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All Journal Sustainable in Energy Science and Technology
Inten Pangestika
Industrial Chemical Engineering Technology, Department of Mechanical Engineering, Politeknik Negeri Medan, 20155, Medan, Indonesia
Chemical Engineering, Chemistry & Bioengineering Chemistry Energy Engineering Industrial & Manufacturing Engineering Materials Science & Nanotechnology Mechanical Engineering Physics

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Literature Review: Computational Methods for Designing Thermostable, Efficient, and Cost-Effective Enzymes for Industrial Applications Prisca Caesa Moneteringtyas; Nahzim Rahmat; Inten Pangestika; Sri Rahayu Widya Ningrum; Annisa Fillaeli; Aliyah Aliyah
Sustainable in Energy Science and Technology Vol. 1 No. 1 (2025): Sustainable in Energy and Science Technology
Publisher : Politeknik Negeri Medan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51510/siest.v1i1.2578

Abstract

Enzymes play a vital role as biocatalysts in various industrial applications due to their high specificity and efficiency under mild conditions. However, their limited thermostability significantly constrains their operational lifespan and effectiveness at elevated temperatures. This review examines recent advancements in computational methods aimed at enhancing enzyme thermostability, focusing on structure-based rational design, machine learning, and hybrid approaches. Key findings highlight the effectiveness of structure-based methods, in optimizing enzyme structures, while machine learning approaches demonstrated potential in predicting stabilizing mutations. This review identifies key research gaps and proposes directions for future studies to facilitate the industrial adoption of thermostable enzymes.
Co-Authors Aliyah Aliyah Annisa Fillaeli Nahzim Rahmat Prisca Caesa Moneteringtyas Sri Rahayu Widya Ningrum