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All Journal Sasambo Journal of Pharmacy Journal of Community Engagement in Health
Anggi Nur Prasetio
Universitas STRADA Indonesia
Dentistry Health Professions Medicine & Pharmacology Nursing Public Health Veterinary

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CARE: Diabetes Screening With The Utilization of Family Medicinal Plants (TOGA) Riza Tsalatsatul Mufida; Sherly Anggraini Wiyono; Vhiendy Putri Destiananda; Saiva Alifia; Vestin Aulia Firdaus; Citra Dewi Anggraini; Lutfhia Putri Andarista; Reandi Ayana Messi; Muhaimin; Kania Sukma Lembar Diningrum; Risma Dwi Utami; Valeria Oktaviani Kasna; Anggi Nur Prasetio; Susanti Inya Mete; Riza Niko Alviyansyah
Journal of Community Engagement in Health Vol. 9 No. 1 (2026): March
Publisher : Universitas STRADA Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30994/jceh.v9i1.802

Abstract

Health is a fundamental pillar of community life, closely linked to quality of life and productivity. One promising preventive effort closely linked is the utilization of Family Medicinal Plants (TOGA), which are herbal plants cultivated in home gardens and known for their medicinal properties. This community service program aims to enhance the knowledge and skills of residents in Mangunrejo Village, particularly in Dusun Munengan, in processing TOGA into safe, practical, and economically valuable health beverage products. The method used to employ in this program involves a participatory approach through education, training, and community mentoring. The plants focused on are clove, sappan wood, and cinnamon, which contain active compounds such as eugenol, brazilin, and cinnamaldehyde—proven to have health benefits such as antioxidant, antidiabetic, and anti-inflammatory effects. Residents were actively involved in every step, from plant identification and processing to the development of final products such as herbal tea bags and ready-to-drink spiced beverages.
In silico study of potential alkaloid compounds in Kratom Leaves (Mitragyna speciosa) as CNS stimulant Anggi Nur Prasetio; Sentot Purwandi; Sri Rahayu Dwi Purnaningtyas; Luluk Aniqoh Meliana Putri; Devita Riafinola Andaririt
Sasambo Journal of Pharmacy Vol. 7 No. 2 (2026): September
Publisher : Universitas Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/sjp.v7i2.685

Abstract

Dysfunction of Central Nervous System (CNS) is often associated with various neurological and psychiatric disorders. The use of stimulant can improve CNS function. Kratom leaves (Mitragyna speciosa) are predicted to have potential as CNS stimulant candidate through the inhibition of dopamine transporter (DAT) receptor. The objective of this study is to determine potential of alkaloid compounds contained in kratom leaves as CNS stimulant using in silico approach. This study was conducted in silico through the prediction of physicochemical properties (SwissADME), pharmacokinetic profiles (pkCSM), and molecular docking. The target protein used for DAT receptor was SLC6A3 with PDB ID: 8Y2C and 9EO4. The results showed that five test compounds met Lipinski’s Rule of Five. Pharmacokinetic predictions show that five test compounds have good pharmacokinetic profiles, with favorable absorption and distribution, although some compounds have potential to cause drug interactions and certain toxicities. Mitragynine, Paynantheine, Speciogynine, and Speciociliatine, have potential as CNS stimulants by inhibiting the DAT receptor, with binding energies ranging from -6,2 to -8,3 kcal/mol. Four of the five alkaloids in kratom leaves are predicted to have potential as CNS stimulants by inhibiting DAT receptors in silico.
Co-Authors Citra Dewi Anggraini Devita Riafinola Kania Sukma Lembar Diningrum Luluk Aniqoh Meliana Putri Lutfhia Putri Andarista Muhaimin Purnaningtyas, Sri Rahayu Dwi Reandi Ayana Messi Risma Dwi Utami Riza Niko Alviyansyah Riza Tsalatsatul Mufida Saiva Alifia Sentot Purwandi Sherly Anggraini Wiyono Susanti Inya Mete Valeria Oktaviani Kasna Vestin Aulia Firdaus Vhiendy Putri Destiananda