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Serum Prolactine Levels and Prolactine Receptor Expression in Premenopausal Breast Cancer: A Potential Predictive Biomarker? Effif Syofra Tripriadi; Sinta Chaira Maulanisa; Nur Indrawati Lipoeto; Yanwirasti Yanwirasti; Fadil Oenzil; Wirsma Arif Harahap; Tania Nugrah Utami; Farah Mardhiyah
Jurnal Ners Vol. 10 No. 1 (2026): JANUARI 2026
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jn.v10i1.52299

Abstract

Introduction: Premenopausal breast cancer (PBC) is often more aggressive than postmenopausal cases, with prolactin playing a key role in tumor development. This study examines the relationship between serum prolactin levels, prolactin receptor (PRLR) expression, and clinicopathological features in PBC patients. Methods: This cross-sectional study was conducted from 2021 - 2022 at multiple hospitals in Pekanbaru, Indonesia. Thirty-five PBC patients and 35 healthy controls were included. Serum prolactin levels were measured using ELISA, and PRLR expression was assessed via IHC. Statistical analysis was performed using independent t-tests and correlation analysis (p < 0.05). Results: PBC patients had higher prolactin levels (51.96±80.40 ng/mL) than controls (20.83±15.74 ng/mL, p = 0.031). PRLR expression was detected in over 90% of tumors, with a significant correlation between prolactin levels and cancer stage (p = 0.035). Discussion: These findings suggest prolactin contributes to PBC progression, with higher levels linked to advanced stages, possibly through JAK2/STAT5 signaling. Conclusion: Serum prolactin levels and PRLR expression are associated with cancer stage, supporting their potential as biomarkers for early detection and disease progression. Further studies are needed for validation.
Factors Associated With Family Caregivers’ Knowledge and Attitudes Toward Home-Based Geriatric Care in Primary Healthcare: A Cross-Sectional Study Savitri Gemini; Nur Indrawati Lipoeto; Rizanda Machmud; Arina Widya Murni
Majalah Kesehatan Indonesia Vol. 7 No. 3 (2026)
Publisher : Utan Kayu Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47679/makein.2026324

Abstract

Family caregivers play a central role in home-based geriatric care, especially in settings where institutional long-term care remains limited. However, caregiver capacity may vary according to socio-demographic, relational, and service-related factors. This study aimed to identify factors associated with family caregivers’ knowledge and attitudes toward home-based geriatric care in a primary healthcare context. A quantitative analytic study with a cross-sectional design was conducted from September to December 2025 in two Puskesmas working areas in Batam City, Indonesia. A total of 326 family caregivers were recruited using proportional sampling. Data were collected through structured questionnaires and analyzed using univariate analysis, Chi-square tests, and multivariate logistic regression. Most caregivers had low knowledge (86.5%) and negative attitudes (61.0%) despite reporting high communication patterns and positive perceptions of healthcare facility quality. Bivariate analysis showed that economic status, caregiving duration, communication pattern, and perceived quality of healthcare facilities were significantly associated with knowledge, whereas economic status, communication pattern, and perceived quality of healthcare facilities were associated with attitudes. In the multivariate model, only caregiving duration (AOR = 15.790; p < 0.001) and communication pattern (AOR = 0.157; p = 0.013) remained independently associated with caregiver knowledge. No independent predictors were identified for attitudes. These findings indicate that caregiver knowledge was more strongly associated with experiential and relational factors, particularly caregiving duration and family communication. Structured, family-centered, and nurse-led interventions in primary healthcare may help strengthen caregiver preparedness in home-based geriatric care. Abstrak: Caregiver keluarga memainkan peran sentral dalam perawatan geriatri berbasis rumah, terutama di lingkungan yang layanan perawatan jangka panjang institusionalnya masih terbatas. Namun, kapasitas caregiver dapat bervariasi menurut faktor sosiodemografis, relasional, dan faktor terkait layanan. Penelitian ini bertujuan untuk mengidentifikasi faktor-faktor yang berhubungan dengan pengetahuan dan sikap caregiver keluarga terhadap perawatan geriatri berbasis rumah dalam konteks pelayanan kesehatan primer. Penelitian kuantitatif analitik dengan desain potong lintang dilakukan dari September hingga Desember 2025 di dua wilayah kerja Puskesmas di Kota Batam, Indonesia. Sebanyak 326 caregiver keluarga direkrut menggunakan proportional sampling. Data dikumpulkan melalui kuesioner terstruktur dan dianalisis menggunakan analisis univariat, uji Chi-square, dan regresi logistik multivariat. Sebagian besar caregiver memiliki pengetahuan rendah (86,5%) dan sikap negatif (61,0%) meskipun melaporkan pola komunikasi yang tinggi dan persepsi positif terhadap kualitas fasilitas pelayanan kesehatan. Analisis bivariat menunjukkan bahwa status ekonomi, lama merawat, pola komunikasi, dan persepsi terhadap kualitas fasilitas pelayanan kesehatan berhubungan secara signifikan dengan pengetahuan, sedangkan status ekonomi, pola komunikasi, dan persepsi terhadap kualitas fasilitas pelayanan kesehatan berhubungan dengan sikap. Pada model multivariat, hanya lama merawat (AOR = 15,790; p < 0,001) dan pola komunikasi (AOR = 0,157; p = 0,013) yang tetap berhubungan secara independen dengan pengetahuan caregiver. Tidak ditemukan prediktor independen untuk sikap. Temuan ini menunjukkan bahwa pengetahuan caregiver lebih kuat berhubungan dengan faktor pengalaman dan relasional, khususnya lama merawat dan komunikasi keluarga. Intervensi yang terstruktur, berpusat pada keluarga, dan dipimpin oleh perawat di pelayanan kesehatan primer berpotensi membantu memperkuat kesiapan caregiver dalam perawatan geriatri berbasis rumah.