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All Journal JDS (Journal of Syiah Kuala Dentistry Society) SDJ
Priska Natassya
Departemen Biologi Oral, Fakultas Kedokteran Gigi, Universitas Trisakti, Indonesia
Dentistry Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Public Health

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Antibacterial and Antibiofilm Activity of Amoxicillin and Citrus sinensis Extract Against A. actinomycetemcomitans: Antibacterial and Antibiofilm Activity of Amoxicillin and Citrus sinensis Alexander Jonathan Nyomanto; Priska Natassya; Sheila Soesanto
Journal of Syiah Kuala Dentistry Society Vol. 10 No. 2 (2025): Vol 10 No. 2 2025
Publisher : Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24815/jds.v10i2.864

Abstract

Aggregatibacter actinomycetemcomitans is a major bacterial pathogen causing localized aggressive periodontitis, where its ability to form biofilms increases resistance to antibiotic therapies. Amoxicillin is commonly used as a treatment; however, prolonged use may lead to bacterial resistance. Alternative natural treatments with antibacterial and antibiofilm activities, such as the ethanol extract of Citrus sinensis peel, which is rich in flavonoids and saponins with bioactive potential, are needed. To investigate the antibacterial and antibiofilm effects of combining amoxicillin with the ethanol extract of C. sinensis peel against A. actinomycetemcomitans. This laboratory study was conducted in vitro using a post-test-only control-group design. Antibacterial testing was carried out using the plate count method, and antibiofilm testing was performed using the microtiter plate biofilm assay. The tested samples included amoxicillin (½ MBC) combined with the ethanol extract of C. sinensis peel at concentrations of 100%, 50%, 25%, 12.5%, 6.25%, and 3.125%, along with aquadest as the negative control and amoxicillin as the positive control. All concentrations of C. sinensis peel extract exhibited antibacterial effects against A. actinomycetemcomitans. The antibiofilm effect against A. actinomycetemcomitans was observed at 1 and 3 hours for extract concentrations of 3.125%, 6.25%, and 12.5%, with the 100% extract group demonstrating significant antibiofilm activity at all incubation times (1, 3, and 24 hours). At 24 hours, during the biofilm maturation phase, biofilms were less resistant, with antibiofilm effects observed at extract concentrations of 3.125%, 6.25%, and 12.5%, as well as in the 100% extract group. Conclusion: The combination of amoxicillin and the ethanol extract of C. sinensis peel has antibacterial and antibiofilm effects against A. actinomycetemcomitans
Is Herbal Mouthwash as Effective as Chlorhexidine?: A Review Sheila Soesanto; Jessica Endriyana; Priska Natassya
Scientific Dental Journal Vol. 7 No. 3 (2023): Sep-Dec
Publisher : Faculty of Dentistry, Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25105/sdj.v7i3.19352

Abstract

Pathogenic biofilms contribute to several oral problems, including caries, periodontitis, and other infections. Chlorhexidine has long been considered the gold standard for chemical dental plaque control. However, it is accompanied by adverse effects, such as taste alterations, staining, and cytotoxicity. In response to these challenges, herbal mouthwashes have emerged as a promising alternative treatment, with fewer drawbacks. The primary aim of this review was to assess the effectiveness of herbal mouthwashes in comparison to chlorhexidine. Adhering to the PRISMA guidelines, this review focused on questions concerning the effectiveness of herbal mouthwashes compared to chlorhexidine. A systematic search was executed in prominent databases, including PubMed, SpringerLink, ScienceDirect, and Wiley. Using predefined keywords, five articles were selected for inclusion in the review and subsequent research synthesis. The review findings suggest that herbal mouthwashes exhibit effectiveness comparable to chlorhexidine, accompanied by the added benefit of fewer side effects. However, further research is needed to comprehensively evaluate the long-term safety and efficacy of herbal mouthwash.
Co-Authors Alexander Jonathan Nyomanto Jessica Endriyana Sheila Soesanto Sheila Soesanto