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All Journal CAKRA KIMIA (Indonesian E-Journal of Applied Chemistry) Jurnal Biologi Tropis Indonesian Journal of Pure and Applied Chemistry Justek : Jurnal Sains Dan Teknologi Acta Chimica Asiana Indonesian Journal of Global Health research Jurnal Ilmiah Medicamento Journal of Pharmaceutical and Health Research Jurnal Pengabdian Masyarakat Formosa (JPMF) Jurnal Sains dan Teknologi Jurnal Pengabdian Inovasi Masyarakat Indonesia
Diah Miftahul Aini
University Of Mataram
Aerospace Engineering Agriculture, Biological Sciences & Forestry Automotive Engineering Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Control & Systems Engineering Decision Sciences, Operations Research & Management Dentistry Education Electrical & Electronics Engineering Energy Engineering Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Languange, Linguistic, Communication & Media Mathematics Mechanical Engineering Medicine & Pharmacology Nursing Public Health Social Sciences Veterinary Other

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Uji Aktivitas Antiradikal Biji Pare (Momordica charantia L) Menggunakan Metode DPPH Serta Analisis Metabolit Sekundernya Baiq Desy Ratnasari; Diah Miftahul Aini; Imam Syahputra Yamin; Gladeva Yugi Antari
Jurnal Ilmiah Medicamento Vol 8 No 1 (2022): Jurnal Ilmiah Medicamento
Publisher : Fakultas Farmasi Universitas Mahasaraswati Denpasar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36733/medicamento.v8i1.3352

Abstract

Momordica charantia L seed is classified as the domestic waste even though it has many health benefits, namely as anti-tumor, anti-virus, and as a medicine to increase the body resistance. Therefore, this study was designed to examine the antioxidant activity of the ethanol extract of the seeds using the DPPH method. Furthermore, a GC-MS analysis will be carried out to determine the chemical compounds that play a role in the bioactivity. Based on the absorbance of DPPH in three repetitions, the average value of DPPH inhibition by 95% ethanol extract of bitter melon seeds was 60.45%, in which classified as a good radical absorbance. The GC-MS results showed that the ethanol extract of bitter melon seeds contained ten chemical compounds consisting of sesquiterpenes, fatty acids, and alkanes, which affecting the radical absorbance of M. charantia extract.
Pemanfaatan Kulit Buah Manggis Sebagai Bahan Campuran dalam Panganan Manyarakat Sebagai Upaya Penanganan Limbah Kulit Manggis di Daerah Desa Gegelang, Lombok Barat Khairul Pahmi Rahmawati; Abdul Muin; Diah Miftahul Aini; Baiq Desy Ratnasri; Faelga Sara Rosiana
Jurnal Pengabdian Masyarakat Formosa Vol. 1 No. 2 (2022): Juni, 2022
Publisher : PT FORMOSA CENDEKIA GLOBAL

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (382.303 KB) | DOI: 10.55927/jpmf.v1i2.538

Abstract

This activity is presented to handle waste as well as to improve  public health by utilizing medicinal raw materials that have not been used optimally by the community into food or beverages that are pleasant to consume. This service was carried out in Gegelang Village, Lingsar District, West Lombok, in collaboration with the local village PKK driving team. The target of this service is the village community, especially mothers who are the heart of the family who serve food in the middle of the family every day.  This service was carried out in the early months of February 2022. Community service received a positive response from the community, as evidenced by a high level of satisfaction. Furthermore, this service activity succeeded in inviting the community to use mangosteen peel extract for food additives.
Chemical constituents of ripe Momordica charantia by Gas Chromatography Mass Spectrometry (GCMS) Diah Miftahul Aini; Baiq Desy Ratnasari; Zul Hendry
INSOLOGI: Jurnal Sains dan Teknologi Vol. 1 No. 3 (2022): Juni 2022
Publisher : Yayasan Literasi Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (312.429 KB) | DOI: 10.55123/insologi.v1i3.359

