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All Journal Open Access Health Scientific Journal The Indonesian Journal of Computer Science Strada Journal of Pharmacy
Purnaningtyas, Sri Rahayu Dwi
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Chemistry Computer Science & IT Dentistry Electrical & Electronics Engineering Engineering Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health Veterinary

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Analysis of free Fatty Acid Levels (as Lauric Acid) Pure Coconut Oil (Virgin Coconut Oil / VCO) for sale in Kediri City Sri Rahayu Dwi Purnaningtyas
Strada Journal of Pharmacy Vol. 4 No. 1 (2022): April
Publisher : Universitas STRADA Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30994/sjp.v4i1.48

Abstract

Pure Coconut Oil (Virgin Coconut Oil / VCO) is a vegetable oil that contains medium chain saturated fatty acids. The medium-chain saturated fatty acid that has the highest content in virgin coconut oil is lauric acid. Lauric acid can be directly absorbed by the liver and used as an energy source. This study aims to determine the levels of free fatty acids (as lauric acid) in virgin coconut oil (Virgin Coconut Oil/VCO) according to SNI Standard 7381: 2008. The samples used in this study were pure coconut oil from various brands on the market in Indonesia. Kediri city. This study used an alkalimetry method to identify the free fatty acid levels in the sample. From the results of the analysis on 5 (five) brands of virgin coconut oil, it was found that all samples met the requirements of SNI 7381: 2008 which is a maximum of 0.2%. The results of the analysis of the levels of free fatty acids as lauric acid, the smallest 0.1643% and the largest 0.1988% according to the requirements of SNI.
Analysis of Free Fatty Acid Contents (As Acid Laurat) Pure Coconut Oil (Virgin Coconut Oil /VCO) which Circulates in Kediri City Sri Rahayu Dwi Purnaningtyas
Strada Journal of Pharmacy Vol. 4 No. 2 (2022): October
Publisher : Universitas STRADA Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30994/sjp.v4i2.167

Abstract

Pure Coconut Oil (Virgin Coconut Oil / VCO) is a vegetable oil that contains medium chain saturated fatty acids. The medium-chain saturated fatty acid that has the highest content in virgin coconut oil is lauric acid. Lauric acid can be directly absorbed by the liver and used as an energy source. This study aims to determine the levels of free fatty acids (as lauric acid) in virgin coconut oil (Virgin Coconut Oil/VCO) according to SNI Standard 7381: 2008. The samples used in this study were pure coconut oil from various brands on the market in Indonesia. Kediri city. This study used an alkalimetry method to identify the free fatty acid levels in the sample. From the results of the analysis on 5 (five) brands of virgin coconut oil, it was found that all samples met the requirements of SNI 7381: 2008 which is a maximum of 0.2%. The results of the analysis of the levels of free fatty acids as lauric acid, the largest 0.1988% and the smallest 0.1643% according to the requirements of SNI.
The Potential of Quercetin as Parkinson's Disease Therapy Assessed From Binding Affinity To Adenosine A2a Receptor Using In-Silico Adjie Wahyu Pradana; Sri Rahayu Dwi Purnaningtyas; Devita Riafinola Andaririt; Luluk Aniqoh Meliana Putri
Strada Journal of Pharmacy Vol. 7 No. 1 (2025): April
Publisher : Universitas STRADA Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30994/sjp.v7i1.156

Abstract

Parkinson's disease is a degenerative disease that causes impaired mobility and muscle control caused by decreased dopamine production in the brain. Parkinson's disease therapy is dopaminergic therapy using levodopa which works by replacing the reduced dopamine, the use of levodopa has side effects such as dizziness, nausea, and excessive sleepiness. The use of istradefylline with levodopa as a non-dopaminergic therapy in parkinson's reduces side effects and increases therapeutic targets. Quercetin is thought to have activity in improving motor function in parkinson's. The aim of this study was to look at the potential of quercetin as a parkinson's therapy. Objective: Finding the activity of quercetin as Parkinson's therapy compared with istradefylline using in-silico. Method: The design of this study is in-silico, which is a study using the help of computer calculations, the method used is molecular docking based on the principle of bonding compounds to receptors. Ligand compounds obtained from PubChem and receptor clusters obtained from Protein Data Bank. The docking Software used is Pyrex, and Discovery Studio Analizer. Independent variables in this study were quercetin and istradefylline, while the dependent variable was binding affinity ligand to adenosine A2a receptor. In this study, statistical analysis was conducted using an independent sample t-test. Results: In-silico test with molecular docking method showed each 9 ligand position to the receptor, the results of data analysis with the test of independent sample t-test, at the degree of significance α = 0.05 obtained statistical results with a significance value of 0.013 which means that the quercetin ligand has stronger potential compared to istradefylline. Quercetin has a binding affinity value of -8.1 kcal/mol, while istradefylline has a binding affinity value of -6.9 kcal / mol. Conclusion: Quercetin has been shown to have potential as an alternative therapy for parkinson's disease
Validation of the UV-Vis Spectrophotometric Method for the Determination of Ascorbic Acid Content in Beverage Preparations Based on a Standard Vitamin C Calibration Curve Andaririt, Devita Riafinola; Purnaningtyas, Sri Rahayu Dwi; Wijayanto, Arif
Open Access Health Scientific Journal Vol. 6 No. 2 (2025): August 2025
Publisher : Griya Eka Sejahtera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55700/oahsj.v6i2.101

