipid. Kadar malondialdehid (MDA) digunakan sebagai penanda kondisi ini. Pemberian estradiol dapat meningkatkan ROS dan MDA. Temulawak (Curcuma xanthorrhiza Roxb.) mengandung kurkuminoid dan xanthorrhizol yang bersifat antioksidan dan antiinflamasi. Penelitian ini bertujuan mengevaluasi efek natrium diklofenak dan ekstrak etanol temulawak terhadap kadar MDA serum tikus betina yang diinduksi estradiol, serta menentukan dosis terbaik. Menggunakan desain post-test only control group, 25 tikus Wistar dibagi menjadi lima kelompok: kontrol negatif, kontrol positif (natrium diklofenak 10 mg/kgBB), dan perlakuan ekstrak temulawak dosis 250, 500, dan 1000 mg/kgBB. Kadar MDA diukur dengan metode TBARS menggunakan spektrofotometri UV-Vis, lalu dianalisis dengan Kruskal–Wallis dan Mann–Whitney. Hasil menunjukkan perbedaan signifikan antar kelompok (p=0,000). Natrium diklofenak dan ekstrak temulawak menurunkan MDA dibandingkan kontrol negatif. Dosis 1000 mg/kgBB memberikan penurunan terbesar, setara dengan diklofenak (p>0,05). Simpulannya, ekstrak etanol temulawak efektif menurunkan MDA serum tikus yang diinduksi estradiol, dengan dosis 1000 mg/kgBB sebagai yang efektif. Kata kunci: temulawak; natrium diklofenak; estradiol; malondialdehid; tikus putih   Abstract Oxidative stress results from an imbalance between the production of reactive oxygen species (ROS) and the body's antioxidant capacity, which triggers cell damage through lipid peroxidation. Malondialdehyde (MDA) levels are widely recognized as biomarkers of this condition. Estradiol administration may elevate ROS and MDA levels. Curcuma xanthorrhiza Roxb.(Temulawak) contains curcuminoids and xanthorrhizole which exhibit antioxidant and anti-inflammatory properties. This study aimed to evaluate the effect of diclofenac sodium and temulawak ethanol extract on the serum MDA levels of estradiol-induced female rats, as well as determine the best dose. Using a post-test only control group design involving 25 Wistar mice divided into five groups: negative control, positive control (sodium diclofenac 10 mg/kgBB), and cucumin extract treatment at doses of 250, 500, and 1000 mg/kgBB. MDA levels were measured using the TBARS method using UV-Vis spectrophotometry, and then analyzed with Kruskal–Wallis and Mann–Whitney. Results showed significant differences among groups (p=0.000). Sodium diclofenac and curcuma extract lowered MDA compared to negative controls. A dose of 1000 mg/kgBB provided the greatest reduction, equivalent to diclofenac (p>0.05). In conclusion, temulawak ethanol extract effectively reduced estradiol-induced serum MDA levels in rats, with 1000 mg/kgBW identified as the most effective dose. Keywords: curcuma xanthorrhiza; malondialdehyde; oxidative stress; estradiol; diclofenac sodium
Co-Authors Adek Bela Anggraeni Bela Khofidatu Tazkiyah Endah Sulistyorini Fahmi Dimas Abdul Azis Fahmi Dimas Abdul Azis Hamida Nurlaila Hilmia Lukman Listiana Azizah Nadira Nadira Shinta Nova Salsabila Titis Maysaroh Umi Fatmawati Umi Narsih Wardatul Jannah