Abstract

Momordica charantia, commonly called bitter melon, is a plant belonging to Cucurbitaceae family known for centuries for its nutritional properties. This plant have been used as folklore medicine for the management of hypertensions, cold, cough, and diabetes. The aim of the present study was to characterize the chemical constituents of ripe M. charantia from Lombok, Indonesia by Gas Chromatography Mass Spectrometry (GCMS). The method that used is maseration with ethanol as solvent. The ethanol extract of ripe M. charantia was characterized by gas chromatography-flame ionization detection and gas chromatography coupled with mass spectrometry analyses. The chemical constituent of ripe M. charantia that followed by GCMS were 2,4-Pentanediol (23,61 %), Eucalyptol (1,8-Cineole) (20,41 %), Trans (Beta)-Caryopyllene (10,07 %), 3-Decyn-2-ol  (9.54 %), Epiglobulol (7.82 %), Methyleugenol (7.15%), Beta-Selinene (5.80 %), Alpha-Selinene (5.43 %), and Alpha-Humulene (5.29 %). This is the first report on chemical screening of ethanol extract of ripe M. charantia and GC-MS analysis shows the presence of compounds which have medicinal properties.
PHYTOCHEMICAL SCREENING AND CHEMICAL COMPOTITION OF EUCALYPTUS LEAVES (Melaleuca leucadendron Linn) BY GC-MS Diah Miftahul Aini; Surya Hadi
CAKRA KIMIA (Indonesian E-Journal of Applied Chemistry) Vol 10 No 1 (2022): Cakra Kimia (Indonesian E-Journal of Applied Chemistry)
Publisher : Graduate Program of Applied Chemistry, Udayana University, Bali-INDONESIA

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

ABSTRAK: Saat ini minat terhadap penggunaan tanaman aromatik di berbagai bidang kehidupan berdasarkan sifatnya makin meningkat. Oleh karena itu, pada penelitian ini akan dilakukan uji komposisi kimia daun kayu putih (Melalueca leucadendron Linn.) dari Pulau Lombok dengan menggunakan uji fitokimia dan teknik GC-MS (Gas Chromatography - Mass Spectrometry). Hasil uji fitokimia yang teridentifikasi adalah terpenoid, flavonoid, alkaloid, triterpenoid, tanin, dan saponin. Komposisi kimia dari daun kayu putih (Melalueca leucadendron Linn.) ditentukan oleh GC-MS dari ketiga fraksi yaitu etanol, DCM, dan heksana. Komposisi utama dalam ekstrak etanol adalah asam heksadekanoat (26,69%) dan asam heptadekana-8-karbonat (31,19%), pada DCM yaitu 1,8-cineole (2,31%), asam heksaadekanoik (25.88%), heptadecene-8-carbonic acid (28,75%) Sementara senyawa kimia utama yang ada pada heksana adalah 1,8-cineole (23,31%), 1-phellandren (1,33%), terpineol (1,16%), spathulenol (0,85%), ethanone (3,4-epoxy-2-heksanon) (0.72%), asam heksadekanoat (16,06%), dan heptadecene-8-carbonic acid (19,92%). ABSTRACT : Recently, there has been increasing interest in the use of aromatic plants, which are used in the different areas of life based on various of the plant properties. The aim of this study was to investigate the chemical composition of Eucalyptus leaves (Melalueca leucadendron Linn.) from Lombok Island by phytochemical screening and GC-MS (Gas Chromatography - Mass Spectrometry) technique. The identified phytochemical screening of the leaves was terpenoid, flavonoid, alkaloid, triterpenoid, tannin and saponin. The chemical composition of the leaves was determined by GC-MS (Gas Chromatography - Mass Spectrometry) at three fractions, such as ethanol, DCM, and hexane. The major compounds in ethanol extract are hexadecanoic acid (26.69%) and heptadecene-8-carbonic acid (31,19%) while in the DCM are 1,8-cineole (2.31%), hexadecanoic acid (25.88%), heptadecene-8-carbonic acid (28.75%). Meanwhile, the major compounds in the hexane are 1,8-cineole (23.31%), 1-phellandren (1.33%), terpineol (1.16%), spathulenol (0.85%), ethanone (3,4-epoxy-2-heksanon) (0.72%), hexadecanoic acid (16.06%), and heptadecene-8-carbonic acid (19.92%).
Analisis Pengaruh Penambahan Daun Pegagan (Centella asiatica) terhadap Aktivitas Antioksidan Rimpang Jahe (Zingibere officinale ) Baiq Desy Ratnasari; Diah Miftahul Aini; Gladeva Yugi Antari
Justek : Jurnal Sains dan Teknologi Vol 5, No 2 (2022): November
Publisher : Unversitas Muhammadiyah Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31764/justek.v5i2.11821

