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CORRELATION OF C-REACTIVE PROTEIN (CRP), AND INTERLEUKIN-6 (IL-6) WITH HEPCIDIN LEVELS IN PATIENTS WITH ANEMIA OF CHRONIC DISEASE (ACD) I Putu Arya Giri Prebawa; Ketut Suega
Al-Iqra Medical Journal : Jurnal Berkala Ilmiah Kedokteran Vol 6, No 2 (2023): Al-Iqra Medical Journal: Jurnal Berkala Ilmiah Kedokteran
Publisher : Journal Medical Universitas muhammadiyah Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26618/aimj.v6i2.9984

Anemia of chronic disease (ACD) or anemia of chronic inflammation is the most common cause of anemia in hospitalized patients. Recent studies revealed that interleukin-6 (IL-6), C-reactive protein (CRP), and Hepcidin play a key role in ACD pathogenesis. This study is an observational study with a crossectional approach that aims to see the relationship between levels of inflammatory marker such as CRP and IL-6 with Hepcidin on the incidence of ACD at Prof Ngoerah Hospital Denpasar. This study involved 92 samples. Descriptive analysis will be presented in the form of tables and narratives for all data obtained in this study. Bivariate analysis was carried out using the Spearman correlation. The mean CRP level of the patients in this study was 89.1 ± 80.1 mg/L which could be categorized as high. The mean Il-6 level of the patients in this study was 91,8±88,4 pg/mL which could be categorized as high and the Hepcidin level in this study was 64.4 ± 49.9 ng/dL. This study shows that inflammation plays a role in increasing levels of Hepcidin which plays a role in the pathogenesis of ACD. This can be seen from the significant positive correlation between Hepcidin levels and IL-6 levels (P=0,00), although there is no correlation between Hepcidin and CRP. Inflammation plays a role in increasing levels of Hepsidin which plays a role in the pathogenesis of ACD

CORRELATION OF C-REACTIVE PROTEIN (CRP), AND INTERLEUKIN-6 (IL-6) WITH HEPCIDIN LEVELS IN PATIENTS WITH ANEMIA OF CHRONIC DISEASE (ACD) Giri Prebawa, I Putu Arya; Suega, Ketut
Al-Iqra Medical Journal : Jurnal Berkala Ilmiah Kedokteran Vol. 6 No. 2 (2023): Al-Iqra Medical Journal: Jurnal Berkala Ilmiah Kedokteran
Publisher : Journal Medical Universitas muhammadiyah Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26618/aimj.v6i2.9984

Anemia of chronic disease (ACD) or anemia of chronic inflammation is the most common cause of anemia in hospitalized patients. Recent studies revealed that interleukin-6 (IL-6), C-reactive protein (CRP), and Hepcidin play a key role in ACD pathogenesis. This study is an observational study with a crossectional approach that aims to see the relationship between levels of inflammatory marker such as CRP and IL-6 with Hepcidin on the incidence of ACD at Prof Ngoerah Hospital Denpasar. This study involved 92 samples. Descriptive analysis will be presented in the form of tables and narratives for all data obtained in this study. Bivariate analysis was carried out using the Spearman correlation. The mean CRP level of the patients in this study was 89.1 ± 80.1 mg/L which could be categorized as high. The mean Il-6 level of the patients in this study was 91,8±88,4 pg/mL which could be categorized as high and the Hepcidin level in this study was 64.4 ± 49.9 ng/dL. This study shows that inflammation plays a role in increasing levels of Hepcidin which plays a role in the pathogenesis of ACD. This can be seen from the significant positive correlation between Hepcidin levels and IL-6 levels (P=0,00), although there is no correlation between Hepcidin and CRP. Inflammation plays a role in increasing levels of Hepsidin which plays a role in the pathogenesis of ACD.

