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Sinta Chaira Maulanisa
University of Riau
Health Professions Medicine & Pharmacology Nursing

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Serum Prolactine Levels and Prolactine Receptor Expression in Premenopausal Breast Cancer: A Potential Predictive Biomarker? Effif Syofra Tripriadi; Sinta Chaira Maulanisa; Nur Indrawati Lipoeto; Yanwirasti Yanwirasti; Fadil Oenzil; Wirsma Arif Harahap; Tania Nugrah Utami; Farah Mardhiyah
Jurnal Ners Vol. 10 No. 1 (2026): JANUARI 2026
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jn.v10i1.52299

Abstract

Introduction: Premenopausal breast cancer (PBC) is often more aggressive than postmenopausal cases, with prolactin playing a key role in tumor development. This study examines the relationship between serum prolactin levels, prolactin receptor (PRLR) expression, and clinicopathological features in PBC patients. Methods: This cross-sectional study was conducted from 2021 - 2022 at multiple hospitals in Pekanbaru, Indonesia. Thirty-five PBC patients and 35 healthy controls were included. Serum prolactin levels were measured using ELISA, and PRLR expression was assessed via IHC. Statistical analysis was performed using independent t-tests and correlation analysis (p < 0.05). Results: PBC patients had higher prolactin levels (51.96±80.40 ng/mL) than controls (20.83±15.74 ng/mL, p = 0.031). PRLR expression was detected in over 90% of tumors, with a significant correlation between prolactin levels and cancer stage (p = 0.035). Discussion: These findings suggest prolactin contributes to PBC progression, with higher levels linked to advanced stages, possibly through JAK2/STAT5 signaling. Conclusion: Serum prolactin levels and PRLR expression are associated with cancer stage, supporting their potential as biomarkers for early detection and disease progression. Further studies are needed for validation.
Total Colonic Tubular Duplication Associated With Anorectal Malformation: A Case Report and Surgical Reconstruction Approach Dhon Rizal Gusnanda; Ismar Ismar; Tubagus Odih Rhomdani Wahid; Khairuli Amri; Andrea Valentino; Sinta Chaira Maulanisa
Jurnal Ners Vol. 10 No. 1 (2026): JANUARI 2026
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jn.v10i1.52465

Abstract

Total colonic duplication is an exceptionally rare subtype of gastrointestinal duplication, often associated with anorectal malformations. Diagnostic difficulty arises from variable morphology, shared mesenteric structures, and inconsistent imaging findings. Early recognition remains limited, and many cases are identified only during operative exploration. A 10-month-old male with a history of anorectal malformation previously treated with colostomy underwent evaluation for definitive repair. Intraoperative assessment, including loop colonography, identified two parallel colonic lumens extending from cecum to rectum. Exploratory laparotomy confirmed complete tubular duplication with a shared mesentery. Reconstruction was achieved through a side-to-side window anastomosis using a stapling device, followed by creation of a protective ileostomy. Postoperative recovery was uneventful, with adequate stoma perfusion and preserved bowel function. The patient remained stable during follow-up and was scheduled for staged abdominoperineal anoplasty. Complete colonic duplication may not be detected preoperatively and frequently requires intraoperative confirmation. Preservation of vascular supply and staged reconstruction are central to optimizing outcomes.Individualized surgical planning and careful anatomical delineation support favorable early recovery and functional prognosis in total colonic duplication with anorectal malformation.
Co-Authors Andrea Valentino Dhon Rizal Gusnanda Effif Syofra Tripriadi Fadil Oenzil Farah Mardhiyah Ismar Ismar Khairuli Amri Nur Indrawati Lipoeto Tania Nugrah Utami Tubagus Odih Rhomdani Wahid Wirsma Arif Harahap Yanwirasti Yanwirasti