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All Journal Jurnal Biologi dan Pembelajarannya (JBP) Science Get Journal
Kun Mardiwati Rahayu
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Education Health Professions Immunology & microbiology Mathematics Physics

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Evaluation of Microplastic Content in Human Circulatory System and Its Potential Impacts on Systemic Health Kun Mardiwati Rahayu; Mila Sari; Pratiwi Ratih Halimatus Sya'diah
Science Journal Get Press Vol 3 No 1 (2026): January, 2026
Publisher : CV. Get Press Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.69855/science.v3i1.357

Abstract

Given the escalating global production of plastics and the absence of regulatory frameworks addressing internal human exposure, microplastic contamination has emerged as an urgent environmental and public health policy concern.Using micro Fourier transform infrared spectroscopy (FTIR) and Raman spectroscopy, MPs were detected in 76.0% of samples collected from 50 healthy adults, with an average concentration of 3.15 ± 1.25 particles/mL and a mean particle size of 5.8 ± 2.1 μm. Polyethylene terephthalate (PET) and polypropylene (PP) were the dominant polymer types, while fragments and fibers represented the most common morphologies. Correlation analyses revealed significant positive associations between total MP concentration and inflammatory biomarkers C-reactive protein (r = +0.415, p = 0.003) and interleukin-6 (r = +0.288, p = 0.043) as well as oxidative stress marker malondialdehyde (r = +0.350, p = 0.013), suggesting that MPs may contribute to subclinical systemic inflammation and oxidative imbalance. These findings provide empirical evidence supporting the systemic circulation of MPs and their potential role as low-grade biological stressors that could influence vascular homeostasis. Further longitudinal and mechanistic studies are warranted to elucidate causal pathways, characterize nanoplastic fractions, and establish standardized analytical protocols. This research underscores the growing necessity to treat microplastic exposure as a critical environmental and public health issue.
Aktivitas Antibakteri Ekstrak Daun Angsana (Pterocarpus indicus) terhadap Staphylococcus aureus dan Salmonella typhimurium Kun Mardiwati Rahayu; Syaharani Latifah
Jurnal Biologi dan Pembelajarannya (JB&P) Vol 13 No 1 (2026): APRIL 2026
Publisher : Universitas Nusantara PGRI Kediri

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29407/jbp.v13i1.28604

Abstract

Bacterial infections caused by Staphylococcus aureus and Salmonella typhimurium remain a global health problem, particularly with increasing antibiotic resistance. This study aims to analyze the phytochemical profile and test the antibacterial activity of angsana (Pterocarpus indicus) leaf extract against these two bacteria. The study used an experimental method with a Completely Randomized Design (CRD) consisting of four extract concentrations (10%, 20%, 40%, and 80%), a positive control (chloramphenicol), and a negative control (DMSO), each with six replications. Antibacterial activity was tested using the Kirby-Bauer disc diffusion method, with the observation parameter being the diameter of the inhibition zone. The results showed that angsana leaf extract had concentration-dependent antibacterial activity against Staphylococcus aureus and Salmonella typhimurium, with the highest inhibition at 80% concentration of 19.69 mm and 19.24 mm, respectively (strong category). Comparatively, Salmonella typhimurium was more sensitive at medium concentrations, while Staphylococcus aureus showed a higher response at maximum concentrations. Although the extract's activity was still lower than chloramphenicol, these results demonstrate the potential of angsana leaf extract as a broad-spectrum antibacterial agent against both Gram-positive and Gram-negative bacteria. Therefore, angsana leaf extract has the potential to be developed as an alternative or complementary therapy in controlling bacterial infections, although further research is needed to optimize its effectiveness and further examine its mechanism of action.
Co-Authors Mila Sari Pratiwi Ratih Halimatus Sya'diah Syaharani Latifah