Transformasi Paradigma Ensefalopati Hepatikum: Integrasi Gut–Liver–Brain Axis, Neuroinflamasi, dan Biomarker Modern I Putu Arya Giri Prebawa
Jurnal Ners Vol. 10 No. 1 (2026): JANUARI 2026
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jn.v10i1.53474

Hepatic encephalopathy (HE) is increasingly recognized as a complex neuropsychiatric disorder driven by multidimensional interactions within the gut–liver–brain axis rather than ammonia toxicity alone. Recent evidence demonstrates that the synergy between hyperammonemia, systemic inflammation, microbiota dysbiosis, and metabolite dysregulation—particularly bile acids—triggers microglial activation, astrocytic dysfunction, and blood–brain barrier disruption. Sarcopenia and myosteatosis further impair ammonia detoxification and reduce neuroprotective signaling. Emerging biomarkers, including neurofilament light chain (NfL), YKL-40, bile-acid panels, and functional neuroimaging (rs-fMRI, DTI), provide improved sensitivity for early detection of subclinical impairment. Therapeutic strategies now extend beyond ammonia reduction to microbiota modulation (rifaximin, FMT), next-generation ammonia scavengers, and muscle-targeted interventions. Integration of metabolomic profiles with artificial intelligence supports the development of precision medicine approaches, enabling accurate risk stratification and personalized therapeutic planning. This article summarizes the evolving pathophysiological paradigm, diagnostic advances, and future therapeutic innovations in HE.

PKM Pelatihan Pertolongan Pertama pada Kecelakaan (P3K) pada Anggota PMR SMA Negeri di Denpasar Ni Wayan Sri Ekayanti; Putu Austin Widyasari Wijaya; I Putu Arya Giri Prebawa
Warmadewa Minesterium Medical Journal Vol. 4 No. 1 (2025): Januari 2025
Publisher : Warmadewa University Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22225/wmmj.4.1.2025.27-31

Abstrak Pelatihan pertolongan pertama pada kecelakaan mempunyai peranan yang sangat penting dalam menyiapkan kesiapsiagaan siswa dalam menghadapi keadaan atau situasi darurat terutama di lingkungan sekolah. Permasalahan prioritas yang ditangani adalah adanya anggota PMR yang belum mendapat pelatihan P3K pada tahun ajaran baru. Solusi yang diberikan berupa penyuluhan dan pelatihan P3K pada anggota PMR di SMA Negeri di Denpasar. Kegiatan ini bertujuan untuk meningkatkan pengetahuan dan keterampilan siswa dalam melakukan pertolongan pertama pada kecelakaan di sekolah. Metode yang digunanakan adalah penyuluhan dan Focus Group Discussion untuk mengefektifkan kegiatan dan meningkatkan pemahaman dan keterampilan siswa. Hasil menunjukkan terdapat peningkatan pengetahuan peserta sebesar 30% setelah mengikuti penyuluhan dan peningkatan keterampilan siswa mengenai tatalaksana dalam P3K. Kesimpulan dari kegiatan ini adalah meningkatnya pengetahuan dan keterampilan anggota PMR dalam P3K. Hal ini menunjukkan keberhasilan dan efektifitas program dalam meningkatkan pengetahuan dan keterampilan siswa dalam melakukan pertolongan pertama pada kecelakaan di sekolah. Kata kunci : P3K, kecelakaan, sekolah

Skrining Sarkopenia dan Gangguan Metabolik: Investasi Kesehatan Lansia Denpasar I Putu Arya Giri Prebawa; Ketut Wahyudiana Sudana; Ni Made Puspa Dewi Astawa
Warmadewa Minesterium Medical Journal Vol. 4 No. 2 (2025): Mei 2025
Publisher : Warmadewa University Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22225/wmmj.4.2.2025.164-170

The elderly population in Indonesia continues to increase significantly every year. Common health problems experienced by the elderly are decreased motor function, known as sarcopenia, and metabolic disorders. Sesetan Village in Denpasar is one of the areas with the highest elderly population. This high number of elderly poses special challenges in the areas of health and environment. As a solution, counseling and screening of metabolic disorders and sarcopenia were conducted for posyandu cadres and the elderly, along with socialization of household waste sorting. The targets of this activity were posyandu cadres and the elderly in the Banjar Dinas Taman Sari neighborhood. This activity includes coordination with the head of the neighborhood and coordinator of posyandu cadres, counseling, health screening, and socialization of household waste sorting. Partners in this program are posyandu cadres and the elderly in the Banjar Dinas Taman Sari Environment, Sesetan Village, South Denpasar District. The priority problems addressed were metabolic disorders and sarcopenia. The methods used include counseling, discussion, screening, and training. The program implementation began with a pretest to measure initial understanding, followed by counseling, training, discussion, and ended with a posttest. Health screening was carried out using blood sugar, cholesterol, and uric acid testing tools. The results of the activity showed an increase in knowledge of the elderly and family members about metabolic disorders and sarcopenia, obtained data related to the risk of metabolic disorders and sarcopenia in the elderly, and increased understanding and awareness of the importance of sorting household waste before disposal to landfills. Evaluation was carried out by asking posttest questions after the program implementation. This activity succeeded in motivating partners to take prevention and understand the importance of health in overcoming metabolic problems and sarcopenia in the elderly.

