Article Per Year (5 Year)
p-Index From 2021 - 2026
0.23
P-Index
This Author published in this journals
All Journal Media Farmasi : Jurnal Ilmu Farmasi (Journal Of Pharmaceutical Science)
Sri Wahdaningsih
Faculty of Medicine, Universitas Tanjungpura, Pontianak, Indonesia
Chemistry Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology

Published : 1 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 1 Documents
Search

 1 
Hylocereus polyrhizus Fruit Peel Extract as a Hepatoprotective Agent: Histopathological Profile Study in Rattus norvegicus Muhammad Rafly Agustriangga; Sri Wahdaningsih; Shoma Rizkifani
Media Farmasi: Jurnal Ilmu Farmasi Vol. 23 No. 1 (2026): March 2026
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/mf.v23i1.29928

Abstract

Paracetamol overdose is a major cause of acute liver failure, necessitating the search for effective natural antidotes. The peel of Red Dragon Fruit (Hylocereus polyrhizus) is an abundant agro-waste product rich in betacyanins and flavonoids, yet its potential as a sustainable hepatoprotective agent remains underexplored. This study aimed to valorize this waste product by evaluating the hepatoprotective activity of H. polyrhizus peel extract against paracetamol-induced liver injury in Wistar rats. Twenty-five male Wistar rats were divided into five groups: Negative Control, Positive Control (Paracetamol-induced), and three treatment groups pretreated with the extract (100, 200, and 300 mg/kg BW) for 7 days. Liver injury was assessed quantitatively based on necrosis, ballooning degeneration, and steatosis scores. The Positive Control group exhibited severe hepatocellular damage (p<0.05). However, pretreatment with the extract significantly attenuated this damage in a dose-dependent manner. The dose of 200 mg/kg BW demonstrated superior efficacy, restoring hepatic architecture to a state statistically comparable to the healthy control (p>0.05). The study confirms that H. polyrhizus peel extract effectively mitigates paracetamol toxicity, with 200 mg/kg identified as the optimal dose. This research contributes to the pharmaceutical field by providing scientific evidence for repurposing fruit peel waste as a potent, cost-effective, and eco-friendly source of hepatoprotective compounds.
Co-Authors Muhammad Rafly Agustriangga Shoma Rizkifani