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Nerly Juli Pranita Simanjuntak
Department of Clinical Pharmacy, Faculty of Health Sciences, Universitas Prima Indonesia, Medan, 20118, Indomesia
Education Languange, Linguistic, Communication & Media Mathematics Social Sciences Other

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ISOLASI METABOLIT SEKUNDER MENGGUNAKAN KROMATOGRAFI LAPIS TIPIS (KLT) DAN PENGUKURAN AKTIVITAS ANTIOKSIDAN DENGAN METODE DPPH PADA DAUN KOPASANDA (Chromolaena odorata L) Riris Pardede; Nerly Juli Pranita Simanjuntak; Novitaria Br Sembiring
Journal of Innovative and Creativity Vol. 6 No. 1 (2026)
Publisher : Fakultas Ilmu Pendidikan Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/joecy.v6i1.7097

Abstract

Radikal bebas menyebabkan stres oksidatif yang memicu penyakit degeneratif, sehingga antioksidan alami dari tanaman seperti kopasanda (Chromolaena odorata L.) semakin dibutuhkan mengingat risiko efek samping antioksidan sintetis. Penelitian ini bertujuan menganalisis metabolit sekunder daun kopasanda melalui isolasi KLT dan mengukur aktivitas antioksidannya dengan metode DPPH. Penelitian eksperimental kuantitatif ini menggunakan sampel 3 kg daun segar dari perkebunan karet Tarutung Panjang, Mandailing Natal, Sumatera Utara, diekstrak etanol 96%. Instrumen meliputi rotary evaporator, spektofotometer UV-Vis, dan plat KLT; analisis data mencakup skrining fitokimia, pengukuran Rf, serta regresi linier IC50. Hasil menunjukkan alkaloid, flavonoid, tanin, dan terpenoid/steroid terdeteksi (Rf 0,2-0,86), saponin negatif fitokimia. Ekstrak etanol memiliki IC50 0,003833 ppm (sangat kuat), lebih baik dari vitamin C (0,4654 ppm), dengan r² 0,9444. Daun kopasanda berpotensi sebagai antioksidan alami unggul untuk suplemen dan pangan fungsional.
PENENTUAN KADAR FENOL TOTAL DAN UJI AKTIVITAS ANTIOKSIDAN KOMBINASI EKSTRAK ETANOL DAUN MINT (MENTHA PIPERITA L.) DAN DAUN KEMANGI (OCIMI BASILICI F. CITRATI FOLIUM) DENGAN METODE DPPH Olidermawanto Telaumbanua; Nerly Juli Pranita Simanjuntak; Erida Novriani
Journal of Innovative and Creativity Vol. 6 No. 1 (2026)
Publisher : Fakultas Ilmu Pendidikan Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/joecy.v6i1.7175

Abstract

Amid the rising incidence of degenerative diseases due to oxidative stress in Indonesia, natural antioxidants from mint leaves (Mentha piperita L.) and basil (Ocimum basilicum f. citrati) have potential as an alternative. This laboratory quantitative experimental study aimed to determine the total phenolic content and antioxidant activity of a 1:1 ethanol extract combination using the Folin-Ciocalteu and DPPH methods. The population was fresh leaves from Medan, with 1 kg of dried simplicia samples each selected purposively. Instruments used included a UV-Vis spectrophotometer (730 nm for phenolics, 517 nm for DPPH), linear regression analysis of the calibration curve (R²=0.965), and triplicate IC50 data. Results showed a total phenolic content of 19.16 ± 1.08 mg GAE/g and very strong antioxidant activity (IC50 9.891 µg/mL), exceeding the 50 µg/mL threshold though lower than vitamin C (4.852 µg/mL), confirming phenolic synergy. In conclusion, the combination has high potential as an anti-degenerative phytopharmaceutical.
Co-Authors Erida Novriani Novitaria Br Sembiring Olidermawanto Telaumbanua Riris Pardede