Update on the Diagnosis of Traveler’s Diarrhea: Current Strategies and Emerging Trends Kennedy Winata; Kartika Cahyaningrum; Dayana Puspawarna; Ngakan Satria Wibawa; Agung Kesuma Putra; Bagas Aditya Kurnia Pratama; Eva Santhy; Adi Arya; Miracle Lie; Herliana Yuliartha; Arnelia Tasau; Arya Giri Prebawa; Saraswati Laksmi Dewi
International Journal of Biomedical Science and Travel Medicine Vol. 1 No. 2 (2024)
Publisher : Publication Department, Universitas Warmadewa

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22225/ijbstm.1.2.2024.37-44

Traveler’s diarrhea (TD) remains a prevalent condition affecting individuals traveling to regions with varying sanitation standards. The diagnosis of TD has evolved with advancements in diagnostic tools and a better understanding of its etiology. Traditionally diagnosed based on clinical presentation and exposure history, current approaches increasingly incorporate molecular techniques to identify causative pathogens more accurately. Recent updates highlight the integration of polymerase chain reaction (PCR) and other molecular diagnostic methods that offer rapid, sensitive, and specific detection of bacterial, viral, and parasitic pathogens. These advances enable differentiation between infectious and non-infectious causes of diarrhea, which is crucial for effective management and treatment. Additionally, the role of stool cultures, although less commonly used in rapid diagnostics, remains important for comprehensive pathogen identification. Emerging research emphasizes the need for a tailored diagnostic approach considering geographic region, patient history, and symptom profile. The use of multiplex assays and metagenomic sequencing is showing promise in identifying a broad spectrum of pathogens and understanding the complex microbiological landscape of TD. This update underscores the importance of adopting a multifaceted diagnostic strategy to improve the accuracy of TD diagnosis, thereby enhancing patient care and contributing to the development of targeted treatment and preventive measures.

Correlation Between Hematocrit Levels and Length of Stay among Dengue Infection Patients at Wangaya General Hospital Nyoman Adi Wirasatya Wibawa; Saraswati Laksmi Dewi; Putu Arya Giri Prebawa; Dewa Ayu Alit Suka Astini
International Journal of Biomedical Science and Travel Medicine Vol. 3 No. 1 (2026)
Publisher : Publication Department, Universitas Warmadewa

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22225/ijbstm.3.1.2026.29-32

Dengue infections, such as Dengue Fever (DF) and Dengue Hemorrhagic Fever (DHF), remain significant public health issues in Indonesia, including Bali Province. The high incidence and mortality rates due to DHF have substantial impacts, particularly concerning treatment costs and length of hospitalization. This study aims to analyze the correlation between hematocrit levels and hospital length of stay among DHF patients at RSUD Wangaya in 2023. The variable studied was hematocrit levels. This research employed an analytical observational method with a retrospective cross-sectional design, using medical record data from DHF patients at RSUD Wangaya from January 1, 2023, to December 31, 2023. Data analysis was conducted using Pearson's correlation test to assess the relationship between hematocrit levels and hospital length of stay. The study results showed that the majority of patients were male (58.3%) and that most were under 50 years old (66.7%). The most common clinical manifestation was fever (98.1%), and most patients had platelet counts below 100,000/µL (77.8%). The average hematocrit was 40.6% in the group with levels <50% and 52.1% in the group with levels ?50%. Bivariate analysis using Spearman's correlation test showed no significant association between hematocrit levels and hospital length of stay among dengue patients (p = 0.835). This study concludes that although hematocrit levels are critical clinical indicators in DHF patients, no significant correlation was found between hematocrit levels and hospital length of stay.

