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All Journal Indonesian Pharmacopeia Journal (IPJ)
Iski Weni Pebriarti
Universitas dr Soebandi
Chemistry Health Professions Medicine & Pharmacology

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An OVERVIEW OF ANTIHYPERTENSION MEDICATION USE IN HYPERTENSION PATIENTS IN THE OUTPATIENT UNIT BALADHKA HUSADA HOSPITAL Shyntia Aurelia Fajratul Hikmah; Iski Weni Pebriarti; Jamhariyah
Indonesian Pharmacopeia Journal Vol. 2 No. 1 (2025): January 2025
Publisher : LPPM Universitas dr. Soebandi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36858/ipj.v2i1.40

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ABSTRACT Background: Hypertension is one of the cardiovascular diseases characterized by systolic blood pressure >140 mmHg and diastolic blood pressure >90 mmHg. This condition poses the highest risk as the leading cause of death due to cardiovascular diseases in Indonesia. According to Riskesdas data in 2018, the prevalence of hypertension in Indonesia reached 34.1%, an increase compared to Riskesdas 2013 at 25.8%. The management of hypertension can be conducted through pharmacological and non-pharmacological therapies. Pharmacological therapy involves the use of various classes of antihypertensive drugs tailored to each patient's clinical condition. Objective: This study aims to analyze the use of antihypertensive drugs based on the type of therapy, drug class, drug name, and the doses prescribed to hypertension patients in the outpatient unit of Baladhika Husada Hospital. Method: The samples for this study were collected using a simple random sampling technique. Results: The study conducted at Baladhika Husada Hospital in Jember during the period from September to November 2023, involving a total of 77 patient samples, showed that the most commonly used therapy was a combination of three drugs, found in 53 prescriptions (68.83%). The most commonly used drugs belonged to the beta-blocker class, specifically bisoprolol at a dose of 2.5 mg. Conclusion:The most dominant therapy for hypertension involves the combination of three drugs. The most frequently prescribed drug class is beta-blockers, with bisoprolol at a dose of 2.5 mg being the most widely used drug. Keywords: antihypertensive; hospital; hypertension; outpatient
Literature Review: Pharmacological Activity and Characteristics of Red Onion (Allium cepa L.) Arista Wahyuningsih; Shinta Mayasari; Iski Weni Pebriarti; Sepbrilla Ananda Kusriadi
Indonesian Pharmacopeia Journal Vol. 2 No. 2 (2025): 31 July 2025
Publisher : LPPM Universitas dr. Soebandi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36858/ipj.v2i2.54

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Shallot skin (Allium cepa L.) is a household waste that is still rarely utilized, even though it contains secondary metabolites such as flavonoids, anthocyanins, saponins, tannins, and other phenolic compounds that have pharmacological potential, especially as antioxidants and antibacterials. This study evaluates shallot skin's specific and non-specific pharmacognosy parameters through literature studies. Specific parameters include organoleptic, microscopic tests, and identifying active compound content using TLC, while non-specific parameters include water, ash, and contamination. The literature search method was done through Google Scholar, PubMed, and ScienceDirect, using the criteria of articles from 2015 to 2025. The study results indicate that flavonoid content, especially quercetin, contributes significantly to the antioxidant and anti-inflammatory effects. Shallot skin also shows effective antibacterial and antimicrobial activity against pathogenic strains such as Staphylococcus aureus, Escherichia coli, and Salmonella typhi. In addition, the mechanism of inhibition of α-amylase and α-glucosidase enzymes shows potential as an antidiabetic agent. Anticancer activity is supported by the active compounds' ability to induce apoptosis and inhibit cancer cell proliferation. With its abundant bioactive compound profile, shallot skin has the potential to be developed.
Co-Authors Arista Wahyuningsih Jamhariyah Sepbrilla Ananda Kusriadi Shyntia Aurelia Fajratul Hikmah