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All Journal Sonde (Sound of Dentistry) SDJ
Jessica Endriyana
Departemen Biologi Oral, Fakultas Kedokteran Gigi, Universitas Trisakti, Indonesia
Dentistry

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Exploring IL-1β and IL-17 in Periodontitis-Associated Oral Aging Pathways Ria Aryani Hayuningtyas; Sheila Soesanto; Jessica Endriyana
SONDE (Sound of Dentistry) Vol. 9 No. 2 (2024): SONDE (Sound of Dentistry)
Publisher : Maranatha Christian University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.28932/sod.v9i2.11446

Abstract

Introduction: Periodontitis, a severe stage of periodontal disease marked by chronic and irreversible inflammation, is linked to a complex cytokine network. This persistent inflammation leads to significant genomic damage and the emergence of senescent phenotypes in oral tissues. This study aims to explore the role of interleukin-1β (IL-1β) and interleukin-17 (IL-17) in inducing oral senescence associated with periodontitis, particularly focusing on their contribution to the Senescence-Associated Secretory Phenotype (SASP). Methods: A thorough literature review was conducted via the MEDLINE database on PubMed, covering records up to 2018. Studies involving periodontitis patients formed the experimental group, while those on individuals with healthy periodontal conditions were the controls. Relevant in vitro studies on SASP were also included. Results and discussion: The results showed a significant increase in IL-1β and IL-17 secretion in periodontitis patients compared to those with healthy tissues. In vitro studies confirmed that these cytokines directly induce the secretion of SASP components, including SA‑β‑gal, p21, p53, plasminogen activator inhibitor-1 (PAI-1), and p16. These findings suggest that IL-1β and IL-17 play a critical role in promoting cellular senescence in periodontal tissues by inducing SASP. Conclusion: This study highlights IL-1β and IL-17 as key mediators in oral senescence within the context of periodontitis. Their excessive production contributes to SASP, leading to cellular senescence in periodontal tissues. Understanding these mechanisms is crucial for developing targeted therapies to mitigate the detrimental effects of chronic periodontitis on oral health.
Is Herbal Mouthwash as Effective as Chlorhexidine?: A Review Sheila Soesanto; Jessica Endriyana; Priska Natassya
Scientific Dental Journal Vol. 7 No. 3 (2023): Sep-Dec
Publisher : Faculty of Dentistry, Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25105/sdj.v7i3.19352

Abstract

Pathogenic biofilms contribute to several oral problems, including caries, periodontitis, and other infections. Chlorhexidine has long been considered the gold standard for chemical dental plaque control. However, it is accompanied by adverse effects, such as taste alterations, staining, and cytotoxicity. In response to these challenges, herbal mouthwashes have emerged as a promising alternative treatment, with fewer drawbacks. The primary aim of this review was to assess the effectiveness of herbal mouthwashes in comparison to chlorhexidine. Adhering to the PRISMA guidelines, this review focused on questions concerning the effectiveness of herbal mouthwashes compared to chlorhexidine. A systematic search was executed in prominent databases, including PubMed, SpringerLink, ScienceDirect, and Wiley. Using predefined keywords, five articles were selected for inclusion in the review and subsequent research synthesis. The review findings suggest that herbal mouthwashes exhibit effectiveness comparable to chlorhexidine, accompanied by the added benefit of fewer side effects. However, further research is needed to comprehensively evaluate the long-term safety and efficacy of herbal mouthwash.
Co-Authors Priska Natassya Ria Aryani Hayuningtyas Sheila Soesanto Sheila Soesanto