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All Journal Biology, Medicine, & Natural Product Chemistry
Sriwijayanti Sriwijayanti
Sekolah Tinggi Analis Kimia Cilegon
Biochemistry, Genetics & Molecular Biology Medicine & Pharmacology Public Health

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LC-MS Analysis of Ethyl Acetate Fraction of Gandaria (Bouea macrophylla Griff.) Stem Bark and Molecular Docking Study against HER2 Protein Junia Salsha Primawati; Sriwijayanti Sriwijayanti; Boima Situmeang; Siti Safuroh; Yuke Agustin
Biology, Medicine, & Natural Product Chemistry Vol 15, No 1 (2026)
Publisher : Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14421/biomedich.2026.151.91-95

Abstract

Breast cancer is a disease that has long been a source of concern for the public due to its high mortality rate. Excessive exposure to free radicals has been identified as a potential carcinogen, thus necessitating the utilization of antioxidants to counteract the damaging effects of these molecules. Gandaria (Bouea macrophylla Griff.) is a plant that is commonly found in Java, Sumatra, Maluku, and Kalimantan. B. macrophylla is known to have strong antioxidant activity, which is correlated with anticancer activity. A part of B. macrophylla that has not been extensively researched is its stem bark. The objective of this study was to analyze the potential of the ethyl acetate fraction of B. macrophylla stem bark as an anticancer agent using in silico method. The ethyl acetate fraction of B. macrophylla stem bark was characterized by LC-MS, which revealed four major compounds: 4-hydroxy-3-(3-oxo-1-phenylbutyl)-chromen-2-one, 1-(2,5-dihydroxyphenyl)-propan-1-one, 3-ethoxy-4-hydroxybenzaldehyde, and 2-nitrobenzoic acid. Molecular docking was performed between the compounds against the HER2 protein with PDB ID 3RCD. The four compounds demonstrated binding energy values of -8.29 kcal/mol, -5.04 kcal/mol, -4.66 kcal/mol, and -4.28 kcal/mol, respectively.
The Effect of Methanol Concentrations Against Phenolic Total Content and Antioxidant of Balakacida Leaves (Chromolaena odorata) Sriwijayanti Sriwijayanti; Ahmad Firdaus; Boima Situmeang; Holisha Widiyanto; Dian Susvira
Biology, Medicine, & Natural Product Chemistry Vol 15, No 1 (2026)
Publisher : Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14421/biomedich.2026.151.239-244

Abstract

The balakacida plant with the Latin name Chromolaena odorata is a plant that lives in a tropical climate. The balakacida plant is a plant of the Asteraceae Family. Phytochemical tests on balakacida leaves showed the presence of secondary metabolites of the tannin, phenol, flavonoid, saponin and steroid groups. This study aims to extract balakacida leaves and test the total phenolic and antioxidant content. Sample extraction was carried out by the maceration method using methanol solvent. Testing of total phenolic content using the Folin Ciocalteu method, while testing of antioxidant content using the DPPH method using a UV-Vis spectrophotometer. The results showed that the concentration of methanol solvent significantly affected the acquisition of total phenolics and antioxidants. The highest total phenolic content was obtained at a methanol extract concentration of 80% of 145.64 mg GAE/g. For antioxidant content, a methanol extract concentration of 60% showed the highest activity with an average DPPH % inhibition of 59.77%. It can be concluded that a methanol extract concentration of 60% is the optimal concentration to produce balakacida leaf extract with the best antioxidant activity, although not with the highest total phenolic content.
Co-Authors Ahmad Firdaus Boima Ramses Situmeang Dian Susvira Holisha Widiyanto Junia Salsha Primawati Siti Safuroh Yuke Agustin