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Pauzan
Universitas Bima Internasional MFH
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Education Materials Science & Nanotechnology Physics

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A Interaksi Psikoneuroimunologi: Dampak Stres Psikologis terhadap Fungsi Imunologis Pauzan; Muhammad Khalid Iswadi; Idham Halid
Jurnal Penelitian Pendidikan IPA Vol 11 No 8 (2025): August
Publisher : Postgraduate, University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jppipa.v11i8.12293

Abstract

Psychological stress plays a crucial role in modulating the immune system through complex mechanisms involving interactions between the nervous, endocrine, and immune systems. This review evaluates the impact of acute and chronic stress on immune function and the molecular pathways involved. This study employed a narrative literature review approach to explore the relationship between psychological stress and the immune system from a psychoneuroimmunological perspective. The literature review found that chronic stress has been shown to induce immune system dysregulation through activation of the hypothalamic-pituitary-adrenal (HPA) axis and the sympathetic nervous system, leading to increased levels of glucocorticoid and catecholamine hormones. These hormones influence immune cells, inhibiting the proinflammatory Th1 pathway, enhancing the Th2 response, and causing increased levels of inflammatory cytokines such as IL-6 and TNF-α. Consequently, stress contributes to an increased risk of chronic diseases such as cardiovascular disease, cancer, depression, and diabetes. Meanwhile, short-term acute stress can have adaptive immunostimulatory effects, especially in healthy individuals. The stress response is highly individualized and influenced by a person's biological vulnerability and coping capacity. By understanding the relationship between stress and the immune system in the context of psychoneuroimmunology, preventive approaches and clinical interventions can be developed to minimize the adverse effects of stress on physical and mental health.
Peran Imunologis Air Susu Ibu dalam Perlindungan Imun Bayi: Tinjauan Literatur Pauzan; Ni Nyoman Ariwidiani
Jurnal Penelitian Pendidikan IPA Vol 11 No 11 (2025): November
Publisher : Postgraduate, University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jppipa.v11i11.12532

Abstract

Breast milk is the primary source of nutrition for newborns, providing not only essential nutrients but also rich bioactive components with immunological functions. It plays a critical role in the development and modulation of the infant’s immune system, through both innate immune components such as lactoferrin, lysozyme, and immune cells (macrophages, lymphocytes), and adaptive components like secretory immunoglobulin A (sIgA). Stunting in Indonesia is associated with a number of factors, including poverty, low levels of education, poor parenting techniques, and repeated infections that hinder the absorption of nutrients. This review aims to examine the role of breast milk in supporting the infant immune system, particularly in preventing infections, promoting the colonization of healthy gut microbiota, and stimulating mucosal immune development. The method used was a literature review of scientific articles published over the last 10 years (2015–2025) sourced from PubMed, ScienceDirect, and Google Scholar. The findings reveal that exclusively breastfed infants have a lower risk of respiratory and gastrointestinal infections, as well as atopic dermatitis, and demonstrate a more mature immune response compared to non-breastfed infants. The conclusion of this study confirms that breastfeeding significantly contributes to strengthening the infant immune system through immunoprotective and immunomodulatory mechanisms.
Co-Authors Idham Halid Muhammad Khalid Iswadi Ni Nyoman Ariwidiani