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All Journal Sanitas: Journal of Health, Medical, and Psychological Studie
Nurulloh Badar Manggalani
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Health Professions Medicine & Pharmacology

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Pengaruh Pemberian Ekstrak Etanol Bunga Telang terhadap Kadar Il-8 (Interleukin-8) (Studi Eksperimental pada Tikus Putih Jantan Galur Wistar yang dipapar Asap Rokok) Nurulloh Badar Manggalani; Eni Widayati
Journal of Health, Medical, and Psychological Studies Vol 1 No 3 (2026): April: Sanitas: Journal of Health, Medical, and Psychological Studies
Publisher : CV SCRIPTA INTELEKTUAL MANDIRI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.65310/5xanz849

Abstract

Exposure to cigarette smoke increases oxidative stress and triggers pulmonary inflammation through an increase in Reactive Oxygen Species (ROS), which leads to an increase in interleukin-8 (IL-8). Clitoria ternatea (butterfly pea flower) is rich in anthocyanins, which have antioxidant and anti-inflammatory properties. This experimental study with a post-test only control group design aims to assess the effect of butterfly pea flower ethanol extract on IL-8 levels in male Wistar rats exposed to cigarette smoke. The subjects were divided into normal, negative control, positive control (aspirin 9 mg/kgBW), and two treatment groups with doses of 200 mg/kgBW and 400 mg/kgBW. IL-8 levels were measured using immunological methods. The results showed that IL-8 levels were highest in the negative control group (97.712 ± 0.717 ng/mL) and lowest in the normal group (40.306 ± 0.377 ng/mL). Administration of aspirin and extract doses of 200 mg/kgBW and 400 mg/kgBW significantly reduced IL-8 levels compared to the negative control (p < 0.05). The 400 mg/kgBW dose (42.888 ± 0.350 ng/mL) showed the most effective effect and was comparable to aspirin.  
Co-Authors Eni Widayati