Abstract

Abstract:  Zingibere officinale is one of the most widely used herbs as traditional medicine. However, Z. officinale has a distinctive odor and spicy taste that are dislike by some people. Therefore, additional herbs are needed to overcome this problem without affecting its bioactive properties. In this study, Centella asiatica leaves was used as the additional herbs, in accordance with the Indonesian Herbal Medicine Formulary. The aim of this study is to study the synergistic effect between Z. officinalle and C. asiatica by analyzing their antioxidant activity and the chemical compound. The antioxidant assay was conducted with DPPH method. The IC50 value of Z. officinale was 1.28, while the IC50 of C. asiatica was 3.68, and the IC50 of the mixture 1:1 was 2.51. On the other hand, the chemical compound of each samples were analyzed using Gas Chromatography Mass Spectroscopy (GC-MS). Based on the GC-MS chromatogram, Z. officinale has distinctive compounds that affect its taste, aroma, and antioxidant activity such as 1,8-cineol, Zingiberene, and farnesene. On the other hand, C. asiatica also has compounds that regulate aroma and taste, namely Oxacycloheptadec-8-en-2-on or Ambrettolid which is predicted to hindered the spicy taste in Z. officinale. To get a more accurate conclusion, further studies are needed on the synergistic effect of the two extracts in terms of formulation to the synergism of their compounds.Abstrak: Zingibere officinale (Jahe) merupakan salah satu tanaman herbal yang paling banyak digunakan sebagai obat tradisional. Namun, jahe memiliki bau khas dan rasa pedas yang tidak disukai oleh sebagian orang. Oleh karena itu, diperlukan tambahan herbal lain untuk menetralisir aroma dan rasa pedas jahe tersebut tanpa mempengaruhi sifat bioaktifnya. Dalam penelitian ini, daun pegagan digunakan sebagai herbal tambahan, sesuai dengan Formularium Jamu Indonesia. Penelitian ini bertujuan untuk mempelajari efek sinergis jahe dan pegagan yang dilihat dari aktivitas antioksidannya dan keselarasan kandungan senyawa kimia di dalamnya. Aktivitas antioksidan dilakukan dengan metode DPPH. Dari analisis antioksidan didapatkan nilai IC50 jahe adalah 1,28, sedangkan IC50 pegagan adalah 3,68, dan IC50 campuran 1:1 adalah 2,51. Untuk melihat potensi lainnya, maka ekstrak jahe dan pegagan dianalisis dengan menggunakan instrument Gas Kromatografi Spektoskopi Massa (GC-MS). Berdasarkan kromatogram GC-MS, jahe memiliki senyawa khas yang mempengaruhi rasa, aroma, dan aktivitas antioksidannya seperti 1,8-cineol, Zingiberene, dan farnesene. Di sisi lain, pegagan juga memiliki senyawa yang mengatur aroma dan rasa, yaitu Oxacycloheptadec-8-en-2-on atau Ambrettolid yang diduga dapat menghambat rasa pedas pada jahe. Untuk mendapatkan kesimpulan yang lebih akurat, diperlukan penelitian lebih lanjut mengenai efek sinergis kedua ekstrak dari segi formulasi terhadap sinergisme senyawanya.       
Pengaruh Suhu Dekoksi Terhadap Kadar Kurkumin Dan Aktivitas Antioksidan Pada Rimpang Temulawak (Curcuma Zanthorrhiza) Baiq Desy Ratnasari; Diah Miftahul Aini
Journal of Pharmaceutical and Health Research Vol 4 No 1 (2023): February 2023
Publisher : Forum Kerjasama Pendidikan Tinggi (FKPT)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47065/jharma.v4i1.2850

