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All Journal Journal of Natural Product for Degenerative Diseases
Ridel Yosua Rumondor
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Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Public Health

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Liquid Chromatography–Mass Spectrometry in the Development of Natural Product–Based Antihypertensive Drugs: A Systematic Literature Review Nur Pujiastuti; Novi Yantih; Ridel Yosua Rumondor; Kholilah
Journal of Natural Product for Degenerative Diseases Vol. 3 No. 2 (2026): JNPDD March
Publisher : Faculty of Pharmacy Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58511/v3i2.9693

Abstract

Hypertension remains a major global health burden, necessitating effective and evidence-based therapeutic strategies. Natural products have emerged as promising sources of antihypertensive agents; however, their chemical complexity requires advanced analytical techniques such as liquid chromatography–mass spectrometry (LC–MS). This study employed a systematic literature review of articles published between 2020 and 2025, retrieved from Scopus, PubMed, and ScienceDirect using predefined inclusion criteria. The review evaluates the application of LC–MS in the identification, metabolite profiling, and standardization of antihypertensive natural products, with emphasis on celery (Apium graveolens). The findings indicate that LC–MS enables accurate identification of key bioactive compounds, including flavonoids, phenolic acids, alkaloids, and phthalides, which are associated with antihypertensive mechanisms such as angiotensin-converting enzyme (ACE) inhibition, vasodilation, and endothelial protection. Integration with pharmacological and in silico approaches further supports the correlation between chemical composition and biological activity. In conclusion, LC–MS is a critical tool in natural product-based antihypertensive drug discovery, particularly for compound characterization and standardization. However, lack of standardized workflows remains a limitation for reproducibility and clinical translation.
LC–MS in the Development of Natural Product Based Antidiabetic Drugs: A Systematic Review Kholilah Kholilah; Novi Yantih; Ridel Yosua Rumondor; Nur Pujiastuti
Journal of Natural Product for Degenerative Diseases Vol. 3 No. 2 (2026): JNPDD March
Publisher : Faculty of Pharmacy Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58511/v3i2.9692

Abstract

Natural products have great potential as a source for developing antidiabetic drugs, but matrix complexity and phytochemical variations are the main challenges in identifying bioactive compounds. This systematic literature review aims to evaluate the role of liquid chromatography–mass spectrometry (LC–MS) in the development of natural product-based antidiabetic drugs, particularly in type 2 diabetes mellitus (T2DM). The literature search was carried out following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines using the PubMed, Scopus, Web of Science, and ScienceDirect databases. The study results show that LC–MS plays an important role in comprehensive phytochemical profiling, high-confidence metabolite identification, and dereplication of complex natural matrices. Integration of LC–MS with metabolomics and pharmacology approaches provides a deeper mechanistic understanding of antidiabetic effects, including modulation of glucose and lipid metabolism. However, methodological heterogeneity between studies is still an obstacle, so protocol standardization and bioinformatics integration are needed to increase translational relevance towards clinical applications.
Co-Authors Kholilah Kholilah Novi Yantih Nur Pujiastuti