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All Journal Indonesian Journal of Jamu
Harefa, Siwardin
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Medicine & Pharmacology

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LC-MS/MS Profiling and Anti-inflammatory Activity of Red Onion (Allium cepa L. var. Bima Brebes) Extract-Based Liniment in Mus musculus Saragih, Melisa; Harefa, Siwardin; Rahel, Kezia; Ruhi, Ratu Sukma; Rahmaningtyas, Ekarin Lativa; Eliasari, Laurencia Chrisiana; Riskianto, Riskianto
Jurnal Jamu Indonesia Vol. 11 No. 1 (2026): Jurnal Jamu Indonesia
Publisher : Tropical Biopharmaca Research Center, IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/jji.v11i1.422

Abstract

Allium cepa L. (Bima Brebes variety) is a prolific source of quercetin-type flavonols and organosulfur compounds, recognized for their potent anti-inflammatory and antioxidant activities.  Topical herbal liniments offer a practical approach to manage localized inflammation while minimizing systemic exposure. This study aimed to evaluate the anti-inflammatory activity of a topical liniment formulated with a 70% ethanolic extract of A. cepa. LC–MS/MS (UHPLC Vanquish Tandem Q) had identified ten secondary metabolites putatively linked to anti-inflammatory effects. Anti-inflammatory efficacy was evaluated in vivo using a carrageenan-induced paw oedema model in male mice. Oedema inhibition was recorded at 18% in the negative control, 47% in the positive control, and 38%, 42%, and 44% for the 2 g, 3 g, and 5 g formulations, respectively. One-way ANOVA revealed significant differences among groups (p = 0.001). These findings suggested that A. cepa-based liniment formulations may serve as promising candidates as natural topical anti-inflammatory agents.
Co-Authors Eliasari, Laurencia Chrisiana Rahel, Kezia Rahmaningtyas, Ekarin Lativa Riskianto Riskianto Ruhi, Ratu Sukma Saragih, Melisa