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All Journal MEDULA Jurnal Ilmiah Fakultas Kedokteran Universitas Halu Oleo
Cahyono Kaelan
Hasanuddin University
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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Correlation between the Fazekas Scale for the Degree of Leukoaraiosis and the Score on the Mini Mental State Examination (MMSE) for Cognitive Disorders Nurcholish Akbar Monayo; Junus A.B. Baan; Rafikah Rauf; Andi Alfian Zainuddin; Cahyono Kaelan
MEDULA: Jurnal Ilmiah Fakultas Kedokteran Universitas Halu Oleo Vol. 10 No. 2 (2023): April
Publisher : MEDULA: Jurnal Ilmiah Fakultas Kedokteran Universitas Halu Oleo

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Background: Leukoaraiosis is part of the aging process and an indicator of brain damage in the elderly, which is characterized by cognitive dysfunction. However, the correlation between cognitive impairment and patients with leukoaraiosis is still poorly understood. Purpose: To assess the correlation between the degree of leukoaraiosis and cognitive impairment. Methods: The research was conducted at RSUP. Dr. Wahidin Sudirohusodo, Makassar in May 2022 until the sample was sufficient, using a cross-sectional research design. The study included all patients who were older than 40, who received a magnetic resonance imaging (MRI) test, and who fulfilled the inclusion and exclusion criteria. The Ethics Commission gave its approval to this study. The Fazekas scale was used to measure the severity of leukoaraiosis, and the MMSE score was used to measure cognitive impairment. The application SPSS version 26.0 was used to analyze the data. Univariate tests was used to minimum and maximum values, standard deviation, frequency, percentage, or mean. Bivariate test was used to Spearman's correlation test. bivariate test using Spearman's correlation test. Results: This study consisted of 39 people; 10 people (25.6%) had mild cognitive impairment and 29 people (74.4%) did not have cognitive impairment, 6 people (15.4%) had leukoaraiosis degree, 0, 18 people (46.2%) had leukoaraiosis grade 1 , 10 people (25.6%) had a degree of leukoaraiosis 2, and 5 people (12.8%) had a degree of leukoaraiosis 3. There was a negative correlation between the degree of leukoaraiosis and cognitive impairment (p = 0.008). Conclusion: The degree of leukoaraiosis using the Fazekas scale can be used for early diagnosis of cognitive disorders, so that it can immediately prevent the severity of cognitive disorders.
Neuroprotective Effect of Brain-Derived Neurotrophic Factor (BDNF) on Cerebral Infarct Volume and Clinical Severity of Acute Ischemic Stroke Satrio Wicaksono; Andi Kurnia Bintang; Muhammad Akbar; Muhammad Yunus Amran; Cahyono Kaelan; Isra Wahid
MEDULA: Jurnal Ilmiah Fakultas Kedokteran Universitas Halu Oleo Vol. 12 No. 1 (2024): Desember
Publisher : MEDULA: Jurnal Ilmiah Fakultas Kedokteran Universitas Halu Oleo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46496/medula.v12i1.45

Abstract

ABSTRACT Background: Brain-Derived Neurotrophic Factor (BDNF) plays a crucial role in protecting nerves following ischemic stroke. The neuroprotective effects of BDNF on cerebral infarct volume and clinical severity after ischemic stroke need to be further studied in-depth. Purpose(s): The purpose of this study is to understanding the relationship between BDNF levels, cerebral infarct volume, and the severity of clinical conditions in acute ischemic stroke patients. Methods: This study is an observational nalytical research with a cross-sectional design. A total of 30 individuals who meet the inclusion criteria were included as samples. Cerebral infarct volume was measured using non-contrast head CT scans with the Broderick formulation, and clinical severity was assessed using the National Institutes of Health Stroke Scale (NIHSS). The collected data were then analyzed using statistical tests. Results: There is a significant relationship between serum BDNF levels and cerebral infarct volume with a p-value of 0.004 and a correlation coefficient (r) of -0.509. Similarly, a significant relationship exists between serum BDNF levels and NIHSS with a p-value of 0.042 and a correlation coefficient (r) of -0.374. Conclusion: There is a negative correlation between serum BDNF levels and cerebral infarct volume in acute ischemic stroke patients, as well as a negative correlation between serum BDNF levels and clinical severity in acute ischemic stroke patients. Keywords: BDNF; Infarct Cerebri Volume; NIHSS
Co-Authors Andi Alfian Zainuddin Andi Kurnia Bintang Isra Wahid Junus A.B. Baan Muhammad Akbar Muhammad Yunus Amran Nurcholish Akbar Monayo Rafikah Rauf Satrio Wicaksono