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All Journal Indonesian Pharmacopeia Journal (IPJ)
Mohammad Rofiq Usman
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Chemistry Health Professions Medicine & Pharmacology

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The Anti-inflammatory effectiveness of a combination of basil leaf extract (Ocimum americanum L) and turmeric rhizome (Curcuma domestica Val) in mice with carrageenan induction kamalia dafira Dafira; Mohammad Rofiq Usman; Sholihatil Hidayati
Indonesian Pharmacopeia Journal Vol. 1 No. 2 (2024): July
Publisher : LPPM Universitas dr. Soebandi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36858/ipj.v1i2.17

Abstract

Background : Inflammation is the body's response to tissue injury, usuallycaused by physical trauma, damaging chemicals or microbiological agents.Basil leaves and turmeric rhizomes have been shown to be effective as antiinflammatories. The combination of these plants aims to determine the effectivedose as an anti-inflammatory.Objective: To determine the anti-inflammatory effectiveness of a combinationof basil leaf extract (Ocimum americanum L) and turmeric rhizome (Curcumadomestica Val) in rats with carrageenan induction.Method: This study is an experimental laboratory study using 28 male white ratsof the Wistar strain induced by 1% carrageenan. KN using CMC Na, KP sodiumdiclofenac, EK dose of 10 mg/KgBW, RK extract dose of 600 mg/KgBW andEKRK dose composition (2.5: 450 mg/KgBW, 5: 300 mg/KgBW, and 7.5: 150mg/KgB B ) . Continued with anti-inflammatory power. then data analysis usingSPSS version 26 began with a normality test and a homogeneity test as arequirement for the one-way ANOVA test.Results: The percentage results of anti-inflammatory power of KP 28.71%, EK10 mg/KgBB 33.00%, RK 600 mg/KgBB 33.23%, and EKRK 2.5: 450 mg/KgBB,5: 300 mg/KgBB, dose 7.5: 150 mg/KgBB respectively, namely 31.21%,28.65%, and 28.35% . The data obtained were continued with statistical testsusing SPSS version 26. The results of statistical tests using normality andhomogeneity tests were P> 0.05 and the one-way ANOVA test value was P>0.05.Conclusion: It can be concluded that the results of this study showed that in alltreatment groups it was proven effective as an anti-inflammatory. So it is hopedthat this study can be used as a reference for further research.
In Silico Analysis of Active Compounds in Brotowali (Tinospora crispa) as Antihyperglycemic Agents against α-Amylase Receptors Mohammad Rofiq Usman; Ishrolana Lutfi Anggraeni; Caca Engellina; Imelda Eka Fitriananda; Wan Faizah; Faradibah Andarista
Indonesian Pharmacopeia Journal Vol. 2 No. 2 (2025): 31 July 2025
Publisher : LPPM Universitas dr. Soebandi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36858/ipj.v2i2.58

Abstract

Hyperglycemia is a condition characterized by higher than normal blood sugar levels and is the main sign of diabetes mellitus. According to the International Diabetes Federation (IDF) in 2021, Indonesia ranks fifth with 19.47 million diabetics and a population of 179.72 million, and this makes the prevalence of diabetes in Indonesia 10.6%. One of the plants that is widely used as traditional medicine to reduce blood sugar levels is the brotowali plant (Tinospora crispa). This study aims to analyze the mechanism of active compounds of the brotowali plant (Tinospora crispa) that can inhibit the α-amylase enzyme through molecular tethering in silico. This study uses the method of tethering to receptors obtained from the PDB database (ID 1OSE). The positive control used was acarbose so as to obtain a new antihyperglycemic drug candidate with a good pharmacokinetic profile. The molecular tethering simulation results showed that the DL-Carnitine compound has the lowest ΔG value of -4.32 kcal/mol with a Ki value of 680.33 µM and a hydrophobic bond that plays an active role with the natural ligand ASP A:197. In terms of pharmacokinetics, the DL-carnitine compound is better than acarbose. It can be concluded that the DL-Carnitine compound is predicted to be carried out further as research as an antihyperglycemic candidate through α-amylase inhibition.
Co-Authors Caca Engellina Faradibah Andarista Imelda Eka Fitriananda Ishrolana Lutfi Anggraeni kamalia dafira Dafira Sholihatil Hidayati Wan Faizah