I Gusti Ayu Rai Widowati
Bali International University

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Effectiveness Probiotics as Anti-Aging for Facial Skin: A Systematic Review Putu Adinda Novyta Arsha Putri; Ida Ayu Manik Partha Sutema; I Putu Gede Adi Purwa Hita; I Gusti Ayu Rai Widowati
Journal of Pharmascience Vol. 13 No. 1 (2026): Jurnal Pharmascience
Publisher : Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jps.v13i1.22558

Abstract

Premature skin aging is increasingly prevalent among individuals in their mid-20s to 30s, influenced by genetic, lifestyle, and environmental factors. Probiotics have emerged as a promising natural intervention to address this issue. This systematic review aimed to evaluate the effectiveness of oral and topical probiotics in preventing and managing signs of premature skin aging. A systematic search of PubMed and Scopus was conducted for Randomized Controlled Trials (RCTs) published between 2020 and 2025, using PICO-based inclusion and exclusion criteria. Methodological quality was assessed with the JBI checklist. Of 202 articles screened, eight RCTs were included. Results showed that oral probiotics improved skin quality by enhancing collagen production (24%), hydration (18%), and antioxidant activity, while topical probiotics reduced wrinkles (22%) and increased skin density (15%). In conclusion, oral and topical probiotics represent effective dual strategies for combating premature skin aging, though further studies are needed to optimize strain-specific formulations.
The Community Service on Antibiotics Use at Banjar Pinda Gianyar Manik Partha Sutema Ida Ayu; Ni Putu Aryati Suryaningsih; I Gusti Ayu Rai Widowati; Ni Made Maharianingsih
Journal of Health Community Service Vol. 5 No. 1 (2025): Journal of Health Community Service: 2025 January
Publisher : UNUSA Press

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Abstract

Self-medication with antibiotics elevates the threat of resistance, which increases morbidity and mortality. Antibiotic resistance (AMR) in humans must be avoided and reduced. The objective of this community service was to educate housewives about the crucial role of restricting self-medication with antibiotics in the fight against AMR. On March 14, 2023, the Department of Pharmacy at Bali International University executed this community service. The health education intervention was carried out in Banjar Pinda, Gianyar Regency. At least 79 housewives were attending. The event went well, and participants interacted with the presenters enthusiastically. It is implied that community service in Banjar Pinda-Gianyar imparts knowledge about health and the importance of AMR awareness. This program should be expanded to involve other community groups such as craftsmen, the elderly, and young people.