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All Journal Proceeding Mulawarman International Conference on Tropical Public Health
Faris Regi Riswana
University of Brawijaya
Public Health

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Accuracy of Visual Inspection with Acetic Acid for Cervical Lesions: A Systematic Review and Meta-Analysis Faris Regi Riswana; Faris Rega Riswana; Krisjentha Iffah Agustasari; Nabila Khairunisa Azzahra
Mulawarman International Conference on Tropical Public Health Vol. 2 No. 2 (2025): The 4th MICTOPH
Publisher : Faculty of Public Health Mulawarman University, Indonesia

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Background: Cervical cancer is the most common cancer and a main cause of death among women in low- and middle-income country. A simple screening method using Visual Inspection with Acetic Acid (VIA) has been recommended. However, the diagnostic accuracy of this test varies across populations and clinical contexts. Objective: To evaluate the diagnostic accuracy of VIA compared with the gold standard (histopathology) for detecting precancerous lesions in the cervix. Research Methods: A systematic search was conducted in PubMed, Scopus, and ScienceDirect from 2015 to 2025 following the PRISMA guidelines. A total of 764 studies were identified and only 15 studies were included, with a total sample of 3,237. The risk of bias was assessed using the QUADAS-2. Studies reporting diagnostic outcomes (TP, FP, TN, FN) were included in this review. The data were analysed using a bivariate random-effects model with HSROC curve. Results: The overall analysis showed a pooled sensitivity of 68% (95% CI: 55–80%) and a specificity of 79% (95% CI: 66–88%), indicating moderate diagnostic accuracy across studies. The HSROC curve was positioned toward the upper-left region, reflecting higher specificity and improved model stability. Subgroup analysis revealed that VIA in HIV-negative women demonstrated the best diagnostic performance sensitivity 78%, specificity 85%. When VIA was used as a primary test, it exhibited the most balanced accuracy sensitivity 75%, specificity 80% compared with VIA as a triage test. Conclusion: VIA test demonstrates moderate diagnostic accuracy for detecting cervical precancerous lesions, the best performing in HIV-negative populations, and when used as a primary test.
THE EFFECT OF CAMELLIA SINENSIS EXTRACT ON HORMONES AND BODY WEIGHT IN ANIMAL MODELS WITH POLYCYSTIC OVARY SYNDROME (PCOS): A SYSTEMATIC REVIEW AND META-ANALYSIS Safira Mauliyatul Chusna; Zelin Patarena Dawi Pramesti; Faris Regi Riswana; Eri Kurniasari; Noza Loviana
Mulawarman International Conference on Tropical Public Health Vol. 2 No. 2 (2025): The 4th MICTOPH
Publisher : Faculty of Public Health Mulawarman University, Indonesia

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Background: Polycystic Ovary Syndrome (PCOS) is the most common polygenic endocrine disorder in women of reproductive age. PCOS is characterized by symptoms of excess androgen hormones, ovulation disorders, and obesity. The polyphenol content in Camellia sinensis extract has been reported to be beneficial in lowering testosterone levels and stabilizing luteinizing hormone production, thereby improving the ovulation process in PCOS patients. Objective: Identify studies that use clinical trials and studies that evaluate Camellia sinensis extract in animal models of PCOS Method:  A comprehensive search was conducted on five databases, including SCOPUS, Science Direct, PubMed, ProQuest, and EBSCO met inclusion criteria. Risk of bias was assessed using SYRCLE’s. Data were analyzed using RevMan 5.4 software. Result: Three studies were included in the meta-analysis, which involved 74 female rats. Compared to the untreated PCOS rat group, managing of Camellia sinensis polyphenols to PCOS rats had a significant effect in reducing testosterone levels (MD = -7.17, 95% CI: -9.96 to -4.39, P < 0.00001, I² = 59%), luteinizing hormone (LH) levels (MD = -4.57, 95% CI: -4.67 to -4.46, P < 0.00001, I² = 15%), and body weight (MD = -40.31, 95% CI: -50.62 to -30.00, P < 0.00001, I² = 0%) indicating high consistency of treatment effects across all included studies. Conclusion: Camellia sinensis polyphenols significantly reduced testosterone, LH, and body weight levels in PCOS mouse models, demonstrating their potential as an effective alternative therapy for polycystic ovary syndrome management.
Co-Authors Eri Kurniasari Faris Rega Riswana Krisjentha Iffah Agustasari Nabila Khairunisa Azzahra Noza Loviana Safira Mauliyatul Chusna Zelin Patarena Dawi Pramesti