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All Journal AKSELERASI: Jurnal Ilmiah Nasional International Journal of Science and Society (IJSOC)
Yuandani
Universitas Sumatera Utara, Medan, Indonesia
Decision Sciences, Operations Research & Management Economics, Econometrics & Finance Education Engineering Materials Science & Nanotechnology Social Sciences

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REVIEW ARTIKEL BUAH NAGA (Hylocereus polyrhizus) SEBAGAI ANTIOKSIDAN ALAMI Said Haikal Alfajar; Emil Salim; Yuandani; Dadang Irfan Husori; Parhan; Muthia Deviani Johan
AKSELERASI: Jurnal Ilmiah Nasional Vol 7 No 3 (2025): AKSELERASI: JURNAL ILMIAH NASIONAL
Publisher : GoAcademica Research dan Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54783/jin.v7i3.1606

Abstract

Polusi udara terus meningkat setiap tahun sementara fast food menjadi sumber energi yang kurang baik bagi tubuh. Polusi udara dan fast food dapat memicu pembentukan radikal bebas yaitu molekul tidak stabil yang berpotensi merusak sel tubuh. Kerusakan yang ditimbulkan bisa terjadi kanker. Radikal bebas ini dapat dinetralkan dengan bantuan antioksidan, senyawa yang mampu memberikan elektron untuk menstabilkan radikal bebas. Salah satu sumber antioksidan alami yang potensial adalah kulit buah naga (Hylocereus polyrhizus). Kulit buah naga (Hylocereus polyrhizus) mengandung senyawa flavonoid yang dikenal memiliki kemampuan sebagai antioksidan alami yang efektif. Artikel review ini bertujuan untuk mengkaji potensi antioksidan yang terdapat dalam kulit buah naga (Hylocereus polyrhizus). Studi literatur dilakukan melalui pencarian di Google dan Google Scholar untuk mengumpulkan informasi tentang manfaat antioksidan dari kulit buah naga. Artikel penelitian yang dianalisis adalah publikasi yang terbit dalam rentang tahun 2014 hingga 2024. Berdasarkan hasil penelitian yang dihimpun, kulit buah naga (Hylocereus polyrhizus) terbukti memiliki potensi besar sebagai sumber antioksidan alami.
Antihyperlipidemic Activity of Kratom Leaves (Mitragyna speciosa) In Vivo and In Silico Sintia Karina Putri; Yuandani; Pipit Pitriani; Said Haikal Alfajar; Rony Abdi Syahputra
International Journal of Science and Society Vol 8 No 2 (2026): International Journal of Science and Society (IJSOC)
Publisher : GoAcademica Research & Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54783/ijsoc.v8i2.1675

Abstract

Obesity and hyperlipidemia are metabolic problems that can trigger various comorbid diseases. Kratom leaves (Mitragyna speciosa) are one of the herbal-based medicines containing alkaloid compounds that have the potential to improve lipid profiles. This study aims to analyze the antihyperlipidemic activity of kratom leaves in vivo and in silico. Extraction of kratom leaves was carried out by maceration using 96% ethanol (1:10 w/v) for 3 days, then concentrated using a rotary evaporator. Compound identification was performed using LC-MS/MS. The in vivo study was conducted on rats (n=6 per group) for 14 days, including a negative control, positive control, and three treatment groups with doses of kratom leaf extract of 100, 300, and 500 mg/kg BW. The parameters assessed included body weight, LDL cholesterol, HDL cholesterol, triglycerides, and total cholesterol, as well as molecular docking using PyRx. The results showed that kratom leaf extract at doses of 100, 300, and 500 mg/kg BW exhibited significant antihyperlipidemic activity compared to the negative control (p<0.05), characterized by reductions in triglyceride, total cholesterol, and LDL levels, as well as an increase in HDL and a decrease in body weight. The 500 mg/kg BW dose showed the best pharmacological effect compared to the 100 mg/kg BW and 300 mg/kg BW doses (p<0.05). The docking results confirmed strong binding affinities between kratom leaf alkaloids and the therapeutic target HMG-CoA. Thus, kratom leaf alkaloids have the potential to be developed as antihyperlipidemic agents through inhibition of the HMG-CoA reductase enzyme.
Co-Authors Dadang Irfan Husori Emil Salim Muthia Deviani Johan Parhan Pipit Pitriani Rony Abdi Syahputra Said Haikal Alfajar Said Haikal Alfajar Sintia Karina Putri