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Lewi Santoso, Jemima
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Dentistry Health Professions Medicine & Pharmacology Nursing Public Health Veterinary

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Analisis Hubungan Pola Menstruasi dan Pengetahuan Remaja Terhadap Kejadian Anemia pada Remaja Putri di SMA Darut Taqwa Purwosari Tahun 2024 Sari, Cindy Clara; Tabita Hasianna Silitonga, Hanna; Lewi Santoso, Jemima; Ritunga, Imelda; Charles Pardomuan Tua Siahaan, Salmon
Bahasa Indonesia Vol 6 No 2 (2025): Prominentia Medical Journal
Publisher : Universitas Ciputra Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37715/pmj.v6i2.5710

Abstract

Anemia is a significant public health issue in Indonesia, particularly iron deficiency anemia, which has a relatively high prevalence among adolescent girls. Various factors can contribute to this condition, one of which is an irregular menstrual cycle. A deeper understanding of the contributing factors of anemia is essential for adolescent girls in order to prevent this condition. The aim of this study was to determine the correlation between menstrual patterns (frequency, cycle, and duration) and the occurrence of anemia. This research employed a quantitative analytic observational design with a cross-sectional approach. The study was conducted at SMA Darut Taqwa Purwosari. The sample size was determined using the Slovin formula and a simple random sampling technique, resulting in 253 female students as participants. Data collection was performed using the Fora 6 Plus device to measure hemoglobin levels, and a questionnaire to assess the respondents’ menstrual cycles. Data analyses were processed using SPSS software with the Chi-square test. The results showed that 39.1% of students experienced anemia, 32.8% had increased menstrual volume, 38.7% had prolonged menstrual cycles, and 48.2% had extended menstrual duration. The Chi-square test revealed a significant relationship between menstrual patterns (volume, cycle, and duration) and the incidence of anemia with a p-value < 0.001. The study concludes that there is a significant correlation between menstrual patterns and the occurrence of anemia among adolescent girls at the study site.
Pengaruh Ekstrak Kulit Manggis Terhadap Histologi Jumlah Sel Nekrosis Pulau Langerhans Tikus Putih Jantan Hiperglikemik Lewi Santoso, Anna; Lewi Santoso, Jemima
Bahasa Indonesia Vol 6 No 2 (2025): Prominentia Medical Journal
Publisher : Universitas Ciputra Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37715/pmj.v6i2.6012

Abstract

The aim of this study was to analyze the histological profile of necrotic cell counts in the islets of Langerhans in hyperglycemic male white rats given mangosteen peel extract. Hyperglycemic conditions can form reactive oxygen species (ROS)/free radicals. Excessive ROS can cause oxidative stress and exacerbate cell necrosis in the islets of Langerhans. Mangosteen peel contains the antioxidant compound, Xanthone, an organic compound derived from diphenyl-γ-pyrone that can neutralize ROS and inhibit islet cell necrosis. This study employed a randomized post-test-only control group design. Four groups of male white rats: the untreated group (normal), the alloxan-induced group, the 250, and 500 mg/kgBW dose groups. The data results were tested using Kruskal-Wallis. The results of the study indicated that mangosteen peel extract had an effect on the histological profile of necrotic cell counts in the islets of Langerhans in male white rats experiencing hyperglycemia; with the number of necrotic cells decreased, the mangosteen peel extract dose of 250 mg was 19.2, and the dose of 500 mg was 18.4. Mangosteen peel extract had an effect on necrotic cells in the islets of Langerhans
Co-Authors Anna Lewi Santoso Charles Pardomuan Tua Siahaan, Salmon Hanna Tabita Hasianna Silitonga Imelda Ritunga SARI, CINDY CLARA