Pengembangan kompetensi staf dan transformasi klinik pada klinik Pratama Puspa Medika, Banjar Kembangsari, Kintamani I Putu Arya Giri Prebawa; Putu Rinawati Jayanti; Ngurah Rai Kusuma Putra
SELAPARANG: Jurnal Pengabdian Masyarakat Berkemajuan Vol 10, No 2 (2026): April
Publisher : Universitas Muhammadiyah Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31764/jpmb.v10i2.38851

Abstrak Sektor pertanian memiliki risiko kecelakaan kerja tinggi yang semakin diperburuk oleh perubahan iklim, terutama melalui peningkatan paparan heat stress dan kondisi kerja ekstrem. Saat ini di Banjar Kembangsari, Desa Satra, Kintamani, layanan kesehatan kerja terstruktur belum tersedia meskipun mayoritas penduduk bekerja sebagai petani. Program Kemitraan Masyarakat ini bertujuan memperkuat kapasitas Klinik Pratama Puspa Medika sebagai Clinic-Centered Occupational Safety Hub melalui integrasi Community-Based First Responder Model in Agricultural Occupational Health. Kegiatan dilaksanakan pada 1 Desember 2025 dengan melibatkan 15 staf klinik. Evaluasi menggunakan desain pre–post test (15 soal). Rerata skor meningkat dari 40 (rentang 20–50) menjadi 70 (rentang 50–80), dengan 80% peserta mengalami peningkatan ≥20 poin. Seluruh peserta menunjukkan peningkatan skor. Hasil ini menunjukkan peningkatan kapasitas respon awal terhadap risiko kecelakaan kerja dan heat stress, serta mendorong transformasi peran klinik dari kuratif menjadi promotif-preventif. Model ini berkontribusi terhadap penguatan layanan kesehatan primer dan mendukung implementasi SDGs 3, 8, dan 13 melalui pendekatan adaptif berbasis komunitas. Pendekatan ini berpotensi direplikasi pada wilayah agraris dengan karakteristik serupa. Kata kunci: kesehatan kerja; pertanian; P3K; perubahan iklim; pengabdian masyarakat Abstract The agricultural sector is associated with a high risk of occupational injuries, which has been further exacerbated by climate change, particularly through increased exposure to heat stress and extreme working conditions. In Banjar Kembangsari, Satra Village, Kintamani, structured occupational health services are not yet available despite the majority of residents being engaged in farming. This Community Partnership Program aimed to strengthen the capacity of Klinik Pratama Puspa Medika as a Clinic-Centered Occupational Safety Hub through the integration of the Community-Based First Responder Model in Agricultural Occupational Health. The activity was conducted on December 1, 2025, involving 15 clinic staff members. Evaluation employed a pre–post test design consisting of 15 questions. The mean score increased from 40 (range 20–50) to 70 (range 50–80), with 80% of participants achieving an improvement of ≥20 points. All participants demonstrated score improvement. These findings indicate enhanced early response capacity to occupational injury risks and heat stress, as well as a transformation of the clinic’s role from curative to promotive-preventive services. The model contributes to strengthening primary health care services and supports the implementation of SDGs 3, 8, and 13 through a community-based adaptive approach. This approach has the potential to be replicated in other agricultural regions with similar characteristics. Keywords: occupational health; agriculture; first aid; climate change; community partnership.

Pemberdayaan masyarakat sebagai pendamping keluarga diabetes melitus untuk mencapai Sustainable Development Goals ketiga Sri Masyeni; Saraswati laksmi Dewi; Arya Giri Prebawa; Gita Pritayanti Dinar
KACANEGARA Jurnal Pengabdian pada Masyarakat Vol 9, No 2 (2026): Mei
Publisher : Institut Teknologi Dirgantara Adisutjipto

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.28989/kacanegara.v9i2.2880

Dampak kesehatan global dari diabetes melitus telah diterima secara luas di berbagai tempat. Program pelayanan masyarakat yang menangani diabetes memainkan peran penting dalam meningkatkan kesehatan masyarakat dengan mempromosikan kesadaran, pencegahan, pengelolaan penyakit, dan pencegahan komplikasi. Tujuan dari pelayanan masyarakat ini adalah untuk meningkatkan pengetahuan para mitra dalam membimbing pasien. Metode program ini meliputi diskusi kelompok fokus untuk mengidentifikasi masalah mitra, penyuluhan pendidikan, permainan peran dengan tes pra dan pasca untuk mengevaluasi peningkatan, dan evaluasi program. Hasilnya menunjukkan peningkatan pengetahuan mitra tentang diabetes melitus sebesar 80%. Dengan melibatkan masyarakat dalam langkah-langkah kesehatan proaktif, program-program ini tidak hanya bertujuan untuk mengurangi prevalensi diabetes tetapi juga berupaya meningkatkan kualitas hidup bagi mereka yang terkena dampaknya, yang pada akhirnya berkontribusi pada komunitas yang lebih sehat dan pencapaian SDGs ke-3.

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