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All Journal Journal of Innovative and Creativity Pharmacon: Jurnal Farmasi Indonesia
Khairunnisa Khairunnisa
Universitas Muhammadiyah Kalimantan Timur
Education Health Professions Languange, Linguistic, Communication & Media Mathematics Medicine & Pharmacology Social Sciences Other

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Literatur Rivew: Pengaruh Sayur-Sayuran Pada Ibu Hamil Dengan Kondisi Anemia M. Bachtiar Safrudin; Dwi Widyiastuti; Khairunnisa Khairunnisa; Fika Veny Hapsari; Vika Yulianita; Risa Putri Amalia; Khofifah Yuniarsih Sadri; Puja Magvirah; Anisah Aulia Salsabila; Salzabila Ulfa Luthfiyanti; Titha Endriyana; Valentino Ardana Dumat; Ferdi Rahmadani
Journal of Innovative and Creativity Vol. 5 No. 2 (2025)
Publisher : Fakultas Ilmu Pendidikan Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/joecy.v5i2.743

Abstract

Anemia pada ibu hamil merupakan masalah kesehatan yang berdampak pada ibu dan janin, terutama di negara berkembang. Salah satu upaya non-farmakologis dalam pencegahan dan penanganan anemia adalah melalui konsumsi sayur-sayuran kaya zat besi, seperti bayam, daun kelor, dan kacang hijau. Penelitian ini bertujuan untuk menganalisis efektivitas konsumsi sayur-sayuran dalam meningkatkan kadar hemoglobin ibu hamil yang mengalami anemia, serta mengeksplorasi inovasi produk pangan berbasis sayuran sebagai alternatif solusi. Penelitian ini dilakukan dengan metode kajian pustaka (literature review) terhadap jurnal nasional dan internasional yang terbit dalam sepuluh tahun terakhir. Artikel yang dikaji membahas efektivitas konsumsi sayuran dalam meningkatkan kadar hemoglobin serta inovasi produk berbasis sayuran yang dapat diterapkan sebagai intervensi dalam pencegahan dan penanganan anemia pada ibu hamil. Analisis dilakukan dengan membandingkan hasil penelitian terkait konsumsi sayuran, pola diet ibu hamil, serta faktor yang memengaruhi keberhasilan intervensi. Analisis terhadap jurnal-jurnal yang dikumpulkan menunjukkan adanya pengaruh  sayur-sayuran pada ibu hamil dengan kondisi anemia.
In Silico Analysis of Momordica charantia L. as Antidiabetic Agents of GSK-3β Receptors and It's Antioxidant Activity Asri Dwi Endah Dewi Pramesthi; Khairunnisa Khairunnisa; Aurelia Nabilla Zuliet; Melani Pebriana Putri; Paula Mariana Kustiawan
Pharmacon: Jurnal Farmasi Indonesia Vol. 22 No. 2 (2025)
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/pharmacon.v22i2.13447

Abstract

Diabetes mellitus is included in the group of degenerative diseases with the highest incidence rate globally. This study was conducted to evaluate the potential of bioactive compounds contained in bitter melon (Momordica charantia L.) as antidiabetic and antioxidant agents using an in silico approach. The methods used include molecular docking simulations, pharmacokinetic and toxicological  analyses were carried out using Absorption, Distribution, Metabolism, Excretion, and Toxicology parameters as well as drug suitability tests based on the Lipinski rule of five. The test results showed that bitter melon juice obtained an IC50 of 63.18 μg/ml while vitamin C as a comparison obtained an IC50 of 7.60 μg/ml. The docking results show that the Kaemferol compound has the highest binding affinity (-6.64 Kcal/mol), Quercetin (-6.28 Kcal/mol) and Charantoside I (6.07 Kcal/mol) have stable binding energy, the interaction of charantin, quercetin, kaemferol and charantoside I residues is similar to native ligands such as Valine 135, Cysteine 199, Valine 70 and Lysine 85. Based on the ADMET profile results, the quercetin and kaemferol compounds have high absorption, Caco-2 permeability which supports oral bioavailability, and do not show the ability to penetrate the blood-brain barrier, which indicates safety for the central nervous system, as well as low AMES toxicity and hepatotoxicity. As the conclusion, kaempferol and quercetin compounds have  the potential as GSK-3β inhibitors. Antioxidant activity of bitter melon juice and vitamin C are categorized as strong. Further  research regarding the mechanism of action of Momordica charantia L. as an alternative therapeutic agent in the management of type  2 diabetes is needed. 
Co-Authors Anisah Aulia Salsabila Asri Dwi Endah Dewi Pramesthi Aurelia Nabilla Zuliet Dwi Widyiastuti Ferdi Rahmadani Fika Veny Hapsari Khofifah Yuniarsih Sadri M. Bachtiar Safrudin Melani Pebriana Putri Paula Mariana Kustiawan Puja Magvirah Risa Putri Amalia Salzabila Ulfa Luthfiyanti Titha Endriyana Valentino Ardana Dumat Vika Yulianita