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All Journal African Journal of Biochemistry and Molecular Biology Research African Journal of Clinical Medicine and Pharmacy Research
Isaac Eleojo Shaibu
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Biochemistry, Genetics & Molecular Biology Immunology & microbiology Medicine & Pharmacology Nursing Public Health

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Antihyperlipidemic and Haematological Effect of Triherbal Formulation on Triton1339-Induced Hyperlipidemic Rats Isaac John Umaru; Yakubu Ojochenemi Ejeh; Isaac Eleojo Shaibu; Adeyanju Kate Yemisi; Akoh Miracle Talent; Lawal Favour Enyojo
African Journal of Biochemistry and Molecular Biology Research Vol 2 No 2 (2025): African Journal of Biochemistry and Molecular Biology Research
Publisher : Darul Yasin Al Sys

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58578/ajbmbr.v2i2.5325

Abstract

Hyperlipidemia is one of the principal factors underlying the risk for cardiovascular disease. Confirmatory evidence from animal, clinical, and epidemiological studies has clearly established the positive correlation. Allopathic antihyperlipidemic drugs are available but the side effects and contraindications. However, this study was designed to determine the haematological and antihyperlipidemic effect of ethanol leaf ex­tract of triherbal formulation (Mucuna pruriens, Phyllantus amarus, Securidaca longipeduculata) in wistar rat as a cheaper and readily available alternative. 46rats were grouped into normal, diseased, standard drug controls and test groups with seven rats each. quantitative phytochemical, haematological and antihyperlipidemic analysis were carried out according to standard methods. Results revealed presence of saponin, alkaloids, tannin, flavonoids, cardiac glycosides, phenolic with Total phenol exhibiting the highest values haematological results showed improving activities of the formulation on the erythrocytes, heamoglobins, lymphocytes and neutrophiles, this confers good effect on heamatological and immonological parameters especially at higher dose. In antihyperlipidemic activities, triherbal formulation significantly (p≤0.05) decrease the level of TC, TAG, LDL and improve upon HDL in both serum and liver homogenate effects thought to be via inhibition of cholesterol biosynthesis, absorption modification of lypogenic and lipolitic enzymes. Conclusively, the studies indicated triherbal formulation contain bioactive compounds with diverse biological activities such as immunomodulatory, inflammatory, heamatological and lipid profile regulating activities.
Phytochemical and Mineral Composition of Triherbal Formulation Isaac John Umaru; Yakubu Ojochenemi Ejeh; Isaac Eleojo Shaibu; Agbo Christiana Onyindia; Prosper Uneju Peter; Victor Duniya Sheneni
African Journal of Clinical Medicine and Pharmacy Research Vol 2 No 2 (2025): African Journal of Clinical Medicine and Pharmacy Research
Publisher : Darul Yasin Al Sys

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58578/ajcmpr.v2i2.5339

Abstract

Herbal combinations are widely used for the treatment of various diseases in the developing countries. Their ability in boosting the immune system is a function of Mineral constituents present. Currently available drugs have been associated with number of side effects. Herbal Combinations have often been used in traditional medicine systems like Ayurveda, unani, African, Chinese Medicine, and Western herbalism. Combination of herbs is superior with increased therapeutic efficacy to individual herb. Triherbal combinations consisting of (Mucuna pruriens, Phyllantus amarus and Securidaca longipedunculata) 1:1:1 ratio W/W. The study was aimed at investigating the phytochemical profile, in-vivo antioxidant activities, The quantitative Phytochemical result revealed present of Alkaloids, Flavonoids, Terpenoids, Saponins and glycosides with Total phenol having the highest values (111.67±0.23mg/GAE/g) followed by (92.50±0.14mg/GAE/g). Chemical profiling analysis showed two prominent compounds chlorogenic acid (78.2 %) and Caffeic acid (21.8%.).The results of Mineral compositions clearly indicated that triherbal fromulation is a rich sources of minerals indicating the presence of the following: Sodium(Na), Potassium(k), Magnesium(Mg), Calcium(Ca), Iron(Fe), Phosphporus (P), and Zinc(Zn) with Magnesium having the highest value of (830.5±0.0) and the least value zinc (9.8±0.14). Conclusively, These findings indicate that these triherbal formulations contain the essential minerals and bioactive compounds consequently exhibiting diverse biochemical activities, through multiple mechanism that could probably boost the immune system, making this formulation a potential therapeutic interventions for preventing liver damage and maintaining overall health.
Co-Authors Adeyanju Kate Yemisi Agbo Christiana Onyindia Akoh Miracle Talent Isaac John Umaru Lawal Favour Enyojo Prosper Uneju Peter Victor Duniya Sheneni Yakubu Ojochenemi Ejeh