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All Journal Journal of Research in Pharmacy and Pharmaceutical Sciences Journal of Pharmascience
Eldiza Puji Rahmi
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Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Other

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Acute Oral Toxicity of Methanolic Extracts from the Fruit and Leaf of Parijoto (Medinilla speciosa Blume) in Mice Annisa Farida Muti; Refian Ariesta Eka Maulana; Dhigna Luthfiyani Citra Pradana; Eldiza Puji Rahmi
Journal of Pharmascience Vol. 13 No. 1 (2026): Jurnal Pharmascience
Publisher : Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jps.v13i1.24762

Abstract

Medinilla speciosa Blume, or parijoto, contains flavonoids, saponins, alkaloids, and tannins with pharmacological potential. However, information regarding its safety profile, particularly acute toxicity data, is still very limited, so research is needed to evaluate its safety level. This study aims to evaluate the acute oral toxicity of M. speciosa leaf and fruit extracts in ddY mice. This study used a true experimental design. M. speciosa leaf and fruit extracts were obtained by ultrasonic-assisted extraction with methanol as a solvent. The acute oral toxicity test was conducted with a fixed-dose method at a single dose of 2000 mg/kgBW. Parameters observed for 14 days included mortality, clinical symptoms of toxicity, body weight changes, relative organ weights, and histopathological analysis of the liver and kidneys. The findings indicated an absence of fatalities across all treatment groups. The LD50 values for both extracts were determined to exceed 2000 mg/kgBW, categorising the fruit and leaf extracts as mildly toxic (category 5). Mild toxic symptoms were only observed in the treatment group receiving the fruit extract. Histopathological analysis of the liver and kidneys revealed mild cellular changes that were not statistically significant. Therefore, a single oral administration of M. speciosa fruit and leaf extracts at doses up to 2000 mg/kgBW is relatively safe.
COMPARATIVE TEST OF EFFECTIVENESS OF ALCOHOL MIXTURE BASE HAND SANITIZER WITH CHLORHEXIDINE MIXTURE BASE ON ESCHERICHIA COLI AND SHIGELLA SONNEI BACTERIA eldiza puji rahmi; Annisa Farida Muti; Dhinga Luthfiyani Pradana; Mikhael Valentino; Salwa Nisrina Cahyadi; Putri Andini; Muhamad Ferdian; Tiyon Widjaja; Brooklyn Razan Fachrudin; Annisa Hasna Nabila; Salsabilla Puteri Wandira; Sirly Marliah Saputri; Khayla Shifa Azzahra; Alfina Aprilia Kusumaningrum; Cut Laila Nur Shabrina; Rabbiah Putri Nurjannah
Journal of Research in Pharmacy and Pharmaceutical Sciences Vol 2 No 1 (2023): Vol.2 No.1 JUNE (2023)
Publisher : Pharmacy Program, Faculty of Medicine, UPN Veteran Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33533/jrpps.v2i1.7013

Abstract

ABSTRACT Hand sanitizer is a hand cleanser which is easy and practical in use. Using hand sanitizer can be an alternative for washing hands if in condition without water and soap. Hand sanitizer is used to clean pathogens on hands. The ability to kill pathogens in hand sanitizers is due to the active substance content in them. In this research, the effectiveness of 2 hand sanitizers on the market was tested. The test aims to see the effect of the active substances in each preparation on the effectiveness of killing pathogens. Testing was carried out using the Kirby Bauer method and on 2 bacterial media, namely Escherichia coli and Shigella sonnei. Hand sanitizer 1 has a composition consisting of 70% ethyl alcohol and 0.5% chlorhexidine. Hand sanitizer 2 has a composition consisting of 55% ethyl alcohol and 18% isopropyl alcohol with a total of 73% alcohol. Based on observations, it was found that hand sanitizer 1 was more effective than hand sanitizer 2. The chlorhexidine content in hand sanitizer 1 increased its effectiveness in killing pathogens.
THE RELATIONSHIP OF COMPLIANCE WITH MEDICATION ON BLOOD PRESSURE STABILITY IN HYPERTENSION PATIENTS AT CINERE DISTRICT HEALTH CENTER 2023 Salsabila Sumantri; eldiza puji rahmi; Via Rifkia; Dhinga Luthfiyani Pradana
Journal of Research in Pharmacy and Pharmaceutical Sciences Vol 2 No 2 (2023): Vol.2 No.2 DECEMBER (2023)
Publisher : Pharmacy Program, Faculty of Medicine, UPN Veteran Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33533/jrpps.v2i2.7416

Abstract

Several reasons for hypertension sufferers who do not comply with taking medication will slow down healing time and worsen the patient's condition and can even cause death. This study aims to determine the characteristics of hypertensive patients at the Cinere Community Health Center, the results of antihypertensive therapy at the Cinere Community Health Center and to determine the relationship between adherence to medication use and the success of therapy at the Cinere Community Health Center. This research uses a correlational analytical research design. Based on the discussion above, it can be concluded that the characteristics of hypertensive patients at the Cinere Community Health Center are the majority aged 45-65 years, female with the highest education level being elementary school and having suffered for > 1 year. The majority of medication adherence among hypertensive patients at the Cinere Community Health Center is still relatively low. The success of therapy in hypertensive patients at the Cinere Community Health Center resulted in a reduction in blood pressure of 31 people and in patients who did not reduce blood pressure there were 71 people. There is a relationship between adherence to taking medication and blood pressure stability in hypertensive patients at the Cinere Community Health Center
Co-Authors Alfina Aprilia Kusumaningrum Annisa Farida Muti Annisa Hasna Nabila Brooklyn Razan Fachrudin Cut Laila Nur Shabrina Dhinga Luthfiyani Pradana Khayla Shifa Azzahra Mikhael Valentino Muhamad Ferdian Putri Andini Rabbiah Putri Nurjannah Refian Ariesta Eka Maulana Salsabila Sumantri Salsabilla Puteri Wandira Salwa Nisrina Cahyadi Sirly Marliah Saputri Tiyon Widjaja Via Rifkia