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All Journal Journal of Natural Product for Degenerative Diseases
Nur Pujiastuti
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Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Public Health

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Application of LC–MS in the Development of Natural Product–Based Antidepressant Drugs: A Systematic Literature Review Rumondor, Ridel Yosua; Yantih, Novi; Kholilah; Nur Pujiastuti
Journal of Natural Product for Degenerative Diseases Vol. 3 No. 2 (2026): JNPDD March In Press
Publisher : Faculty of Pharmacy Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58511/v3i2.9690

Abstract

 Due to the shortcomings of existing medications, depression remains a worldwide neuropsychiatric disorder requiring innovative therapeutic strategies. Natural compounds represent promising multi-target antidepressant candidates; however, their chemical complexity necessitates advanced analytical tools. This systematic literature review assessed the application of liquid chromatography–mass spectrometry (LC–MS) in the identification, profiling, and standardization of natural antidepressant compounds. A comprehensive search of major databases was conducted following PRISMA guidelines for studies published between 2014 and 2024, with a total of six eligible studies were included in the qualitative synthesis.. The findings indicate that LC–MS, particularly high-resolution platforms such as QTOF and Orbitrap, is the primary method for metabolite profiling and dereplication of bioactive classes including flavonoids, alkaloids, and phenolic acids. Integration of LC–MS data with in vitro and in vivo models has facilitated the correlation of chemical profiles with pharmacological mechanisms, such as neurotransmitter regulation. Despite its pivotal role in evidence-based natural product research, challenges remain in analytical standardization and clinical translation. In conclusion, LC–MS is an indispensable and transformative tool in the development of natural product-based antidepressants, providing robust chemical characterization that supports pharmacological validation and accelerates drug discovery. Future research should emphasize methodological harmonization and systems biology integration to enhance translational impact. 
Liquid Chromatography–Mass Spectrometry in the Development of Natural Product–Based Antihypertensive Drugs: A Systematic Literature Review Nur Pujiastuti; Novi Yantih; Ridel Yosua Rumondor; Kholilah
Journal of Natural Product for Degenerative Diseases Vol. 3 No. 2 (2026): JNPDD March In Press
Publisher : Faculty of Pharmacy Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58511/v3i2.9693

Abstract

Hypertension remains a major global health burden, necessitating effective and evidence-based therapeutic strategies. Natural products have emerged as promising sources of antihypertensive agents; however, their chemical complexity requires advanced analytical techniques such as liquid chromatography–mass spectrometry (LC–MS). This study employed a systematic literature review of articles published between 2020 and 2025, retrieved from Scopus, PubMed, and ScienceDirect using predefined inclusion criteria. The review evaluates the application of LC–MS in the identification, metabolite profiling, and standardization of antihypertensive natural products, with emphasis on celery (Apium graveolens). The findings indicate that LC–MS enables accurate identification of key bioactive compounds, including flavonoids, phenolic acids, alkaloids, and phthalides, which are associated with antihypertensive mechanisms such as angiotensin-converting enzyme (ACE) inhibition, vasodilation, and endothelial protection. Integration with pharmacological and in silico approaches further supports the correlation between chemical composition and biological activity. In conclusion, LC–MS is a critical tool in natural product-based antihypertensive drug discovery, particularly for compound characterization and standardization. However, lack of standardized workflows remains a limitation for reproducibility and clinical translation.
Co-Authors Kholilah Novi Yantih Novi Yantih Ridel Yosua Rumondor Rumondor, Ridel Yosua