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All Journal Jurnal Riset Kefarmasian Indonesia Jurnal Farmasi Ikifa
Yetri Elisya
Poltekkes Kemenkes Jakarta II
Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health

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LITERATURE STUDY ON ANTIHYPERTENSIVE THERAPY IN PREGNANCY Junaedi; Nanang Kurnia Achmadi; Yetri Elisya; Dwi Yunita Rizki Fajarsari
Jurnal Farmasi IKIFA Vol. 3 No. 3 (2024): JURNAL FARMASI IKIFA VOL.3 NO.2 OKTOBER TAHUN 2024
Publisher : Sekolah Tinggi Ilmu Kesehatan IKIFA

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Abstract

Hypertension is one of the leading causes of maternal and fetal mortality and has more serious repercussions during childbirth. The three foremost causes of maternal mortality in obstetrics are hemorrhages (45%), infection (15%), and preeclampsia (13%). In pregnancy, hypertension is referred to as systolic blood pressure above 140 mmHg or diastolic blood pressure higher over 90 mmHg. Due to the risk of teratogenic effects of medication and mother physiologic changes in response to pregnancy, treatment during pregnancy requires special consideration. Methyldopa and Nifedipine are antihypertensive medications that can be performed during pregnancy. Antihypertensive therapy in pregnancy should be determined based on the pregnant patient's age, the class of antihypertensive drugs, single medications, and antihypertensive therapy combinations. As stated by results of this study, more pregnant women had hypertension between the ages of 26 and 30. When compared to other antihypertensive groups, nifedipine plus calcium blockers (CCB) is the safest and most effective type of antihypertensive therapy for pregnant women. Furthermore, some patients with hypertension in pregnancy require a combination of therapies to meet blood pressure targets; the use of a combination of nifedipine and methyldopa has been shown to overcome hypertension in pregnancy.
Phytochemical Screening and Total Flavonoid Content of Annona squamosa and Centella asiatica Ethanolic Extracts for Diabetic Wound Patch Junaedi Junaedi; Yetri Elisya; Ulya Syafrina
Jurnal Riset Kefarmasian Indonesia Vol. 8 No. 2 (2026): Jurnal Riset Kefarmasian Indonesia
Publisher : APDFI (Asosiasi Pendidikan Diploma Farmasi Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33759/jrki.v8i2.967

Abstract

Diabetic wounds are one of the chronic complications of diabetes mellitus, characterized by delayed healing and a high risk of bacterial infection. The development of natural product-based pharmaceutical preparations is considered a promising alternative approach due to their relative safety and wide availability. Soursop leaves (Annona squamosa L.) and gotu kola leaves (Centella asiatica L.) are known to contain various secondary metabolites that contribute to antibacterial activity and wound healing. This study aimed to perform phytochemical screening and determine the total flavonoid content of ethanolic extracts of soursop leaves and gotu kola leaves as a scientific basis for the development of an antibacterial patch for diabetic wound management. Extraction was conducted using maceration with 96% ethanol. Qualitative phytochemical screening was performed to identify flavonoids, phenolics, tannins, saponins, steroids, and alkaloids. Total flavonoid content was determined using UV–Vis spectrophotometry with quercetin as the reference standard at a maximum wavelength of 427 nm. The results showed that the extraction yields of soursop leaf and gotu kola leaf ethanolic extracts were 14.64% and 14.72%, respectively. Both extracts contained flavonoids, phenolics, tannins, steroids, and alkaloids, while saponins were detected only in the gotu kola leaf extract. The total flavonoid contents of soursop leaf and gotu kola leaf extracts were 1.5% and 1.12%, respectively. In conclusion, ethanolic extracts of soursop leaves and gotu kola leaves possess phytochemical profiles that support antibacterial and wound-healing activities, indicating their potential as active ingredients in antibacterial patch formulations for diabetic wounds.
Co-Authors Dwi Yunita Rizki Fajarsari Junaedi Junaedi Nanang Kurnia Achmadi Ulya Syafrina