Abstract

One of the medicinal plants that are widely used and available is Curcuma xanthorrhiza. In a daily consumption, C. xanthorrhiza is processed into herbal drinks through a decoction process. However, many biological activities of a plant may be sensitive to the temperature due. Thus, this study is analyzing the effect of temperature on one of the major compounds of C. xanthorrhiza, namely curcumin, along with its antioxidant activity. This research was conducted to obtain the optimum temperature for C. xanthorrhiza processing in order to standardize it as phytopharmaca product. The results showed that a temperature of 100oC was the optimal temperature for the decoction with an extraction rate of 8 ppm and an antioxidant activity of 165 ppm. The curcumin content seems not too sensitive to temperature when seen from the levels obtained at 70oC, 90oC and 100oC which are both 8 ppm. On the other hand, the antioxidant activity of C. xanthorrhiza at temperatures below 100oC has no significant activity which indicates the effect of temperature on its antioxidant activity. The curcumin standard itself has an IC50 of 120 ppm while the IC50 of vitamin C is 24.3 ppm. As it seen from the insignificant antioxidant activity of the decoction extract below 100oC, it is possible that there are other compounds besides curcumin which are extracted only at 100oC which has the agonist effect on the antioxidant activity
Ekstrak Jeruk Nipis Sebagai Obat Terapi Penyembuhan Penyakit Gastritis dengan metode GC-MS Khairul Pahmi Rahmawati; Diah Miftahul Aini; Winda Harnianti
Journal of Pharmaceutical and Health Research Vol 4 No 1 (2023): February 2023
Publisher : Forum Kerjasama Pendidikan Tinggi (FKPT)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47065/jharma.v4i1.3253

Abstract

Gerd or comonly known as gastritis deseas occure due to inflamation of the gastric mucosa. Drug consumption is no longer safe for the reason of side effect for long term ingestion. Thus, herbal medicine is starting become an option, by employing lime juice for medication or theraphy. Previous study indicated positive response of lime extract for medication on mice. However, the mechanism is yet to be discovered. This study aims to determine the chemical compounds contained in lime extract that responsible for antiulcer activity. The research was carried out in laboratory experimental method, by phytochemical screening than continued by GC-MS. The result shows that lime juice containaing secondary metabolits, namely alkaloid, glycosides, triterpenoid, saponin, polyphenol, flavonoid and phenol that act as an anty-oxidants as well as inductors for formation of stemp cell. Furthermore, GC-MS analysis showed that the presence of citric acid derivatives in the form of citraconic anhindrat, itaconic anhindrat and Itaconic acid, last but not least palmitic acid as part of fatty acid. Citric acid is a compound that has a cappability to be a buffer solution. Therefore, consuming lime juice for gerd medication will help neutralised acidity of the gastric with the principle of buffer solution.
Pemberdayaan Kader Kesehatan Ibu-Ibu Di Lingkungan Monjok Kebon Jaya Barat Melalui Pelatihan Pembuatan Sabun Herbal Daun Kelor (Moringa Oleifera) Aini, Diah Miftahul; Antari, Gladeva Yugi; Ratnasari, Baiq Desy
Jurnal Pengabdian Inovasi Masyarakat Indonesia Vol. 3 No. 2 (2024): Edisi Agustus
Publisher : Program Studi Pendidikan Kimia FKIP Universitas Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jpimi.v3i2.5919

Abstract

Monjok Kebon Jaya Barat, Mataram, has rich natural resource potential, including the Moringa plant (Moringa oleifera) which is known for its skin health benefits. Although the local community has utilised moringa leaves in daily consumption, the great potential for further processing, such as making herbal soap, has not been maximised. Herbal soap made from moringa leaves can be a safer alternative to cleaning products, reduce dependence on harmful chemicals, and support a green economy. This programme aims to empower women health cadres in Monjok Kebon Jaya Barat through skills training in making herbal soap made from moringa leaves. The method used involved three main stages: activity preparation, soap-making training, and sustainability evaluation. In the training, participants were given theoretical and practical knowledge on the benefits of moringa leaves, the saponification process, and herbal soap making. The evaluation showed that most participants were able to follow the training well, although there were some technical constraints related to ingredient measurement and temperature control. The programme had a positive impact on skills enhancement and economic empowerment. The training is effective in introducing herbal soap making and can be a sustainable business opportunity. It is recommended to provide continuous assistance in marketing and the formation of joint business groups to improve the sustainability and welfare of the local community.
Pelatihan Pembuatan Minuman Herbal Daun Pecut Kuda di SMA Darul Hikmah Mataram Rahman, Suburi; Dwiani, Afe; Yuniartini, Ni Luh Putu Sherly; Nugrahani, Rizki; Arini, Laili Azmiati; Patmawati, Patmawati; Salsabila, Riska Dia Salma; Riani, Riani; Maulana, Harpan; Aini, Diah Miftahul
Jurnal Pengabdian Inovasi Masyarakat Indonesia Vol. 3 No. 2 (2024): Edisi Agustus
Publisher : Program Studi Pendidikan Kimia FKIP Universitas Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jpimi.v3i2.5999

