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All Journal Indonesian Journal of Chemistry AL-ULUM: JURNAL SAINS DAN TEKNOLOGI
Anita Apriliana
Sekolah Tinggi Ilmu Kesehatan Samarinda, Indonesia.
Agriculture, Biological Sciences & Forestry Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Decision Sciences, Operations Research & Management Energy

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Phytochemical Analysis and Anti-Thrombocytopenic Activity of Dayak Onion (Eleutherine palmifolia (L.) Merr) Extract and Fractions with HR-LCMS Profiling of Active Compounds Apriliana, Anita; Milanda, Tiana; Susilawati, Yasmiwar; Wilar, Gofarana
Indonesian Journal of Chemistry Vol 26, No 1 (2026)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijc.104534

Abstract

Thrombocytopenia, characterized by a low platelet count, poses significant clinical challenges and can arise from various etiologies. This study investigates the anti-thrombocytopenic effects of Dayak onion (Eleutherine palmifolia (L.) Merr) extracts and their fractions in Wistar rats. Ethanolic extracts and fractions were evaluated for their efficacy in enhancing platelet production. Male Wistar rats were administered doses of 100, 200, and 300 mg/kg, and platelet counts were measured at 24, 48, and 72 h post-treatment. Results indicated that all doses of the ethanolic extract significantly increased platelet counts over time, with the ethyl acetate fraction demonstrating the highest efficacy at a dose of 24.087 mg/kg, achieving significant increases as early as 24 h post-administration. Phytochemical analysis revealed substantial levels of phenolics (318.80 mg GAE/g) and flavonoids (45.63 mg QE/g) in the ethyl acetate fraction, with quercetin identified as a prominent compound via HR-LCMS. These findings suggest that Dayak onion possesses promising anti-thrombocytopenic properties, warranting further exploration as a therapeutic agent for accelerating platelet recovery in conditions such as dengue fever.
ANTIDEPRESSANT ACTIVITY TEST OF RED BETEL LEAF ETHANOL EXTRACT (Piper crocatum) ON MALE WHITE MICE (Mus musculus) USING THE FORCED SWIM TEST METHOD Triswanto Sentat; Anita Apriliana; Siti Lili Rizki Sari; Novi Milasari; Ghina Adhila; Rizki Rahmadi Pratama; M. Hasan Andryanto
AL-ULUM: JURNAL SAINS DAN TEKNOLOGI Vol 11 No 2 (2025)
Publisher : UPT Publication and Journal Management, Islamic University of Kalimantan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31602/jst.v11i2.18542

Abstract

Red betel leaves (Piper crocatum) contain flavonoids, alkaloids, polyphenols, tannins, and which is known for its antidepressant properties. The purpose of this study was to determine the effect of antidepressant activity of ethanol extract of red betel leaves on male white mice (Mus musculus) orally. The method used in testing antidepressants is the Forced Swim Test. Fifteen mice were divided into five groups: a positive control group receiving 3.5 mg/kg BW amitriptyline, a negative control group, and three groups receiving 200, 400, and 800 mg/kg BW of the extract. The antidepressant effect was measured by observing the immobility of mice during swimming. The results of the study using paired sample t-Test analysis showed that there was a difference in immobility before and after, in the 400 mg/kg BW extract and 3.5 mg/kg BW amitriptyline dose groups had significant differences.
Co-Authors Ghina Adhila Gofarana Wilar M. Hasan Andryanto Novi Milasari Rizki Rahmadi Pratama Siti Lili Rizki Sari TIANA MILANDA Triswanto Sentat Yasmiwar Susilawati