This study aims to analyze the influence of compensation and work motivation on employee performance at the Tambelang Community Health Center (Puskesmas), Bekasi Regency, using the Partial Least Squares Structural Equation Modeling (PLS-SEM) method. The study involves three variables: compensation, work motivation, and employee performance. Outer model testing results indicate that all indicators have outer loading values above 0.70, thereby confirming their validity. Reliability tests show Cronbach’s Alpha values ranging from 0.935 to 0.954 and Composite Reliability values above 0.90, while the Average Variance Extracted (AVE) exceeds 0.60, demonstrating that the research constructs are both valid and reliable. Discriminant validity tests using the Fornell-Larcker Criterion and HTMT also confirm that each construct possesses good discriminant validity. An R-Square value of 0.751 indicates that compensation and work motivation explain 75.1% of the variation in employee performance. Hypothesis testing reveals that compensation has a positive and significant effect on employee performance (β = 0.149; p = 0.049), whereas work motivation exerts a more dominant positive influence (β = 0.769; p < 0.001). The results demonstrate that enhancing work motivation and implementing a fair compensation system play a crucial role in improving employee performance. These findings are expected to serve as a basis for human resource management within healthcare facilities.