Article Per Year (5 Year)
p-Index From 2021 - 2026
0.408
P-Index
This Author published in this journals
All Journal MEDULA Jurnal Ilmiah Fakultas Kedokteran Universitas Halu Oleo
Nuralifah
Halu Oleo University
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

Published : 2 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 2 Documents
Search

 1 
Ethanol Extract Activity of Teak Leaves (Tectona grandis L) Against Histopotological Appearance of Pancreatic Organs in Rats (Rattus norvegicus) Model Type II DM Nuralifah; Parawansah; Ruslin; Rachma Malina; Emma Haerunnita
MEDULA: Jurnal Ilmiah Fakultas Kedokteran Universitas Halu Oleo Vol. 10 No. 2 (2023): April
Publisher : MEDULA: Jurnal Ilmiah Fakultas Kedokteran Universitas Halu Oleo

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Background: Diabetes mellitus is a disease characterized by increased blood glucose levels and changes in the histopathological structure of the islets of Langerhans of the pancreas. One of the plants used empirically as an antidiabetic is the teak plant (Tectona grandis Linn). The content compounds that are thought to act as antidiabetics are flavonoids. Purpose: The purposes of this study is to determine the activity of the ethanol extract of Tectona grandis L leaves which has antihyperglycemic activity as seen from the histopathology of the pancreas of white rats (Rattus norvegicus). Methods: Modeling diabetes mellitus in test animals was carried out by inducing 40 mg/kg BW streptozotocin intraperitoneally. There were 6 treatment groups, namely the normal control group, the positive control group, the negative control group, and the teak leaf ethanol extract group at doses of 100, 200, and 300 mg/kg. Results: The ethanol extract of Tectona grandis leaves has repair activity for regenerating endocrine cells in the islets of Langerhans with an average number of endocrine cells in the normal control group of 483 cells, positive control group 474 cells, negative control 318 cells, dose 100 mg/kg body weight 450 cells, a dose of 200 mg/KBB 462 cells and a dose of 300 mg/KBB 469 cells and it can regenerate endocrine cells. Conclusion: the ethanol extract of Tectona grandis L leaves at a dose of 300 mg/kg BW has activity in repairing endocrine cells with cell morphology almost resembling normal cells.
The Impact of the Ethyl Acetate Fraction of Bitter Melon Fruit (Momordica charantia l.) on Insulin Hormone Levels of Diabetic Rats (Rattus norvegicus) Using the Enzyme-Linked Immunosorbent Assay Method Parawansah; Tien; Amiruddin Eso; Muhammad Junaid Azis; Nuralifah
MEDULA: Jurnal Ilmiah Fakultas Kedokteran Universitas Halu Oleo Vol. 10 No. 3 (2023): Suplemen
Publisher : MEDULA: Jurnal Ilmiah Fakultas Kedokteran Universitas Halu Oleo

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Background: The World Health Organization (WHO) has forecast a rise in the prevalence of diabetes mellitus from 2.8% in 2000 to 4.4% in 2030. Numerous investigations have been undertaken to identify alternate avenues for antidiabetic treatment. Momordica charantia, sometimes referred to as bitter melon, is recognized for its possession of mimic insulin components. The ethanol extracts derived from Momordica charantia have been found to exhibit favorable outcomes in the reduction of blood glucose levels and the stimulation of pancreatic beta cells for the secretion of insulin hormone. Purpose: The purpose of this research is to investigate the impact of bitter melon extract on insulin levels in rats induced with streptozotosin. Method: The present study employed various methodologies to investigate the research question. The present investigation comprised three distinct sets of tests, specifically streptozotosin-induced rats, streptozotosin-induced rats administered with an ethyl acetate fraction of Momordica charantia extract, and non-induced streptozotosin rats. The measurement of insulin levels is conducted using the enzyme-linked immunosorbent assay (ELISA) technique. If the p-value was more than 0.05, an unpaired T-test was employed for data analysis. Result: The research findings indicate that there is no statistically significant distinction in the insulin levels between streptozotosin-induced rats and streptozotosin-induced rats administered with the ethyl acetate fraction of the Momordica charantia extract group (p = 0.081). The insulin levels of streptozotosin-induced rats administered with an ethyl acetate fraction of Momordica charantia extract were found to be statistically similar to those of non-induced streptozotosin rats (p = 0.505). Conclusion: There is no discernible distinction in the insulin levels among streptozotosin-induced rats, streptozotosin-induced rats administered with an ethyl acetate fraction of Momordica charantia extract, and non-induced streptozotosin rats.
Co-Authors Amiruddin Eso Emma Haerunnita Muhammad Junaid Azis Parawansah Rachma Malina Ruslin Tien