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All Journal Qanun Medika - Medical Journal Faculty of Medicine Muhammadiyah Surabaya Jurnal Penelitian Pendidikan IPA (JPPIPA)
Verna Biutifasari
Universitas Hang Tuah
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Education Health Professions Materials Science & Nanotechnology Medicine & Pharmacology Physics

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The Antibacterial Activities of Piper betle and Allium cepa Extracts Against Staphylococcus aureus Vendra Setiawan; Nathanel Triono; Astrid Karindra Agustina; Lovely Anastasia Moira; Verna Biutifasari; Krisyanti Budipramana
Jurnal Penelitian Pendidikan IPA Vol 11 No 9 (2025): September
Publisher : Postgraduate, University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jppipa.v11i9.10850

Abstract

Indonesia rich in biodiversity, both animals and plants. This is known as ethnobotany. Local people learn to use natural herbs to meet their daily needs, and some commonly used herbs are Piper betle (betel leaf) and Allium cepa (red onion). They often use P. betle or A. cepa to cure various skin infections, one of which is furuncles. This study aimed to explore ethanol extracts of P. betle, A. cepa, and their combination against Staphylococcus aureus, the main bacterial cause of furuncles, using petri dish. The inhibition zones in petri dishes were measured using a caliper to evaluate the antibacterial efficacy. Each sample was tested with 3 replicates and kanamycin was used as positive control. The P. betle extract exhibited the strongest inhibitory effect with an inhibition zone of 17.70 ± 0.30 mm, followed by P. betle and A. cepa with ratio 1:1 produced an inhibition zone of 15.63 ± 0.58 mm. The ethanol extract of A. cepa showed the lowest inhibition zone only 14.38 ± 0.35 mm and this inhibition zone was similar to that of kanamycin as positive control.
Analysis of Antifungal Activity of Artocarpus camansi Leaf Extract Against Malassezia furfur: An In Vitro Experimental Study Megan Seelena; Renata Prameswari; Verna Biutifasari; Stefanus Djoni Husodo
Qanun Medika - Jurnal Kedokteran FK UMSurabaya Vol 10 No 02 (2026): Qanun Medika Vol 10 No 02 July 2026
Publisher : Universitas Muhammadiyah Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30651/jqm.v10i02.30728

Abstract

A lipophilic fungus, Malassezia furfur, is responsible for several skin diseases. The conventional treatment is ketoconazole, but concerns about adverse effects and resistance have prompted the search for natural alternatives such as Artocarpus camansi, whose effectiveness remains poorly understood despite its bioactive flavonoid and steroid content. The purpose of this study was to assess the in vitro antifungal activity of leaf extract from Artocarpus camansi against Malassezia furfur at doses of 25%, 50%, 75%, and 100%. This laboratory experimental study employed the disc diffusion method. Kruskal-Wallis and Mann-Whitney U tests were used to assess and statistically analyze the inhibition zones of the therapy Artocarpus camansi leaf extract at doses of 25%, 50%, 75%, and 100%, with four replications each. The mean inhibition zone for the positive control was 9.53 mm. On the other hand, no inhibitory zone (6.00 mm diameter) was formed by any of the Artocopus camanci extract doses or the negative control. There were no significant differences between the extract concentrations (p>0.05), but there was a significant difference between the positive control and all extract groups (p=0.014). In conclusion, at the tested concentrations, Artocarpus camansi leaf extract shows no antifungal activity against Malassezia furfur, whereas Ketoconazole remains a useful inhibitor.
Co-Authors Astrid Karindra Agustina Krisyanti Budipramana Lovely Anastasia Moira Megan Seelena Nathanel Triono Renata Prameswari Stefanus Djoni Husodo Vendra Setiawan