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All Journal Proceeding Mulawarman International Conference on Tropical Public Health
Zelin Patarena Dawi Pramesti
University of Brawijaya
Public Health

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THE EFFECT OF CAMELLIA SINENSIS EXTRACT ON HORMONES AND BODY WEIGHT IN ANIMAL MODELS WITH POLYCYSTIC OVARY SYNDROME (PCOS): A SYSTEMATIC REVIEW AND META-ANALYSIS Safira Mauliyatul Chusna; Zelin Patarena Dawi Pramesti; Faris Regi Riswana; Eri Kurniasari; Noza Loviana
Mulawarman International Conference on Tropical Public Health Vol. 2 No. 2 (2025): The 4th MICTOPH
Publisher : Faculty of Public Health Mulawarman University, Indonesia

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Abstract

Background: Polycystic Ovary Syndrome (PCOS) is the most common polygenic endocrine disorder in women of reproductive age. PCOS is characterized by symptoms of excess androgen hormones, ovulation disorders, and obesity. The polyphenol content in Camellia sinensis extract has been reported to be beneficial in lowering testosterone levels and stabilizing luteinizing hormone production, thereby improving the ovulation process in PCOS patients. Objective: Identify studies that use clinical trials and studies that evaluate Camellia sinensis extract in animal models of PCOS Method:  A comprehensive search was conducted on five databases, including SCOPUS, Science Direct, PubMed, ProQuest, and EBSCO met inclusion criteria. Risk of bias was assessed using SYRCLE’s. Data were analyzed using RevMan 5.4 software. Result: Three studies were included in the meta-analysis, which involved 74 female rats. Compared to the untreated PCOS rat group, managing of Camellia sinensis polyphenols to PCOS rats had a significant effect in reducing testosterone levels (MD = -7.17, 95% CI: -9.96 to -4.39, P < 0.00001, I² = 59%), luteinizing hormone (LH) levels (MD = -4.57, 95% CI: -4.67 to -4.46, P < 0.00001, I² = 15%), and body weight (MD = -40.31, 95% CI: -50.62 to -30.00, P < 0.00001, I² = 0%) indicating high consistency of treatment effects across all included studies. Conclusion: Camellia sinensis polyphenols significantly reduced testosterone, LH, and body weight levels in PCOS mouse models, demonstrating their potential as an effective alternative therapy for polycystic ovary syndrome management.
Co-Authors Eri Kurniasari Faris Regi Riswana Noza Loviana Safira Mauliyatul Chusna