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All Journal Acta Chimica Asiana
Baiq Desy Ratnasari
Department of Chemistry and biochemistry, University of North Carolina, Greensboro, USA
Chemistry

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Synthesis and characterization of 2,4,6-trihydroxy benzophenone and its activity as sunscreen Emmy Yuanita; Ainni Rohmana; Maria Ulfa; Baiq Nila Sari Ningsih; Sudirman Sudirman; Ni Komang Tri Dharmayani; Ima Arum Lestarini; Maulida Septiyana; Baiq Desy Ratnasari
Acta Chimica Asiana Vol. 8 No. 1 (2025)
Publisher : The Indonesian Chemical Society, Chapter Nusa Tenggara and The University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/aca.v8i1.175

Abstract

Benzophenone was synthesized through a condensation reaction of benzoic acid and phloroglucinol with an Eaton reagent as a catalyst. The percentage of the product was 60%, and it was characterized using FTIR and 1H-NMR. The sunscreen activity was carried out using a UV-Vis spectrophotometer to calculate the SPF value. The synthesis result was made in several concentration variations: 100, 150, 200, 250, and 300 ppm to measure the SPF values. The results showed that the SPF values were 9.89, 13.39, 17.83, 23.77, and 28.26, respectively. Based on this, it can be concluded that these compounds have biological activity as sunscreen and samples of 200-300 ppm are included in the ultra-category as sunscreen.
Molecular docking study of mutant levansucrase (E342A) from Bacillus subtilis as a receptor for D-glucopyranose and β-D-fructofuranose ligands: Molecular docking study of mutant levansucrase Diah Miftahul Aini; Firda Ade Irmayanti; Emmy Yuanita; Maulida Septiyana; Baiq Desy Ratnasari
Acta Chimica Asiana Vol. 8 No. 2 (2025)
Publisher : The Indonesian Chemical Society, Chapter Nusa Tenggara and The University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/aca.v8i2.262

Abstract

Molecular docking is a widely applied computational approach for predicting the binding modes of small-molecule ligands within the active site of a target protein. This research investigated the interactions of mutant levansucrase E342A from Bacillus subtilis (PDB ID: 1PT2) for β-D-fructofuranose and D-glucopyranose ligands. Using AutoDock Vina, the docking results indicated that β-D-fructofuranose exhibited a higher binding energy of –5.6 kcal/mol, compared to D-glucopyranose with a value of –5.4 kcal/mol, suggesting a more stable interaction. It was supported by the binding interaction analysis of β-D-fructofuranose, which established five hydrogen bonds, including direct interactions with the key catalytic residues Asp86 (2.76 Å) and Asp247 (2.64 Å) that are essential for the enzymatic reaction. In contrast, D-glucopyranose formed four hydrogen bonds, involving Arg360 (3.07 Å) and Glu340 (2.64 Å), with most residues contributing to structural stabilization rather than direct catalysis. These results confirm that β-D-fructofuranose plays a crucial role as a determinant of levansucrase activity in the biosynthesis of levan-type FOS, which are known to exhibit strong prebiotic activity.
Co-Authors Ainni Rohmana Baiq Nila Sari Ningsih Diah Miftahul Aini Emmy Yuanita Emmy Yuanita Firda Ade Irmayanti Ima Arum Lestarini Maria Ulfa Maulida Septiyana Maulida Septiyana Ni Komang Tri Dharmayani Sudirman Sudirman