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All Journal Fullerene Journal of Chemistry
Agnia Purnama
Universitas Syiah Kuala
Chemistry

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Fractionation, Purification, and Toxicity of Methanolic Cacao Pod Husk Extract (Theobroma cacao L.) Agnia Purnama; Mustanir Yahya; Binawati Ginting; Nurdin Saidi; Muhammad Ridha Afifi; Ruhul Maghfirah; Mutia Farida; Ikhsan Ikhsan
Jurnal Kimia Fullerene Vol 11 No 2: Fullerene Journal Of Chemistry
Publisher : Fakultas Matematika dan Ilmu Pengetahuan Alam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37033/fjc.v11i2.772

Abstract

Cacao (Theobroma cacao, L.) is a plantation product that has good prospects, but its processing produces a by-product in the form of cacao pod husks that have not been optimally utilized. This study aims to analyze the toxicity of methanol extracts, fractions, and subfractions of cacao pod husks using the Brine shrimp lethality test (BSLT) assay, and to purify active compounds using gravity column chromatography and thin-layer chromatography (TLC). The fractionation process of the methanol extract produced 5 fractions and 4 subfractions. The results of the toxicity analysis showed that the TCM 2 fraction and the TCM 2.1 subfraction had the highest toxicity, with IC₅₀ values of 38.68 ppm and 28.85 ppm, respectively. Further purification process produced a single isolate identified as a terpenoid compound. The results of this study indicate that cacao pod husks have the potential to serve as a natural source of toxicity and can be developed for use in the pharmaceutical field.
Co-Authors Binawati Ginting Ikhsan Ikhsan Muhammad Ridha Afifi Mustanir Yahya Mutia Farida Nurdin Saidi Ruhul Maghfirah