Abstract

Background: Vitamin C or ascorbic acid (C₆H₈O₆) is an essential water-soluble compound, widely used in functional beverages due to its antioxidant properties. This compound plays a role in neutralizing free radicals, strengthening the immune system, and helping the absorption of iron in the body. Packaged beverages containing vitamin C can experience degradation due to storage temperature (pH), production process, and the length of product circulation on the market. This impacts degradation of ascorbic acid and decreases the levels of vitamin C in beverage preparations, so accurate and validated analytical methods are needed to ensure the conformity of ascorbic acid levels with the label.Methods: Determination of ascorbic acid levels using a UV-Vis spectrophotometer at maximum wavelength. A standard curve was prepared from a standard vitamin C solution with a concentration of 10–18 ppm, resulting in a regression equation as the basis for calculating sample levels. Method validation included linearity, accuracy, precision, limit of detection (LOD), and limit of quantitation (LOQ) tests according to quantitative analysis guidelines.Results: The standard curve equation is Y = 0.020x + 0.030Y with r2 = 0.995r indicating good linearity. The vitamin C content in the sample is 1.045 mg/140 mL or 103.5% of the label (1000 mg), still within the Pharmacopoeia limits (90–110%). The LOD and LOQ values are 0.429 ppm and 1.3 ppm, respectively. The precision results show a %RSD of 0.1260% and an accuracy (% recovery) of 103.5%.Conclusion:The results showed that the UV-Vis spectrophotometry method had good linearity, accuracy, and precision. The vitamin C content in the product met standards. Validation parameters demonstrated that this method was consistent in analyzing vitamin C in beverage preparations.  
Molecular Docking Of Quercetin As An Anti-Breast Cancer Agent Purnaningtyas, Sri Rahayu Dwi; Andaririt, Devita Riafinola
Open Access Health Scientific Journal Vol. 6 No. 2 (2025): August 2025
Publisher : Griya Eka Sejahtera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55700/oahsj.v6i2.126

Abstract

Background: Breast cancer is a major global health problem and a leading cause of death in women. Flavonoid compounds, particularly quercetin, have been extensively studied for their diverse pharmacological activities, including antioxidant, anti-inflammatory, and anticancer properties. Advances in computational technology in pharmaceutical and medicinal chemistry, particularly molecular docking, offer opportunities to predict interactions between ligands and target receptors quickly, efficiently, and at low cost. This study aimed to identify Molecular Docking Of Quercetin As An Anti-Breast Cancer Agent.Methods: The ligand compounds were obtained from PubChem and the receptor clusters were obtained from the Protein Data Bank. Instrumens used VivoBook_AsusLaptop X409JB Intel ® Core ™ i3-1005G1 CPU @1.20GHz 12 RAM.  The independent variables of this study were Quercetin and Doxorubicin to Cyclin-Dependent Kinase 6 (CDK6).Results: Molecular docking results show that quercetin has an average binding affinity value of –6.19 kcal/mol, while the positive control doxorubicin has an average value of –7.3 kcal/mol against the Cyclin-dependent kinase 6 (CDK6) receptor. Amino acid similarities were found in the receptors for quercetin and doxorubicin. The same bound amino acids were found on the 3NUP, 3NUX, and 4EZ5 receptors with Van Der Walls Bond. Amino acid similarities were found in the receptors for quercetin and doxorubicin. The 4NUP receptor contains the same amino acids: Phenylalanine (A:164) and Histidine (A:143), while the 3NUX receptor contains Lysine (A:26), Valine (A:45), Valine (A:27), and Phenylalanine (A:164). Meanwhile, the 4EZ5 receptor has the same amino acids, namely Glycine (A:22), Glycine (A:20), and Asparagine (A:104). This indicates a similarity in the mechanisms of action between quercetin and doxorubicin.Conclusion: Quercetin has great potential as a candidate for breast cancer treatment
Kebaruan Parameter EEG Kuantitatif Sinyal Stres pada Mahasiswa Cynthia, La Febry Andira Rose; Purnaningtyas, Sri Rahayu Dwi; Syafaah, Lailis; Hasani, Mohammad Chasrun; Basri Noor Cahyadi
The Indonesian Journal of Computer Science Vol. 13 No. 4 (2024): The Indonesian Journal of Computer Science (IJCS)
Publisher : AI Society & STMIK Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33022/ijcs.v13i4.3820

Abstract

Otak merupakan organ yang kompleks yang bisa mengontrol pikiran, ingatan, emosi, indra peraba, kemampuan motorik, penglihatan, pernafasan, suhu dan segala sesuatu yang meregulasi tubuh kita. Gelombang tersebut hanya bisa direkam dan dilihat aktifitasnya melalui alat Elektroensefalogram (EEG). Stres adalah perasaan ketegangan emosional atau fisik. Hal tersebut datang dari segala peristiwa atau pemikiran yang membuat seseorang merasa frustrasi, marah, atau gugup. Stres adalah reaksi tubuh terhadap tantangan atau permintaan. Dalam waktu singkat, stres bisa menjadi positif, seperti saat membantu seseorang menghindari bahaya atau memenuhi tenggat waktu. Tetapi ketika stres berlangsung lama, itu dapat membahayakan kesehatannya. Stress dapat diukur dengan menggunakan kuesioner, namun penggunaan kuesioner bisa dimanipulasi. EEG dapat dikombinasikan sebagai pengukur stress seseorang. Tujuan penelitian ini untuk menganalisis parameter sinyal kuantitatif EEG pada penderita stress. Sehingga harapannya parameter ini dapat digunakan sebagai upaya pencegahan kesalahan interpretasi deteksi stress yang berakibat penurunan produktifitas seseorang. Parameter kuantitatif saat sedang stress diharapkan bisa menjadi keterbarun di dalam penelitian ini.
Co-Authors Adjie Wahyu Pradana Arif Wijayanto Basri Noor Cahyadi Devita Riafinola La Febry Andira Rose Cynthia Mohammad Chasrun Hasani Putri, Luluk Aniqoh Meliana Syafaah, Lailis