Abstract

SMA Darul Hikmah Mataram is one of the private secondary education institutions in the city of Mataram with the existence of a school that is still beautiful and surrounded by many medicinal plants. The existence of horse whip leaves (Stachytarpheta jamaicensis) in this school is very abundant and still underutilised. Horse whip leaves are useful as antioxidants and anti-inflammatories. Chemical compounds contained in horse whip leaves are flavonoids, terpenoids, alkaloids, tannins, steroids, and saponins. Herbal drinks are one of the practical products that can be processed into antioxidant-rich drinks using very cheap and easy packaging. This activity aims to increase the knowledge of teachers and students at SMA Darul Hikmah Mataram about making drinks, educate and increase the use of horse whip leaves as herbal drinks at SMA Darul Hikmah Mataram, show training participants the processing of horse whip leaves as herbal drinks, and increase product value related to packaging and processing of horse whip leaves as herbal drinks. The methods used were preparation, processing of horse whip leaves into powder, and evaluation. Evaluation is carried out through direct interviews and questions and answers. The results of this service are that the participants follow the entire series of activities well and are able to make pecut kuda herbal drinks in powder form and packaging with pouches, this activity is expected to be a government initiation for the development of local agricultural products in the form of herbs that have high selling value.
Halophilic Bacteria as Promising Biocatalyst Producers: A Review on Enzyme Production Aini, Diah Miftahul; Balqis, Solina
Jurnal Biologi Tropis Vol. 25 No. 2 (2025): April-Juni
Publisher : Biology Education Study Program, Faculty of Teacher Training and Education, University of Mataram, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v25i2.9125

Abstract

Halophilic bacteria, a group of extremophiles adapted to high-salinity environments, have emerged as valuable sources of relevant biocatalysts. This review aims to compile and analyse current knowledge on the enzymatic potential of halophilic bacteria. Using a systematic literature review as its primary methodology to collect, examine, and integrate academic findings on halophilic bacteria as promising sources of biocatalysts. This review highlights that halophilic bacteria possess remarkable physiological and biochemical adaptations that enable them to survive osmotic stress, with recent advances in genetic engineering and synthetic biology enhancing their enzyme production and functional efficiency. These findings underscore their potential as robust and efficient biocatalysts for sustainable industrial applications. In conclusion, halophilic bacteria represent valuable resources for biotechnology, particularly in extreme conditions where conventional enzymes fail. Future research should focus on in-depth genomic and proteomic analyses, metabolic engineering for optimized enzyme yields, industrial-scale feasibility studies, environmental impact assessments, and cross-disciplinary collaborations to fully harness their capabilities in real-world applications.
Co-Authors Abdul Muin Adiguna, Sya’ban Putra Antari, Gladeva Yugi Arini, Laili Azmiati Baiq Desy Ratnasari Baiq Desy Ratnasari Baiq Desy Ratnasri Balqis, Solina Damayanti, Eva Hikmatul Dedy Suhendra Dwiani, Afe Emmy Yuanita Erin Ryantin Gunawan Faelga Sara Rosiana Fajriati, Elza Kamila Imam Syahputra Yamin Irmayanti, Firda Ade Khairul Pahmi Rahmawati Maulana, Harpan Maulida Septiyana Patmawati Patmawati, Patmawati Rahman, Suburi Ratnasari, Baiq Desy Riani Riani, Riani Rischia, Amida Rizki Nugrahani, Rizki Salsabila, Riska Dia Salma Sri Seno Handayani Surya Hadi Usiana, Shilan Winda Harnianti Yanti, Sepia Dwi Yuniartini, Ni Luh Putu Sherly Zul Hendry