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Pina Hoerunisa
Universitas Bakti Tunas Husada Tasikmalaya
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Tinjauan Kimia Medisinal Terhadap Senyawa Nefrotoksik Dalam Makanan: Mekanisme Kerusakan Ginjal dan Implikasinya Terhadap Kesehatan Masyarakat Saeful Amin; Anjar Juliyana; Dea Puspita; Pina Hoerunisa; Rafly Fadillah Darusman; Shifa Nurafifah
Jurnal Ners Vol. 9 No. 2 (2025): APRIL 2025
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jn.v9i2.44227

Abstract

Paparan terhadap senyawa-senyawa nefrotoksik dalam berbagai jenis produk pangan telah menjadi isu penting dalam bidang kesehatan masyarakat, mengingat peran vital ginjal dalam menjaga homeostasis tubuh. Sejumlah zat berpotensi toksik seperti logam berat (misalnya kadmium, timbal, dan merkuri), aditif makanan sintetis (seperti pemanis buatan dan pewarna kimia), serta kontaminan hasil proses termal seperti akrilamida dan heterosiklik amina, diketahui dapat menimbulkan kerusakan struktural dan fungsional pada jaringan ginjal secara kumulatif. Tujuan penelitian untuk memperluas wawasan terkait keberadaan senyawa nefrotoksik dalam makanan, mekanisme kerusakan ginjal yang ditimbulkannya, serta implikasi terhadap kesehatan masyarakat secara menyeluruh, khususnya dari pendekatan kimia medisinal. Hasil keberadaan senyawa nefrotoksik dalam bahan pangan merupakan ancaman yang signifikan bagi kesehatan ginjal, organ penting yang berperan dalam detoksifikasi, pengaturan tekanan darah, serta menjaga keseimbangan cairan tubuh. Senyawa seperti mikotoksin (seperti OTA dan citrinin), logam berat (timbal, kadmium, dan uranium), asam aristolochic, serta bahan tambahan makanan seperti nitrat, nitrit, dan pemanis buatan memiliki potensi besar dalam memicu kerusakan ginjal melalui mekanisme biologis dan kimiawi yang kompleks. Diharapkan, hasil kajian ini dapat menjadi kontribusi ilmiah dalam merumuskan strategi mitigasi risiko serta meningkatkan kesadaran publik terhadap pentingnya keamanan pangan dalam menjaga kesehatan ginjal jangka panjang.
Penerapan Prinsip 3R dalam Pengelolaan Sampah Rumah Tangga pada Masyarakat Desa Sukaratu Yoga Sugama; Saeful Amin; Anisa Pebiansyah; Nabila Amelia; Pina Hoerunisa; Tiwi Nuraeni; Fitria Yustyanti; Rohmah Aisyah
Jurnal Insan Pengabdian Indonesia Vol. 4 No. 3 (2026): September : Jurnal Insan Pengabdian Indonesia
Publisher : PT. ALHAFI BERKAH INDONESIA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62007/jouipi.v4i3.1014

Abstract

Household waste management remains an environmental issue, including in Sukaratu Village, where waste is still commonly mixed at the source. This activity aimed to improve community understanding of waste management based on the principles of Reduce, Reuse, and Recycle (3R) and to evaluate changes in understanding after education. The activity was conducted on August 4, 2026, at Sukaratu Village Hall using a descriptive approach involving socialization, discussion, and evaluation through a closed questionnaire consisting of nine questions. Fourteen participants attended the activity and completed both the pretest and posttest. Data were analyzed descriptively and using the Wilcoxon Signed-Rank Test because one data group was not normally distributed. The results showed that the average understanding score increased from 70.1% in the pretest to 92.9% in the posttest, representing an increase of 22.8 percentage points. All participants (100%) experienced increased scores, and the Wilcoxon test indicated a significant difference between the pretest and posttest (p = 0.001). These findings suggest that socialization and discussion can improve understanding of 3R principles, particularly waste reduction, reuse, and segregation. However, further support is needed to ensure sustained behavioral changes and implementation in daily life.
Co-Authors Anisa Pebiansyah Anjar Juliyana Dea Puspita Fitria Yustyanti Nabila Amelia Rafly Fadillah Darusman Rohmah Aisyah Saeful Amin Shifa Nurafifah Tiwi Nuraeni Yoga Sugama